Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press27810.36691/RJA278ArticlesСтатьиReview ArticleDIAGNOSIS OF DELAYED DRUG ALLERGIC REACTIONSДИАГНОСТИКА ЛЕКАРСТВЕННОЙ АЛЛЕРГИИ, ПРОТЕКАЮЩЕЙ ПО ЗАМЕДЛЕННОМУ ТИПУRomanovaT SРомановаТатьяна Сергеевна

врач аллерголог-иммунолог, научный сотрудник отделения иммунопатологии.

tsromanova@mail.ruMyasnikovaT NМясниковаТатьяна Николаевна

старший научный сотрудник отделения иммунопатологии, кандидат медицинских наук.

KhludovaL VХлудоваЛюдмила Геннадьевна

аспирант отделения иммунопатологии

SmirnovV GСмирновВалерий Валерьевич

заведующий лабораторией № 73, кандидат фармакологических наук.

LatyshevaT VЛатышеваТатьяна Васильевна

руководитель отделений иммунопатологии и интенсивной терапии, анестезиолог-реаниматолог, Заслуженный врач России, доктор медицинских наук, профессор

NRC Institute of Immunology FMBA of RussiaФГБУ «ГНЦ Институт иммунологии» ФМБА России14122017146NO6 (2017)№6 (2017)72010032020Copyright ©; 2017, Pharmarus Print MediaCopyright ©; 2017, Фармарус Принт Медиа2017Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/278

Mechanisms of delayed druginduced allergies (DDIA), individual features of the immune response to the drug, influence of various cofactors (concomitant pathology, viral infection, insolation, etc.) create difficulties in diagnostics of drug allergy (DA). Identification and elimination of a causative drug allows to prevent the development of severe allergic reactions. Verification of DA diagnosis during the survey allows to avoid the unreasonable lifelong ban on application of certain drug, which often leads to decreasing of treatment efficiency and increasing its cost. In vitro diagnostic tests are safe, but laborious and expensive. This article will provide the review of literature, reflecting a modern view on the diagnosis of DDIA.

Сложность механизмов развития лекарственной аллергии замедленного типа (ЛАЗТ), индивидуальные особенности иммунного ответа на лекарственный препарат (ЛП), влияние различных кофакторов (сопутствующая патология, вирусная инфекция, инсоляция и т. п.) создают трудности при разработке диагностических тестов. Необходимо не только правильно поставить диагноз, но и выявить причиннозначимый ЛП, исключение которого позволяет профилактировать развитие повторных аллергических реакций, которые, как правило, протекают тяжелее. Исключение диагноза лекарственной аллергии (ЛА) в ходе обследования позволяет избежать необоснованных пожизненных запретов на применение тех или иных ЛП, которые зачастую приводят к снижению эффективности лечения и увеличению его стоимости. Методы диагностики in vitro безопасные, но трудоемкие и дорогостоящие. В обзоре отражен современный взгляд на диагностику лекарственной аллергии, протекающей по замедленному типу.

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