<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">16989</article-id><article-id pub-id-type="doi">10.36691/RJA16989</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Monitoring of seasonal skin sensitivity to apple and IgE reactivity to birch pollen allergen Bet v 1 and apple allergen Mal d 1, in patients with birch pollen allergy</article-title><trans-title-group xml:lang="ru"><trans-title>Мониторинг сезонной IgE-реактивности к аллергенам пыльцы березы Bet v 1 и яблока Mal d 1 и кожной чувствительности к яблоку у пациентов с аллергией на пыльцу березы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5021-9276</contrib-id><contrib-id contrib-id-type="spin">2337-7930</contrib-id><name-alternatives><name xml:lang="en"><surname>Litovkina</surname><given-names>Alla O.</given-names></name><name xml:lang="ru"><surname>Литовкина</surname><given-names>Алла Олеговна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>dr.litovkina@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1302-4178</contrib-id><contrib-id contrib-id-type="spin">4874-8100</contrib-id><name-alternatives><name xml:lang="en"><surname>Smolnikov</surname><given-names>Evgeniy V.</given-names></name><name xml:lang="ru"><surname>Смольников</surname><given-names>Евгений Валентинович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>qweril2010@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3358-5087</contrib-id><contrib-id contrib-id-type="spin">5012-7242</contrib-id><name-alternatives><name xml:lang="en"><surname>Fedenko</surname><given-names>Elena S.</given-names></name><name xml:lang="ru"><surname>Феденко</surname><given-names>Елена Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>efedks@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">National Research Center – Institute of Immunology</institution></aff><aff><institution xml:lang="ru">Государственный научный центр «Институт иммунологии»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">People’s Friendship University of Russia named after Patrice Lumumba</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов имени Патриса Лумумбы</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-03-18" publication-format="electronic"><day>18</day><month>03</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-04-10" publication-format="electronic"><day>10</day><month>04</month><year>2025</year></pub-date><volume>22</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>115</fpage><lpage>121</lpage><history><date date-type="received" iso-8601-date="2024-12-10"><day>10</day><month>12</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2025-03-17"><day>17</day><month>03</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, PH “ABV-Press”</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, ООО «ИД «АБВ-пресс»</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">PH “ABV-Press”</copyright-holder><copyright-holder xml:lang="ru">ООО «ИД «АБВ-пресс»</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2027-04-10"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/16989">https://rusalljournal.ru/raj/article/view/16989</self-uri><abstract xml:lang="en"><p>Birch pollen allergy is widespread globally and ranks among the leading allergic diseases in Russia. Cross-reactive food allergy, often observed in patients with birch pollen allergy, is an underestimated issue that exacerbates the course of pollinosis. The presence of cross-reactive food allergy significantly impacts the quality of life of patients with pollinosis. Unlike reactions to pollen, reactions to plant foods can occur year-round and may sometimes have severe, even life-threatening manifestations (e.g., angioedema of the lips and tongue, laryngeal edema, urticaria, anaphylaxis). In many patients, сross-reactive food allergy symptoms first appear during or immediately after the pollen season. According to existing scientific data, this may be due to an increase in the levels of specific immunoglobulin E during the flowering season, both to the causative pollen allergens and to cross-reacting food allergens.</p> <p>The article presents two clinical cases of development of oral allergy syndrome after consuming raw apple during the birch flowering season, demonstrating possible differences in the mechanisms of cross-reactive food allergy to apple in patients sensitized to birch pollen allergen.</p></abstract><trans-abstract xml:lang="ru"><p>Аллергия на пыльцу березы распространена в мире и занимает одно из ведущих мест в России среди аллергических заболеваний. Перекрестная пищевая аллергия, часто наблюдаемая у пациентов с аллергией на березу, является недооцененной проблемой, усугубляющей течение поллиноза. Наличие перекрестной пищевой аллергии значительно влияет на качество жизни пациентов с поллинозом. В отличие от реакций на пыльцу реакции на растительные продукты могут проявляться в течение всего года и иногда имеют тяжелое, а порой даже угрожающее жизни течение (например, ангиоотеки губ и языка, отек гортани, крапивница, анафилаксия). У многих пациентов симптомы перекрестной пищевой аллергии впервые появляются во время или сразу после окончания сезона палинации. Согласно имеющимся научным данным это может быть обусловлено тем, что в сезон цветения повышается титр специфических иммуноглобулинов класса E как к причинно-значимым пыльцевым, так и к перекрестно-реагирующим пищевым аллергенам.</p> <p>В статье представлены 2 клинических случая развития орального аллергического синдрома при употреблении в пищу термически необработанного яблока в сезон цветения березы, демонстрирующих возможные различия в механизмах развития перекрестной пищевой аллергии к яблоку у пациентов, сенсибилизированных к аллергену пыльцы березы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>birch pollen</kwd><kwd>cross-reactive food allergy</kwd><kwd>oral allergy syndrome</kwd><kwd>Bet v 1</kwd><kwd>Mal d 1</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>пыльца березы</kwd><kwd>перекрестная пищевая аллергия</kwd><kwd>оральный аллергический синдром</kwd><kwd>Bet v 1</kwd><kwd>Mal d 1</kwd></kwd-group><funding-group><funding-statement xml:lang="en">This study was supported by the grant of the Russian Science Foundation No. 23-25-00413 (https://rscf.ru/en/project/23-25-00413/)</funding-statement><funding-statement xml:lang="ru">Работа выполнена за счет гранта Российского научного фонда № 23-25-00413 (https://rscf.ru/project/23-25-00413/)</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Biedermann T, Winther L, Till SJ, et al. Birch pollen allergy in Europe. Allergy. 2019;74(7):1237–1248. doi: 10.1111/all.13758</mixed-citation><mixed-citation xml:lang="ru">Biedermann T., Winther L., Till S.J., et al. Birch pollen allergy in Europe // Allergy. 2019. Vol. 74, No. 7. P. 1237–1248. doi: 10.1111/all.13758</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Litovkina AO, Fedenko ES, Elisutina OG. Cross-reactive food allergy to PR-10 homologues in birch pollen sensitized patients. Russian Journal of Allergy. 2018;15(6):18–25. (In Russ.). doi: 10.36691/RJA94</mixed-citation><mixed-citation xml:lang="ru">Литовкина А.О., Феденко Е.С., Елисютина О.Г. Перекрестная пищевая аллергия к Pr-10-белкам — гомологам Bet v 1 у больных, сенсибилизированных к пыльце березы // Российский аллергологический журнал. 2018. Т. 15, № 6. C. 18–25. doi: 10.36691/RJA94</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Kozulina IE, Kurbacheva OM, Ilina NI. Allergy today. Analysis of new epidemiological data. Russian Journal of Allergy. 2014;11(3):3–10. (In Russ.). doi: 10.36691/RJA483</mixed-citation><mixed-citation xml:lang="ru">Козулина И.Е., Курбачева О.М., Ильина Н.И. Аллергия сегодня. Анализ новых эпидемиологических данных // Российский аллергологический журнал. 2014. Т. 11, № 3. C. 3–10. doi: 10.36691/RJA483</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Elisyutina O, Lupinek C, Fedenko E, et al. IgE-reactivity profiles to allergen molecules in Russian children with and without symptoms of allergy revealed by micro-array analysis. Pediatr Allergy Immunol. 2021;32(2):251–263. doi: 10.1111/pai.13354</mixed-citation><mixed-citation xml:lang="ru">Elisyutina O., Lupinek C., Fedenko E., et al. IgE-reactivity profiles to allergen molecules in Russian children with and without symptoms of allergy revealed by micro-array analysis // Pediatr Allergy Immunol. 2021. Vol. 32, No. 2. P. 251–263. doi: 10.1111/pai.13354</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Litovkina AO, Byazrova MG, Smolnikov EV, et al. Characteristics of the molecular sensitization profiles in patients with birch pollen allergy and cross-reactive food allergy to PR-10 proteins. Russian Journal of Allergy. 2023;20(4):464–475 (In Russ.). doi: 10.36691/RJA16901</mixed-citation><mixed-citation xml:lang="ru">Литовкина А.О., Бязрова М.Г., Смольников Е.В., и др. Особенности молекулярного профиля сенсибилизации у пациентов с аллергией на пыльцу березы и перекрестной пищевой аллергией к PR-10 белкам // Российский аллергологический журнал. 2023. Т. 20, № 4. C. 464–475. doi: 10.36691/RJA16901</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Knyziak-Mędrzycka I, Majsiak E, Gromek W, et al. The sensitization profile for selected food allergens in Polish children assessed with the use of a precision allergy molecular diagnostic technique. Int J Mol Sci. 2024;25(2):825. doi: 10.3390/ijms25020825</mixed-citation><mixed-citation xml:lang="ru">Knyziak-Mędrzycka I., Majsiak E., Gromek W., et al. The sensitization profile for selected food allergens in Polish children assessed with the use of a precision allergy molecular diagnostic technique // Int J Mol Sci. 2024. Vol. 25, No. 2. P. 825. doi: 10.3390/ijms25020825</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Westman M, Lupinek C, Bousquet J, et al. Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence. J Allergy Clin Immunol. 2015;135(5):1199–1206.e1–11. doi: 10.1016/j.jaci.2014.10.042</mixed-citation><mixed-citation xml:lang="ru">Westman M., Lupinek C., Bousquet J., et al. Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence // J Allergy Clin Immunol. 2015. Vol. 135, No. 5. P. 1199–1206.e1–11. doi: 10.1016/j.jaci.2014.10.042</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Briceno Noriega D, Savelkoul HFJ, Jansen A, et al. Pollen sensitization can increase the allergic reaction to non-cross-reactive allergens in a soy-allergic patient. Int J Environ Res Public Health. 2023;20(11):6045. doi: 10.3390/ijerph20116045</mixed-citation><mixed-citation xml:lang="ru">Briceno Noriega D.B., Savelkoul H.F.J., Jansen A., et al. Pollen sensitization can increase the allergic reaction to non-cross-reactive allergens in a soy-allergic patient // Int J Environ Res Public Health. 2023. Vol. 20, No. 11. P. 6045. doi: 10.3390/ijerph20116045</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">Skamstrup Hansen K, Vieths S, Vestergaard H, et al. Seasonal variation in food allergy to apple. J Chromatogr B Biomed Sci Appl. 2001;756(1–2):19–32. doi: 10.1016/s0378-4347(01)00068-8</mixed-citation><mixed-citation xml:lang="ru">Skamstrup Hansen K., Vieths S., Vestergaard H., et al. Seasonal variation in food allergy to apple // J Chromatogr B Biomed Sci Appl. 2001. Vol. 756, No. 1–2. P. 19–32. doi: 10.1016/s0378-4347(01)00068-8</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Lam HCY, Jarvis D; ECRHS I Investigators. Seasonal variation in total and pollen-specific immunoglobulin E levels in the European Community Respiratory Health Survey. Clin Exp Allergy. 2021;51(8):1085–1088. doi: 10.1111/cea.13895</mixed-citation><mixed-citation xml:lang="ru">Lam H.C.Y., Jarvis D; ECRHS I Investigators. Seasonal variation in total and pollen-specific immunoglobulin E levels in the European Community Respiratory Health Survey // Clin Exp Allergy. 2021. Vol. 51, No. 8. P. 1085–1088. doi: 10.1111/cea.13895</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Magnusson J, Lin XP, Dahlman-Höglund A, et al. Seasonal intestinal inflammation in patients with birch pollen allergy. J Allergy Clin Immunol. 2003;112(1):45–50. doi: 10.1067/mai.2003.1604</mixed-citation><mixed-citation xml:lang="ru">Magnusson J., Lin X.P., Dahlman-H-glund A., et al. Seasonal intestinal inflammation in patients with birch pollen allergy // J Allergy Clin Immunol. 2003. Vol. 112, No. 1. P. 45–51. doi: 10.1067/mai.2003.1604</mixed-citation></citation-alternatives></ref></ref-list></back></article>
