Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press15910.36691/RJA159ArticlesСтатьиResearch ArticleWhat is аsthma-COPD Overlap syndrome (ACOS), diagnostics and treatmentЧто такое Overlap синдром (ACOS), диагностика и лечениеFedoseevG BФедосеевГ Б

кафедра госпитальной терапии им. акад. М.В. Черноруцкого, доктор медицинских наук, профессор, член-корр. РАН, з.д.н. России.

fedoseevsp@mail.ruTrofimovV IТрофимовВ И

доктор медицинских наук, профессор, зав. кафедрой госпитальной терапии им. акад. М.В. Черноруцкого.

NegrutsaK VНегруцаК В

кафедра госпитальной терапии им. акад. М.В. Черноруцкого, аспирант.

TimchikV GТимчикВ Г

кандидат медицинских наук, врач функциональной диагностики отделения функциональной диагностики № 2 научно-клинического исследовательского центра.

GolubevaV IГолубеваВ И

биолог лаборатории клинической иммунологии и молекулярной диагностики.

AleksandrinV AАлександринВ А

кандидат медицинских наук, доцент кафедры госпитальной терапии им. акад. М.В. Черноруцкого.

RazumovskayaT SРазумовскаяТ С

ведущий инженер отделения функциональной диагностики № 2 научно-клинического исследовательского центра.

RabikU DРабикЮ Д

зав. отделением функциональной диагностики № 2 научно-клинического исследовательского центра.

KryakunovK NКрякуновК Н

кандидат медицинских наук, доцент кафедры госпитальной терапии им. акад. М.В. Черноруцкого.

Pavlov First Saint Petersburg State Medical UniversityПервый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова15042018152VOL 15, NO2 (2018)ТОМ 15, №2 (2018)172810032020Copyright ©; 2018, Pharmarus Print MediaCopyright ©; 2018, Фармарус Принт Медиа2018Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/159

175 patients were examined: 78 patients with bronchial asthma (BA), 39 with Asthma-COPD Overlap Syndrome (ACOS), 38 with chronic obstructive pulmonary disease (COPD) and 20 healthy individuals. A general clinical and laboratory examination was conducted, α1-antitrypsin (AAT), IgG and IgA to four bacterial antigens were determined, and pulmonary function test was studied. The clinical and spirometry data (characterizing the ACOS) were received. Negative association of AAT with respiratory function parameters in patients with ACOS, high levels of IgG antibodies to bacterial antigens and the lack of these connections in patients with BA and COPD allows us to consider ACOS to be independent nosological form related with microbial inflammation and marked by the AAT.

Обследованы 175 человек: 78 пациентов с бронхиальной астмой (БА), 39 - Asthma-COPD Overlap Syndrome (ACOS), 38 - хронической обструктивной болезнью легких (ХОБЛ), 20 практически здоровых. Проводилось общее клиническое и лабораторное обследование, определялись α1-антитрипсин (ААТ), IgG и IgE к четырем бактериальным антигенам, исследовалась ФВД. Получены соответствующие литературным, характеризующие ACOS, клинические и ФВД данные. Наличие у больных ACOS достоверной отрицательной связи ААТ с показателями ФВД и высоких уровней IgG к бактериальным антигенам и отсутствие этих связей у больных БА и ХОБЛ позволяет считать ACOS самостоятельной, отличной от БА и ХОБЛ, связанной с микробным воспалением и маркируемой ААТ нозологической формой.

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