Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press19010.36691/RJA190ArticlesСтатьиResearch ArticleMicrobiome of human skin - its immunohomeostatic role and the role in pathogenesis of skin diseasesМикробиом человеческой кожи - иммуногомеостатическая роль и роль в патогенезе кожных болезнейPetruninD DПетрунинДмитрий Дмитриевич

кандидат медицинских наук, менеджер по научно-медицинским вопросам, врач-дерматовенеролог

prof.preobrazhenskii@gmail.comLEO Pharmaceutical Products LLCООО «ЛЕО Фармасьютикал Продактс»15022018151VOL 15, NO1 (2018)ТОМ 15, №1 (2018)638110032020Copyright ©; 2018, Pharmarus Print MediaCopyright ©; 2018, Фармарус Принт Медиа2018Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/190

In the last decade new methods of metagenomic analysis allowed to obtain important data regarding the microbiome of human skin. The problem of colonization and secondary infection by pathogenic microbes is of special importance for allergic dermatoses that require topical immunosuppressive therapy. One of treatment options in this case could be topical multicomponent drugs that allow successful treatment of infectious complications of inflammatory dermatoses. But there are still a lot of blanks regarding both fundamental questions regarding human skin microbiome and practice aspects of treatment of skin diseases where it plays a pathogenetic role. This literature review systematizes and structures the accumulated data regarding the composition and the role of human skin microbiome in normal conditions and in various skin diseases as well as summarizes clinical data of use of combinational topical glucocorticosteroid drugs. Furthermore, some algorithms concerning the choice and optimization of topical treatment of secondary infected dermatoses are outlined.

В последнее десятилетие благодаря новым методам метагеномного анализа получены важные сведения о микробиоме человеческой кожи. Продолжается изучение гомеостатической и патогенетической роли микроорганизмов, колонизирующих покровные ткани человека. Для аллергодерматозов, в лечении которых применяются наружные препараты с иммуносупрессивным эффектом, проблема колонизации и вторичного инфицирования патогенными микроорганизмами особенно значима. Одним из вариантов решения могут быть многокомпонентные препараты для наружного применения, которые позволяют успешно лечить инфекционные осложнения воспалительных дерматозов. Однако по сей день существует множество «белых пятен», касающихся как фундаментальных вопросов, связанных с микробиомом человеческой кожи, так и практических аспектов лечения кожных заболеваний, в патогенезе которых он играет роль. Данный обзор литературы систематизирует и структурирует накопленные данные о составе и роли микробиома кожи человека в норме и при различных кожных заболеваниях и обобщает сведения о клиническом применении комбинированных глюкокортикостероидных препаратов. Кроме того, приводятся некоторые алгоритмы по выбору и оптимизации наружной терапии вторично инфицированных дерматозов.

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