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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">16499</article-id><article-id pub-id-type="doi">10.36691/RJA16499</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">IgE mediated food allergy and celiac disease: An updated review</article-title><trans-title-group xml:lang="ru"><trans-title>IgE-опосредованная пищевая аллергия и целиакия: обновлённый обзор</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-3913-5219</contrib-id><name><surname>Ait Said</surname><given-names>Hasna</given-names></name><address><country country="MA">Morocco</country></address><bio xml:lang="en"><p>Molecular Engineering, Biotechnology and Innovation Team, Geo-Bio-Environment Engineering and Innovation Laboratory, Polydisciplinary Faculty of Taroudannt, Biotechnology, Environment and Health Team, Laboratory of Sciences of Health and Environment</p></bio><bio xml:lang="ru"><p>Команда молекулярной инженерии, биотехнологии и инноваций, Лаборатория гео-био-экологической инженерии и инноваций, полидисциплинарный факультет Таруданта, Группа биотехнологий, окружающей среды и здоровья, лаборатория наук о здоровье и окружающей среде</p></bio><email>hasna.aitsaid@edu.uiz.ac.ma</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0714-3245</contrib-id><name><surname>Elmoumou</surname><given-names>Lahcen</given-names></name><address><country country="MA">Morocco</country></address><bio xml:lang="en"><p>PhD, Assistant Professor, Molecular Engineering, Biotechnology and Innovation Team, Geo-Bio-Environment Engineering and Innovation Laboratory, Polydisciplinary Faculty of Taroudannt, Biotechnology, Environment and Health Team, Laboratory of Sciences of Health and Environment</p></bio><bio xml:lang="ru"><p>доцент, Команда молекулярной инженерии, биотехнологии и инноваций, Лаборатория гео-био-экологической инженерии и инноваций, полидисциплинарный факультет Таруданта, Группа биотехнологий, окружающей среды и здоровья, лаборатория наук о здоровье и окружающей среде</p></bio><email>enseignanttiznit2014@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3963-1366</contrib-id><name><surname>Guennouni</surname><given-names>Morad</given-names></name><address><country country="MA">Morocco</country></address><bio xml:lang="en"><p>MD, PhD, Cand. Sci. (Med.), Assistant Professor, Higher School of Education and Training, Science and Technology Team</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент, Высшая школа образования и подготовки, группа науки и технологий</p></bio><email>morad.guennouni@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6668-0537</contrib-id><name><surname>Rherissi</surname><given-names>Bouchra</given-names></name><address><country country="MA">Morocco</country></address><bio xml:lang="en"><p>PhD, Assistant Professor, Laboratory of Cell Biology and Molecular Genetics, Faculty of Sciences</p></bio><bio xml:lang="ru"><p>доцент, Лаборатория клеточной биологии и молекулярной генетики, факультет естественных наук</p></bio><email>b.rherissi@uiz.ac.ma</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7032-9704</contrib-id><name><surname>El Kadmiri</surname><given-names>Nadia</given-names></name><address><country country="MA">Morocco</country></address><bio xml:lang="en"><p>PhD, Dr. Sci. (Philosophical), Assistant Professor, Molecular Engineering, Biotechnology and Innovation Team, Geo-Bio-Environment Engineering and Innovation Laboratory, Polydisciplinary Faculty of Taroudannt</p></bio><bio xml:lang="ru"><p>д-р философии, доцент, Команда молекулярной инженерии, биотехнологии и инноваций, Лаборатория гео-био-экологической инженерии и инноваций, полидисциплинарный факультет Таруданта</p></bio><email>n.elkadmiri@uiz.ac.ma</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Ibn Zohr University</institution></aff><aff><institution xml:lang="ru">Университет Ибн Зора</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">High Institute of Nursing Professions and Health Techniques</institution></aff><aff><institution xml:lang="ru">Высший институт сестринских профессий и медицинских технологий</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Chouaib Doukkali University of El Jadida</institution></aff><aff><institution xml:lang="ru">Университет Эль-Джадиды имени Чуаиба Дуккали</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-12-21" publication-format="electronic"><day>21</day><month>12</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-12-02" publication-format="electronic"><day>02</day><month>12</month><year>2023</year></pub-date><volume>20</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>488</fpage><lpage>500</lpage><history><date date-type="received" iso-8601-date="2023-10-24"><day>24</day><month>10</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-11-28"><day>28</day><month>11</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Фармарус Принт Медиа</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2026-02-02"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/16499">https://rusalljournal.ru/raj/article/view/16499</self-uri><abstract xml:lang="en"><p>Celiac disease is a chronic autoimmune disorder that affects the small intestine. It is triggered in genetically predisposed individuals by consumption of gluten, a protein found in wheat, barley and rye. Celiac disease typically manifests in young pediatric patients as malabsorption of nutrients, gastrointestinal symptoms, and other health complications, which is associated with partial or total villous atrophy of the proximal small intestine. Food allergy, on the other hand, is an abnormal immune response to a specific food protein that causes inflammation and a range of symptoms, from mild hives to life-threatening anaphylaxis.</p> <p>Although the mechanisms behind celiac disease and food allergy are different, both conditions involve an immune response to food proteins. The current study revealed the possibility of IgE-A coexistence in celiac disease and food allergy screening should be considered for people with celiac disease, especially when symptoms persist even after implementing a gluten-free. However, the relationship between celiac disease and food allergy is not fully understood, and more research is needed to explore this link.</p> <p>This review aims to examine the available literature for the occurrence of food allergy in subjects with celiac disease.</p></abstract><trans-abstract xml:lang="ru"><p>Целиакия ― хроническое аутоиммунное заболевание, которое поражает тонкий кишечник. У генетически предрасположенной категории людей это заболевание возникает при потреблении в пищу глютена ― белка, содержащегося в пшенице, ячмене и ржи. Целиакия обычно проявляется у молодых пациентов детского возраста в виде нарушения всасывания питательных веществ, желудочно-кишечных симптомов и других осложнений, что связано с частичной или полной атрофией ворсинок проксимального отдела тонкого кишечника. С другой стороны, пищевая аллергия представляет собой аномальную иммунную реакцию на определённый пищевой белок, обусловливающую воспаление и ряд других симптомов от лёгкой крапивницы до жизнеугрожающей анафилаксии.</p> <p>Несмотря на то, что механизмы, лежащие в основе целиакии и пищевой аллергии, различны, оба состояния включают иммунный ответ на пищевые белки. Текущее исследование показало, что возможность сосуществования IgE-A при целиакии и скрининге на пищевую аллергию следует рассматривать для людей с целиакией, особенно когда симптомы сохраняются даже после введения элиминационной диеты с исключением глютена. Однако связь между целиакией и пищевой аллергией до конца не понятна, и для изучения этой связи необходимы дополнительные исследования.</p> <p>Целью данного обзора является изучение доступной литературы о возникновении пищевой аллергии у пациентов с целиакией.</p></trans-abstract><kwd-group xml:lang="en"><kwd>celiac disease</kwd><kwd>food allergy</kwd><kwd>immunoglobulin</kwd><kwd>IgE</kwd><kwd>physiopathology</kwd><kwd>review</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>целиакия</kwd><kwd>пищевая аллергия</kwd><kwd>иммуноглобулин</kwd><kwd>IgE</kwd><kwd>физиопатология</kwd><kwd>обзор</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Lengline H, Fabre A. Diagnostic de la maladie cœliaque chez l’enfant. Perfect En Pediatrie. 2022;5(2, Suppl 1):S2–6.</mixed-citation><mixed-citation xml:lang="ru">Lengline H., Fabre A. 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