Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press159410.36691/RJA1594Systematic reviewsСистематические обзорыReview ArticleTropomyosins of the helminthes: Sensitization and association with allergic diseasesТропомиозины гельминтов: формирование сенсибилизации и связь с аллергической патологиейhttps://orcid.org/0000-0001-5084-22201123-3796RovitskayaVladislava A.РовицкаяВладислава Александровна
Russian Federation
rovitskayaVA@mail.ruhttps://orcid.org/0000-0002-7130-96095285-4593FedorovaOlga S.ФедороваОльга Сергеевна
Russian Federation

MD, Dr. Sci. (Med.), Professor

д.м.н., профессор

fedorova.os@ssmu.ruhttps://orcid.org/0000-0002-2234-53559835-1321KamaltynovaElena M.КамалтыноваЕлена Михайловна
Russian Federation

MD, Dr. Sci. (Med.), Professor

д.м.н., профессор

eleant21@yandex.ruSiberian State Medical UniversityСибирский государственный медицинский университет020320230604202320152623012202206022023Copyright ©; 2023, Rovitskaya V.A., Fedorova O.S., Kamaltynova E.M.Copyright ©; 2023, Ровицкая В.А., Федорова О.С., Камалтынова Е.М.2023Rovitskaya V.A., Fedorova O.S., Kamaltynova E.M.Ровицкая В.А., Федорова О.С., Камалтынова Е.М.https://creativecommons.org/licenses/by-nc-nd/4.0/https://rusalljournal.ru/raj/article/view/1594

The increase in the prevalence of allergic diseases has been a driver of the development of new technologies. Over the past two decades, significant progress in biochemistry and molecular allergology has contributed to the study of the structure of allergens and development of component-resolved diagnostics. Specifically, clinically significant families of allergens have been identified, including tropomyosin, which can cause various cross-IgE-mediated reactions. One of the risk factors for sensitization development is helminthiasis, which is common in different regions and population of endemic areas. The global prevalence of helminthiasis remains high. Approximately 1.5 billion people worldwide have chronic infections with at least one helminth.

This review aimed to analyze current studies determining the relationship between helminth infections and the development of sensitization to helminth tropomyosin and clinical course of allergic diseases.

The analysis of scientific publications described the relationship between helminth tropomyosin and the development of allergic diseases and sensitization in patients with parasitic infection. The PubMed database was used for the review. The review included original articles published between January 1, 2000, and December 31, 2021.

Рост аллергических заболеваний явился своего рода драйвером развития технологий в аллергологии: за последние два десятилетия значительный прогресс в области биохимии и молекулярной аллергологии способствовал изучению компонентов аллергенов и развитию компонентной аллергодиагностики. Так, выделены клинически значимые семейства аллергенов, среди которых тропомиозин, способный вызывать широкий спектр перекрёстных IgE-опосредованных реакций. Одним из факторов риска формирования сенсибилизации являются гельминтозы, которые распространены в разных регионах мира, что имеет особую актуальность для населения эндемичных районов. Глобальное распространение гельминтозов остаётся высоким: по оценкам Всемирной организации здравоохранения, 1,5 млрд человек во всём мире хронически инвазированы по крайней мере одним гельминтом.

Цель настоящего обзора ― анализ современных исследований, направленных на определение взаимосвязи гельминтных инвазий и развития сенсибилизации к тропомиозину гельминтов, а также клинического течения аллергических заболеваний.

Выполнен анализ научных публикаций, опубликованных за период с 1 января 2000 года по 31 декабря 2021 года. Поиск статей проводился в электронно-поисковой системе PubMed.

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