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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="letter" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">17134</article-id><article-id pub-id-type="doi">10.36691/RJA17134</article-id><article-id pub-id-type="edn">RETCRK</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Letters to the editor</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Письма в редакцию</subject></subj-group><subj-group subj-group-type="article-type"><subject>Correspondence</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The role and place of dexpanthenol preparations in the prevention and treatment of atopic dermatitis, eczema, and other dermatoses in children and adults: resolution of the Expert Council of Russia</article-title><trans-title-group xml:lang="ru"><trans-title>Роль и место препаратов декспантенола в профилактике и лечении атопического дерматита, экземы и других дерматозов у детей и взрослых: резолюция совета экспертов России</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3039-7769</contrib-id><contrib-id contrib-id-type="spin">6222-8684</contrib-id><name-alternatives><name xml:lang="en"><surname>Rakhmatulina</surname><given-names>Margarita R.</given-names></name><name xml:lang="ru"><surname>Рахматулина</surname><given-names>Маргарита Рафиковна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>rahmatulina@cnikvi.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6378-8582</contrib-id><contrib-id contrib-id-type="spin">9094-9688</contrib-id><name-alternatives><name xml:lang="en"><surname>Araviyskaya</surname><given-names>Elena R.</given-names></name><name xml:lang="ru"><surname>Аравийская</surname><given-names>Елена Роальдовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>arelenar@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4609-2591</contrib-id><contrib-id contrib-id-type="spin">9567-1894</contrib-id><name-alternatives><name xml:lang="en"><surname>Elisyutina</surname><given-names>Olga G.</given-names></name><name xml:lang="ru"><surname>Елисютина</surname><given-names>Ольга Гурьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>el-olga@yandex.ru</email><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5044-5265</contrib-id><contrib-id contrib-id-type="spin">1107-4372</contrib-id><name-alternatives><name xml:lang="en"><surname>Kruglova</surname><given-names>Larisa S.</given-names></name><name xml:lang="ru"><surname>Круглова</surname><given-names>Лариса Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>kruglovals@mail.ru</email><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9085-6229</contrib-id><contrib-id contrib-id-type="spin">3312-3150</contrib-id><name-alternatives><name xml:lang="en"><surname>Letyaeva</surname><given-names>Olga I.</given-names></name><name xml:lang="ru"><surname>Летяева</surname><given-names>Ольга Ивановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>olga-letyaeva@yandex.ru</email><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7571-5460</contrib-id><contrib-id contrib-id-type="spin">6289-0209</contrib-id><name-alternatives><name xml:lang="en"><surname>Novik</surname><given-names>Gennady A.</given-names></name><name xml:lang="ru"><surname>Новик</surname><given-names>Геннадий Айзикович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>ga_novik@mail.ru</email><xref ref-type="aff" rid="aff7"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8584-615X</contrib-id><contrib-id contrib-id-type="spin">5518-6453</contrib-id><name-alternatives><name xml:lang="en"><surname>Smirnova</surname><given-names>Irina O.</given-names></name><name xml:lang="ru"><surname>Смирнова</surname><given-names>Ирина Олеговна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>driosmirnova@yandex.ru</email><xref ref-type="aff" rid="aff8"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7610-6061</contrib-id><contrib-id contrib-id-type="spin">6807-7137</contrib-id><name-alternatives><name xml:lang="en"><surname>Sokolovskiy</surname><given-names>Evgeny V.</given-names></name><name xml:lang="ru"><surname>Соколовский</surname><given-names>Евгений Владиславович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>s40@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3261-6718</contrib-id><contrib-id contrib-id-type="spin">5476-8497</contrib-id><name-alternatives><name xml:lang="en"><surname>Tamrazova</surname><given-names>Olga B.</given-names></name><name xml:lang="ru"><surname>Тамразова</surname><given-names>Ольга Борисовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>anait_tamrazova@mail.ru</email><xref ref-type="aff" rid="aff9"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3358-5087</contrib-id><contrib-id contrib-id-type="spin">5012-7242</contrib-id><name-alternatives><name xml:lang="en"><surname>Fedenko</surname><given-names>Elena S.</given-names></name><name xml:lang="ru"><surname>Феденко</surname><given-names>Елена Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>efedks@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">State Research Center of Dermatovenereology and Cosmetology</institution></aff><aff><institution xml:lang="ru">Государственный научный центр дерматовенерологии и косметологии</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.P. Pavlov First Saint Petersburg State Medical University</institution></aff><aff><institution xml:lang="ru">Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">National Research Center — Institute of Immunology Federal Medical-Biological Agency</institution></aff><aff><institution xml:lang="ru">Государственный научный центр «Институт иммунологии»</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">RUDN University</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов имени Патриса Лумумбы</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Central State Medical Academy</institution></aff><aff><institution xml:lang="ru">Центральная государственная медицинская академия</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">South-Ural State Medical University</institution></aff><aff><institution xml:lang="ru">Южно-Уральский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">Saint-Petersburg State Pediatric Medical University</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский государственный педиатрический медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff8"><aff><institution xml:lang="en">Saint-Petersburg State University</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский государственный университет</institution></aff></aff-alternatives><aff-alternatives id="aff9"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education</institution></aff><aff><institution xml:lang="ru">Российская медицинская академия непрерывного профессионального образования</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2026-05-25" publication-format="electronic"><day>25</day><month>05</month><year>2026</year></pub-date><volume>23</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>258</fpage><lpage>263</lpage><history><date date-type="received" iso-8601-date="2026-05-12"><day>12</day><month>05</month><year>2026</year></date><date date-type="accepted" iso-8601-date="2026-05-15"><day>15</day><month>05</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, ABV-press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, АБВ-пресс</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">ABV-press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2028-05-25"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/17134">https://rusalljournal.ru/raj/article/view/17134</self-uri><abstract xml:lang="en"><p>The article presents the consensus opinion of experts on the role of 5% dexpanthenol preparations, particularly the original 5% dexpanthenol cream, in the comprehensive management of patients with inflammatory dermatoses such as atopic dermatitis and eczema. The material was prepared based on the results of the Expert Council held on December 17, 2025. The article reviews current concepts of the pathogenesis of these diseases with an emphasis on the central role of epidermal barrier disruption. The main approaches to restoring the skin barrier within existing therapy are described. Current clinical guidelines are analyzed and problem areas related to algorithms for the use of preparations that restore skin barrier function are identified. An overview of the evidence base for the multifaceted action of 5 % dexpanthenol, which has regenerating, anti-inflammatory, and epidermal barrier-restoring effects, is presented. The place of 5 % dexpanthenol in the treatment of atopic dermatitis is defined: as monotherapy in mild forms, and as part of combination and sequential therapy in moderate-to-severe cases. The final part of the paper formulates practical recommendations for the inclusion of dexpanthenol medicinal products in clinical algorithms for patient management.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлено согласованное мнение экспертов в отношении роли препаратов 5% декспантенола, в частности оригинального лекарственного препарата 5% декспантенола в форме крема, в комплексном ведении пациентов с воспалительными дерматозами, такими как атопический дерматит и экзема. Материал подготовлен по результатам экспертного совета, состоявшегося 17 декабря 2025 г. Рассмотрены современные взгляды на патогенез данных заболеваний с акцентом на центральную роль нарушения эпидермального барьера. Описаны основные подходы к восстановлению кожного барьера в рамках существующей терапии. Проанализированы действующие клинические рекомендации и выделены проблемные области, касающиеся алгоритмов применения препаратов, восстанавливающих барьерную функцию кожи. Представлен обзор доказательной базы по многофакторному действию 5 % декспантенола, который обладает регенерирующим, противовоспалительным и восстанавливающим эпидермальный барьер эффектами. Определено место 5 % декспантенола в терапии атопического дерматита: в качестве монотерапии при легких формах, в составе комбинированного и последовательного лечения при среднетяжелом и тяжелом течении. Сформулированы практические рекомендации по включению лекарственных препаратов декспантенола в клинические алгоритмы ведения пациентов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>eczema</kwd><kwd>atopic dermatitis</kwd><kwd>dexpanthenol</kwd><kwd>treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>экзема</kwd><kwd>атопический дерматит</kwd><kwd>декспантенол</kwd><kwd>лечение</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Brown SJ, McLean WH. One remarkable molecule: filaggrin. 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