Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press1695210.36691/RJA16952ReviewsНаучные обзорыResearch ArticleAspects of pathogenesis, differential and modifying approaches in cholinergic urticariaАспекты патогенеза, дифференциальных и модифицирующих подходов при холинергической крапивницеhttps://orcid.org/0000-0002-4022-35702588-5718MaltsevaNatalia P.МальцеваНаталья Петровна
Russian Federation
maltseva.natalia.p@gmail.comhttps://orcid.org/0000-0003-0520-09369000-6894RyabovaKseniya A.РябоваКсения Александровна
Russian Federation
acksinja@gmail.comhttps://orcid.org/0000-0001-8734-55274538-9397ZhernovYury V.ЖерновЮрий Владимирович
Russian Federation

MD, Dr. Sci. (Medicine), Professor

д-р мед. наук, профессор

zhernov_yu_v@staff.sechenov.ruhttps://orcid.org/0000-0002-3508-96022922-9398SebekinaOksana V.СебекинаОксана Владимировна
Russian Federation

MD. Cand. Sci. (Medicine), Assistant Professor

канд. мед. наук, доцент

sebekin1@mail.ruState Research Center of Dermatovenerology and CosmetologyГосударственный научный центр дерматовенерологии и косметологииThe First Sechenov Moscow State Medical University (Sechenov University)Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)Research Institute of Human Ecology and Environmental Hygiene named after A.N. Sysina, Centre for Strategic Planning and Management of Biomedical Health RisksНаучно-исследовательский институт экологии человека и гигиены окружающей среды имени А.Н. Сысина ФГБУ «Центр стратегического планирования и управления медико-биологическими рисками здоровью»Russian Medical Academy of Continuous Professional EducationРоссийская медицинская академия непрерывного профессионального образованияCity Clinical Hospital No. 24Городская клиническая больница № 2412122024281220242144794913105202405112024Copyright ©; 2024, Pharmarus Print MediaCopyright ©; 2024, Фармарус Принт Медиа2024Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/16952

Cholinergic urticaria is a subtype of chronic inducible urticaria mediated by hyper sweating and clinically manifested by urticarial elements, pruritus and angioedemas. This form of urticaria is of scientific interest considering its high prevalence in particular age groups, prolonged duration, distinct reduction in the quality of life of patients and high risk of developing life-threatening systemic reactions. There are types of anaphylaxis, also occurring due to increased sweating during physical activity. However, although clinical and laboratory characteristics have been described for each of these types, distinct differential diagnostic algorithms between these pathologies and systemic reactions in cholinergic urticaria have not yet been developed. Also, clear recommendations for modification of life style and limitation/elimination of the causal trigger for patients are currently open. These interventions are at the centre of therapy for all inducible forms of chronic urticaria. This article presents a review of the current literature and practical development of recommendations for specialists and patients.

Холинергическая крапивница – подтип хронической индуцируемой крапивницы, опосредуемый повышенным потоотделением и клинически проявляющийся возникновением уртикарных элементов, зуда кожи и ангиоотеков. Данная форма крапивницы представляет научный интерес ввиду ее высокой встречаемости в определенных возрастных группах, многолетней продолжительности, выраженного снижения качества жизни пациентов и высокого риска развития жизнеугрожающих системных реакций. Существуют виды анафилаксии, также возникающие вследствие повышенного потоотделения при физической нагрузке, – анафилаксия, индуцированная физической нагрузкой, и пшенице-зависимая анафилаксия вследствие физической нагрузки. Однако несмотря на то, что для каждого из этих видов описаны клинико-лабораторные особенности, четкие дифференциально-диагностические алгоритмы между данными патологиями и системными реакциями при холинергической крапивнице до сих пор не сформулированы. Также в настоящее время остается открытым вопрос о рациональных рекомендациях по модификации образа жизни, а именно мерах по ограничению/прекращению воздействия причинного триггера для данной группы пациентов. Подобные мероприятия занимают ведущее место в терапии всех индуцируемых форм хронической крапивницы. В статье представлены обзор актуальных литературных данных и практические разработки рекомендательных материалов как для пациентов, так и специалистов.

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