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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1595</article-id><article-id pub-id-type="doi">10.36691/RJA1595</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Allergic rhinitis masks: Nasal polyposis in two preschool children</article-title><trans-title-group xml:lang="ru"><trans-title>Маски аллергического ринита: назальный полипоз у двух детей дошкольного возраста</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5999-7085</contrib-id><contrib-id contrib-id-type="spin">2399-5783</contrib-id><name-alternatives><name xml:lang="en"><surname>Macharadze</surname><given-names>Dali Sh.</given-names></name><name xml:lang="ru"><surname>Мачарадзе</surname><given-names>Дали Шотаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>dalim_a@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3309-4683</contrib-id><contrib-id contrib-id-type="spin">6284-8040</contrib-id><name-alternatives><name xml:lang="en"><surname>Popadiuk</surname><given-names>Valentin I.</given-names></name><name xml:lang="ru"><surname>Попадюк</surname><given-names>Валентин Иванович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Professor, Head of the Faculty of Continuing Medical Education</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, декан</p></bio><email>popadyuk-vi@rudn.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов имени Патриса Лумумбы</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-06-27" publication-format="electronic"><day>27</day><month>06</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-07-09" publication-format="electronic"><day>09</day><month>07</month><year>2023</year></pub-date><volume>20</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>250</fpage><lpage>258</lpage><history><date date-type="received" iso-8601-date="2023-01-01"><day>01</day><month>01</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-06-19"><day>19</day><month>06</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Фармарус Принт Медиа</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2025-07-09"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/1595">https://rusalljournal.ru/raj/article/view/1595</self-uri><abstract xml:lang="en"><p>Nasal symptoms such as nasal congestion, rhinorrhea, and cough are especially common in children. Despite symptomatic treatment (various nasal sprays, physiotherapy, antibiotics and topical glucocorticosteroids), nasal congestion can persist for a long time. In such cases, several diseases are most likely: adenoids, allergic rhinitis, various anomalies in the structure of intranasal structures and sinuses (for example, curvature of the nasal septum), rhinosinusitis (acute, subacute). If a child has two main symptoms ― congestion and discharge from the nose ― and such additional symptoms as a headache with predominant localization in the paranasal sinuses and a deterioration in smell (possibly also the taste of food) for more than 3 months, it is necessary to exclude the diagnosis of chronic rhinosinusitis, which can be combined with a nasal polyp.</p> <p>The purpose of this article is to analyze clinical cases of chronic rhinosinusitis with nasal polyp in two preschool children, including one of them with intolerance to non-steroidal anti-inflammatory drugs, and to raise physicians' awareness of this nosology.</p> <p>In children with symptoms such as prolonged nasal congestion, rhinorrhea, possibly impaired sense of smell, headache, intolerance to non-steroidal anti-inflammatory drugs, in the absence of sensitization and immunodeficiency, a computed tomography scan of the paranasal sinuses is recommended to exclude nasal polyp.</p></abstract><trans-abstract xml:lang="ru"><p>У детей особенно часто встречаются такие назальные симптомы, как заложенность носа, ринорея и кашель. Несмотря на симптоматическое лечение (назальные спреи, физиотерапия, приём антибиотиков и топических глюкокортикостероидов), заложенность носа может сохраняться длительно. В подобных случаях наиболее предполагаемыми являются несколько заболеваний: аденоиды, аллергический ринит, различные аномалии строения внутриносовых структур и пазух (например, искривление перегородки носа), риносинусит (острый, подострый). При наличии у ребёнка двух основных ― заложенности и отделяемого из носа ― и таких дополнительных симптомов, как головная боль с преимущественной локализацией в области околоносовых пазух и ухудшение обоняния (возможно также вкуса пищи), на протяжении более 3 месяцев необходимо исключить диагноз хронического риносинусита, который может сочетаться с назальным полипом.</p> <p>Цель данной статьи ― проанализировать клинические случаи хронического риносинусита с назальным полипом у двух детей дошкольного возраста, в том числе с непереносимостью нестероидных противовоспалительных препаратов у одного из них, и повысить осведомлённость врачей по данной нозологии.</p> <p>У детей с такими симптомами, как длительная заложенность носа, ринорея, нарушение обоняния, головная боль, непереносимость нестероидных противовоспалительных препаратов, при отсутствии сенсибилизации и иммунодефицита рекомендовано назначение компьютерной томографии околоносовых пазух с целью исключения назального полипа.</p></trans-abstract><kwd-group xml:lang="en"><kwd>children</kwd><kwd>chronic rhinosinusitis</kwd><kwd>nasal polyps</kwd><kwd>intolerance to non-steroidal anti-inflammatory drugs</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>хронический риносинусит</kwd><kwd>полипы носа</kwd><kwd>непереносимость нестероидных противовоспалительных препаратов</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Villwock J, Kuppersmith R. Diagnostic algorithm for evaluating nasal airway obstruction. Otolaryngol Clin N Am. 2018;51(5):867–872. doi: 10.1016/j.otc.2018.05.002</mixed-citation><mixed-citation xml:lang="ru">Villwock J., Kuppersmith R. Diagnostic algorithm for evaluating nasal airway obstruction // Otolaryngol Clin N Am. 2018. Vol. 51, N 5. P. 867–872. doi: 10.1016/j.otc.2018.05.002</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Brietzke S, Shin J, Choi S, et al. Clinical consensus statement: Pediatric chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2014; 151(4):542–553. doi: 10.1177/0194599814549302</mixed-citation><mixed-citation xml:lang="ru">Brietzke S., Shin J., Choi S., et al. Clinical consensus statement: Pediatric chronic rhinosinusitis // Otolaryngol Head Neck Surg. 2014. Vol. 151, N 4. P. 542–553. doi: 10.1177/0194599814549302</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Poachanukoon O, Nanthapisal S, Chaumrattanakul U. Pediatric acute and chronic rhinosinusitis: Comparison of clinical characteristics and outcome of treatment. Asian Pac J Allergy Immunol. 2012;30(2):146–151.</mixed-citation><mixed-citation xml:lang="ru">Poachanukoon O., Nanthapisal S., Chaumrattanakul U. Pediatric acute and chronic rhinosinusitis: Comparison of clinical characteristics and outcome of treatment // Asian Pac J Allergy Immunol. 2012. Vol. 30, N 2. P. 146–151.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Leo G, Triulzi F, Incorvaia C. Diagnosis of chronic rhinosinusitis. Pediatr Allergy Immunol. 2012;(Suppl 22):20–26. doi: 10.1111/j.1399-3038.2012.01320</mixed-citation><mixed-citation xml:lang="ru">Leo G., Triulzi F., Incorvaia C. Diagnosis of chronic rhinosinusitis // Pediatr Allergy Immunol. 2012. Vol. 23, Suppl. 22. P. 20–26. doi: 10.1111/j.1399-3038.2012.01320</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Magit A. Pediatric rhinosinusitis. Otolaryngol Clin N Am. 2014;47(5):733–746. doi: 10.1016/j.otc.2014.06.003</mixed-citation><mixed-citation xml:lang="ru">Magit A. Pediatric rhinosinusitis // Otolaryngol Clin N Am. 2014. Vol. 47, N 5. P. 733–746. doi: 10.1016/j.otc.2014.06.003</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Fokkens W, Lund V, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology. 2020; 58(Suppl S29):1–464. doi: 10.4193/Rhin20.401</mixed-citation><mixed-citation xml:lang="ru">Fokkens W., Lund V., Hopkins C., et al. European position paper on rhinosinusitis and nasal polyps 2020 // Rhinology. 2020. Vol. 58, Suppl. S29. P. 1–464. doi: 10.4193/Rhin20.401</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Heath J, Hartzell L, Putt C, Kennedy J. Chronic rhinosinusitis in children: Pathophysiology, evaluation, and medical management. Curr Allergy Asthma Rep. 2018;18(7):37. doi: 10.1007/s11882-018-0792-8</mixed-citation><mixed-citation xml:lang="ru">Heath J., Hartzell L., Putt C., Kennedy J. Chronic rhinosinusitis in children: Pathophysiology, evaluation, and medical management // Curr Allergy Asthma Rep. 2018. Vol. 18, N 7. P. 37. doi: 10.1007/s11882-018-0792-8</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Akdis C, Bachert C, Cingi C, et al. Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma &amp; Immunology. J Allergy Clin Immunol. 2013;131(6):1479–1490. doi: 10.1016/j.jaci.2013.02.036</mixed-citation><mixed-citation xml:lang="ru">Akdis C., Bachert C., Cingi C., et al. Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma &amp; Immunology // J Allergy Clin Immunol. 2013. Vol. 131, N 6. P. 1479–1490. doi: 10.1016/j.jaci.2013.02.036</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">Chandra R, Lin D, Tan B, et al. Chronic rhinosinusitis in the setting of other chronic inflammatory diseases. Am J Otolaryngol. 2011;32(5):388–391. doi: 10.1016/j.amjoto.2010.07.013</mixed-citation><mixed-citation xml:lang="ru">Chandra R., Lin D., Tan B., et al. Chronic rhinosinusitis in the setting of other chronic inflammatory diseases // Am J Otolaryngol. 2011. Vol. 32, N 5. P. 388–391. doi: 10.1016/j.amjoto.2010.07.013</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">McCormick J, Thompson H, Cho D, et al. Phenotypes in chronic rhinosinusitis. Curr Allergy Asthma Rep. 2020;20(7):20. doi: 10.1007/s11882-020-00916-6</mixed-citation><mixed-citation xml:lang="ru">McCormick J., Thompson H., Cho D., et al. Phenotypes in chronic rhinosinusitis // Curr Allergy Asthma Rep. 2020. Vol. 20, N 7. P. 20. doi: 10.1007/s11882-020-00916-6</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Poddighe D, Brambilla I, Licari A, Marseglia G. Pediatric rhinosinusitis and asthma. Respir Med. 2018;(141):94–99. doi: 10.1016/j.rmed.2018.06.016</mixed-citation><mixed-citation xml:lang="ru">Poddighe D., Brambilla I., Licari A., Marseglia G. Pediatric rhinosinusitis and asthma // Respir Med. 2018. N 141. P. 94–99. doi: 10.1016/j.rmed.2018.06.016</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Karakaya G, Celebioglu E, Kalyoncu AF. Non-steroidal anti-inflammatory drug hypersensitivity in adults and the factors associated with asthma. Respir Med. 2013;107(7):967–974. doi: 10.1016/j.rmed.2013.03.014</mixed-citation><mixed-citation xml:lang="ru">Karakaya G., Celebioglu E., Kalyoncu A.F. Non-steroidal anti-inflammatory drug hypersensitivity in adults and the factors associated with asthma // Respir Med. 2013. Vol. 107, N 7. P. 967–974. doi: 10.1016/j.rmed.2013.03.014</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Di Cicco M, Bizzoco F, Morelli E, et al. Nasal polyps in children: The early origins of a challenging adulthood condition. Children (Basel). 2021;8(11):997. doi: 10.3390/children8110997</mixed-citation><mixed-citation xml:lang="ru">Di Cicco M., Bizzoco F., Morelli E., et al. Nasal polyps in children: The early origins of a challenging adulthood condition // Children (Basel). 2021. Vol. 8, N 11. P. 997. doi: 10.3390/children8110997</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">Kowalski M, Agache I, Bavbek S, et al. Diagnosis and management of NSAID-exacerbated respiratory disease (N-ERD): A EAACI position paper. Allergy. 2019;74(1):28–39. doi: 10.1111/all.13599</mixed-citation><mixed-citation xml:lang="ru">Kowalski M., Agache I., Bavbek S., et al. Diagnosis and management of NSAID-exacerbated respiratory disease (N-ERD): A EAACI position paper // Allergy. 2019. Vol. 74, N 1. P. 28–39. doi: 10.1111/all.13599</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Varghese M, Lockey R. Aspirin-execerbated asthma. Allergy Asthma Clin Immunol. 2008;4(2):75–83. doi: 10.1186/1710-1492-4-2-75</mixed-citation><mixed-citation xml:lang="ru">Varghese M., Lockey R. Aspirin-execerbated asthma // Allergy Asthma Clin Immunol. 2008. Vol. 4, N 2. P. 75–83. doi: 10.1186/1710-1492-4-2-75</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">McGarry G, Melia L. Nasal polyps: An update. Br J Hosp Med (Lond). 2009;70(9):500–504. doi: 10.12968/hmed.2009.70.9.43865</mixed-citation><mixed-citation xml:lang="ru">McGarry G., Melia L. Nasal polyps: An update // Br J Hosp Med (Lond). 2009. Vol. 70, N 9. P. 500–504. doi: 10.12968/hmed.2009.70.9.43865</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">Dávila I, Rondón C, Navarro А, et al. Aeroallergen sensitization influences quality of life and comorbidities in patients with nasal polyposis. Am J Rhinol Allergy. 2012;26(5):126–131. doi: 10.2500/ajra.2012.26.3792</mixed-citation><mixed-citation xml:lang="ru">Dávila I., Rondón C., Navarro А., et al. Aeroallergen sensitization influences quality of life and comorbidities in patients with nasal polyposis // Am J Rhinol Allergy. 2012. Vol. 26, N 5. P. 126–131. doi: 10.2500/ajra.2012.26.3792</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">De Cock J, Zanca F, Canning J, et al. A comparative study for image quality and radiation dose of a cone beam computed tomography scanner and a multislice computed tomography scanner for paranasal sinus imaging. Eur Radiol. 2015;25(7):1891–900. doi: 10.1007/s00330-015-3593-7</mixed-citation><mixed-citation xml:lang="ru">De Cock J., Zanca F., Canning J., et al. A comparative study for image quality and radiation dose of a cone beam computed tomography scanner and a multislice computed tomography scanner for paranasal sinus imaging // Eur Radiol. 2015. Vol. 25, N 7. P. 1891–1900. doi: 10.1007/s00330-015-3593-7</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">Lawrence M, Palacios-Kibler T, Workman L, et al. Low serum IgE is a sensitive and specific marker for common variable immunodeficiency (CVID) // J Clin Immunol. 2018;38(3):225–233. doi: 10.1007/s10875- 018-0476-0</mixed-citation><mixed-citation xml:lang="ru">Lawrence M., Palacios-Kibler T., Workman L., et al. Low serum IgE is a sensitive and specific marker for common variable immunodeficiency (CVID) // J Clin Immunol. 2018. Vol. 38, N 3. P. 225–233. doi: 10.1007/s10875- 018-0476-0</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">Niu X, Wu Z, Xiao X, et al. The relationship between adenoid hypertrophy and gastroesophageal reflux disease: A meta-analysis. Medicine (Baltimore). 2018;97(41):e12540. doi: 10.1097/MD.0000000000012540</mixed-citation><mixed-citation xml:lang="ru">Niu X., Wu Z., Xiao X., et al. The relationship between adenoid hypertrophy and gastroesophageal reflux disease: A meta-analysis // Medicine (Baltimore). 2018. Vol. 97, N 41. P. e12540. doi: 10.1097/MD.0000000000012540</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">Macharadze DS, Sidorenko IV. The prevalence of intolerance to aspirin and aspirin asthma in children with bronchial asthma. Allergy Asthma Clin Immunol. 2002;(6):3. (In Russ).</mixed-citation><mixed-citation xml:lang="ru">Мачарадзе Д.Ш., Сидоренко И.В. Распространенность непереносимости аспирина и аспириновой астмы у детей с бронхиальной астмой // Аллергия, астма и клиническая иммунология. 2002. № 6. С. 3.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
