Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press1693710.36691/RJA16937Case reportsКлинические случаиResearch ArticleModern possibilities of allergy diagnostics in real clinical practiceСовременные возможности аллергодиагностики в реальной клинической практикеhttps://orcid.org/0000-0002-7571-54606289-0209NovikGennady A.НовикГеннадий Айзикович
Russian Federation

MD, Dr. Sci. (Med), Professor

д-р мед. наук, профессор

ga_novik@mail.ruhttps://orcid.org/0000-0003-3261-67185476-8497TamrazovaOlga B.ТамразоваОльга Борисовна
Russian Federation

MD, Dr. Sci. (Med), Professor

д-р мед. наук, профессор

anait_tamrazova@mail.ruhttps://orcid.org/0000-0001-7035-01002204-3465ZhdanovaMarina V.ЖдановаМарина Владимировна

MD, Cand. Sci. (Med.), Assistant Professor

канд. мед. наук, доцент

zhdanova-marina@rambler.ruhttps://orcid.org/0000-0002-4672-697X1563-1190TamrazovaAnait V.ТамразоваАнаит Вардановна
Russian Federation

MD

anaittamrazova@gmail.comhttps://orcid.org/0000-0001-9660-464X7127-9906FilimonovaOlga I.ФилимоноваОльга Игоревна
Russian Federation
ofilimonova.iit@gmail.comSaint Petersburg State Pediatric Medical UniversityСанкт-Петербургский государственный педиатрический медицинский университетPeoples' Friendship University of RussiaМедицинский институт ФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы»Central State Medical Academy of Department of Presidential AffairsЦентральная государственная медицинская академия Управления делами Президента Российской ФедерацииInternational pharmaceutical company "Innovatsionnye immunnye tekhnologii"Международная фармацевтическая компания «Инновационные иммунные технологии»03062024160620242123213321403202429052024Copyright ©; 2024, Pharmarus Print MediaCopyright ©; 2024, Фармарус Принт Медиа2024Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/16937

More than 20% of people worldwide suffer from allergic diseases. The high prevalence and wide range of provocative factors, which are increasing daily, complicate the diagnostic search. On the one hand, this leads to inadequately extensive dietary and lifestyle restrictions that reduce the quality of life for patients; on the other hand, it results in the failure to identify life-threatening allergens. The discovery of immunoglobulin E over 60 years ago initiated the search for specific biomarkers to etermine the causes of allergic diseases. Traditional methods of allergen diagnostics have several limitations that hinder the search for potential allergic disease triggers.

The article discusses modern laboratory approaches to multicomponent molecular allergen diagnostics, describes its differences from traditional diagnostic methods, and analyzes the advantages, prospects, limitations, and shortcomings of this method. It also presents a comparative characterization of the test systems available today.

The article presents four clinical cases that demonstrate the capabilities of the multicomponent ALEX 2 test system in diagnostics, choice of therapy tactics, and in forming further personalized recommendations for patients suffering from various allergic diseases.

Более 20% людей по всему миру страдают аллергическими заболеваниями. Высокая распространённость и широкий спектр провокационных факторов, количество которых растёт с каждым днём, затрудняют диагностический поиск. Это приводит, с одной стороны, к неадекватно обширным ограничениям рациона питания и образа жизни, которые снижают качество жизни пациентов, с другой ― к невыявлению опасных для жизни аллергенов. Открытие более 60 лет назад иммуноглобулина E положило начало поиску специфических биомаркеров для определения причин аллергических заболеваний. Традиционные методы аллергодиагностики имеют ряд ограничений, которые затрудняют поиск потенциальных триггеров аллергических заболеваний.

В статье рассматриваются современные лабораторные способы многокомпонентной молекулярной аллергодиагностики, описано её отличие от традиционных методов диагностики; рассматриваются преимущества и перспективы, ограничения и недостатки данного метода; представлена сравнительная характеристика существующих на сегодняшний день тест-систем.

В статье представлены четыре клинических случая, на примере которых наглядно показаны возможности использования многокомпонентной тест-системы ALEХ 2 в диагностике, выборе тактики терапии и формировании дальнейших персонифицированных рекомендаций для пациентов, страдающих различными аллергическими заболеваниями.

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