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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1546</article-id><article-id pub-id-type="doi">10.36691/RJA1546</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical practice guidelines</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические рекомендации</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Resolution of the Working Meeting of Experts in “Dermatology”: Possibilities of systemic therapy of atopic dermatitis with selective immunosuppressants</article-title><trans-title-group xml:lang="ru"><trans-title>Резолюция Рабочего совещания экспертов по профилю «дерматология»: Возможности системной терапии атопического дерматита селективными иммунодепрессантами</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1450-4942</contrib-id><contrib-id contrib-id-type="spin">6708-7386</contrib-id><name-alternatives><name xml:lang="en"><surname>Bakulev</surname><given-names>Andrey L.</given-names></name><name xml:lang="ru"><surname>Бакулев</surname><given-names>Андрей Леонидович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>al_ba05@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7398-0562</contrib-id><contrib-id contrib-id-type="spin">1109-2810</contrib-id><name-alternatives><name xml:lang="en"><surname>Vishneva</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Вишнева</surname><given-names>Елена Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med)</p></bio><bio xml:lang="ru"><p>д.м.н.</p></bio><email>vishneva.e@yandex.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4609-2591</contrib-id><contrib-id contrib-id-type="spin">9567-1894</contrib-id><name-alternatives><name xml:lang="en"><surname>Elisyutina</surname><given-names>Olga G.</given-names></name><name xml:lang="ru"><surname>Елисютина</surname><given-names>Ольга Гурьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д.м.н.</p></bio><email>el-olga@yandex.ru</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3556-969X</contrib-id><contrib-id contrib-id-type="spin">6715-5650</contrib-id><name-alternatives><name xml:lang="en"><surname>Ilyina</surname><given-names>Natalya I.</given-names></name><name xml:lang="ru"><surname>Ильина</surname><given-names>Наталья Ивановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>instimmun@yandex.ru</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3805-8489</contrib-id><contrib-id contrib-id-type="spin">3604-6491</contrib-id><name-alternatives><name xml:lang="en"><surname>Karamova</surname><given-names>Arfenya E.</given-names></name><name xml:lang="ru"><surname>Карамова</surname><given-names>Арфеня Эдуардовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>karamova@cnikvi.ru</email><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6353-6644</contrib-id><contrib-id contrib-id-type="spin">3470-9306</contrib-id><name-alternatives><name xml:lang="en"><surname>Kokhan</surname><given-names>Muza M.</given-names></name><name xml:lang="ru"><surname>Кохан</surname><given-names>Муза Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>mkokhan@yandex.ru</email><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7625-0503</contrib-id><contrib-id contrib-id-type="spin">8771-4990</contrib-id><name-alternatives><name xml:lang="en"><surname>Kubanov</surname><given-names>Alexey A.</given-names></name><name xml:lang="ru"><surname>Кубанов</surname><given-names>Алексей Алексеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, член-корреспондент РАН</p></bio><email>alex@cnikvi.ru</email><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8211-1665</contrib-id><contrib-id contrib-id-type="spin">1837-2098</contrib-id><name-alternatives><name xml:lang="en"><surname>Monakhov</surname><given-names>Konstantin N.</given-names></name><name xml:lang="ru"><surname>Монахов</surname><given-names>Константин Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>knmonakhov@gmail.com</email><xref ref-type="aff" rid="aff7"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2209-7531</contrib-id><contrib-id contrib-id-type="spin">1312-2147</contrib-id><name-alternatives><name xml:lang="en"><surname>Namazova-Baranova</surname><given-names>Leyla S.</given-names></name><name xml:lang="ru"><surname>Намазова-Баранова</surname><given-names>Лейла Сеймуровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, академик РАН</p></bio><email>leyla.s.namazova@gmail.com</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7571-5460</contrib-id><contrib-id contrib-id-type="spin">6289-0209</contrib-id><name-alternatives><name xml:lang="en"><surname>Novik</surname><given-names>Gennadiy A.</given-names></name><name xml:lang="ru"><surname>Новик</surname><given-names>Геннадий Айзикович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>ga_novik@mail.ru</email><xref ref-type="aff" rid="aff8"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2482-1754</contrib-id><contrib-id contrib-id-type="spin">2500-7989</contrib-id><name-alternatives><name xml:lang="en"><surname>Olisova</surname><given-names>Olga Yu.</given-names></name><name xml:lang="ru"><surname>Олисова</surname><given-names>Ольга Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>olisovaolga@mail.ru</email><xref ref-type="aff" rid="aff9"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1149-7927</contrib-id><contrib-id contrib-id-type="spin">4607-0540</contrib-id><name-alternatives><name xml:lang="en"><surname>Revyakina</surname><given-names>Vera A.</given-names></name><name xml:lang="ru"><surname>Ревякина</surname><given-names>Вера Афанасьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>5356797@mail.ru</email><xref ref-type="aff" rid="aff10"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7610-6061</contrib-id><contrib-id contrib-id-type="spin">6807-7137</contrib-id><name-alternatives><name xml:lang="en"><surname>Sokolovskiy</surname><given-names>Evgeny V.</given-names></name><name xml:lang="ru"><surname>Соколовский</surname><given-names>Евгений Владиславович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>s40@mail.ru</email><xref ref-type="aff" rid="aff7"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3358-5087</contrib-id><contrib-id contrib-id-type="spin">5012-7242</contrib-id><name-alternatives><name xml:lang="en"><surname>Fedenko</surname><given-names>Elena S.</given-names></name><name xml:lang="ru"><surname>Феденко</surname><given-names>Елена Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>efedks@gmail.com</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8670-7223</contrib-id><contrib-id contrib-id-type="spin">4377-8101</contrib-id><name-alternatives><name xml:lang="en"><surname>Khobeysh</surname><given-names>Marianna M.</given-names></name><name xml:lang="ru"><surname>Хобейш</surname><given-names>Марианна Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>к.м.н., доцент</p></bio><email>mkhobeysh@yandex.ru</email><xref ref-type="aff" rid="aff7"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Central State Medical Academy of Department of Presidential Affairs</institution></aff><aff><institution xml:lang="ru">Центральная государственная медицинская академия Управления делами Президента Российской Федерации</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">The Russian National Research Medical University named after N.I. Pirogov</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Research Institute of Pediatrics and Children’s Health of Central Clinical Hospital of the Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт педиатрии и охраны здоровья детей ЦКБ РАН</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia</institution></aff><aff><institution xml:lang="ru">Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">State Scientific Center for Dermatovenereology and Cosmetology</institution></aff><aff><institution xml:lang="ru">Государственный научный центр дерматовенерологии и косметологии</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">Ural Research Institute for Dermatovenerology and Immunopatology</institution></aff><aff><institution xml:lang="ru">Уральский научно-исследовательский институт дерматовенерологии и иммунопатологии</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">Academician I.P. Pavlov First St. Petersburg State Medical University</institution></aff><aff><institution xml:lang="ru">Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова</institution></aff></aff-alternatives><aff-alternatives id="aff8"><aff><institution xml:lang="en">Saint-Petersburg State Pediatric Medical University</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский государственный педиатрический медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff9"><aff><institution xml:lang="en">First Sechenov Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution></aff></aff-alternatives><aff-alternatives id="aff10"><aff><institution xml:lang="en">Federal Research Center of Nutrition, Biotechnology and Food Safety</institution></aff><aff><institution xml:lang="ru">Федеральный исследовательский центр питания, биотехнологии и безопасности пищи</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2022-05-26" publication-format="electronic"><day>26</day><month>05</month><year>2022</year></pub-date><pub-date date-type="pub" iso-8601-date="2022-06-06" publication-format="electronic"><day>06</day><month>06</month><year>2022</year></pub-date><volume>19</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>259</fpage><lpage>269</lpage><history><date date-type="received" iso-8601-date="2022-05-17"><day>17</day><month>05</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-05-18"><day>18</day><month>05</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Bakulev A.L., Vishneva E.A., Elisyutina O.G., Ilyina N.I., Karamova A.E., Kokhan M.M., Kubanov A.A., Monakhov K.N., Namazova-Baranova L.S., Novik G.A., Olisova O.Y., Revyakina V.A., Sokolovskiy E.V., Fedenko E.S., Khobeysh M.M.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Бакулев А.Л., Вишнева Е.А., Елисютина О.Г., Ильина Н.И., Карамова А.Э., Кохан М.М., Кубанов А.А., Монахов К.Н., Намазова-Баранова Л.С., Новик Г.А., Олисова О.Ю., Ревякина В.А., Соколовский Е.В., Феденко Е.С., Хобейш М.М.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Bakulev A.L., Vishneva E.A., Elisyutina O.G., Ilyina N.I., Karamova A.E., Kokhan M.M., Kubanov A.A., Monakhov K.N., Namazova-Baranova L.S., Novik G.A., Olisova O.Y., Revyakina V.A., Sokolovskiy E.V., Fedenko E.S., Khobeysh M.M.</copyright-holder><copyright-holder xml:lang="ru">Бакулев А.Л., Вишнева Е.А., Елисютина О.Г., Ильина Н.И., Карамова А.Э., Кохан М.М., Кубанов А.А., Монахов К.Н., Намазова-Баранова Л.С., Новик Г.А., Олисова О.Ю., Ревякина В.А., Соколовский Е.В., Феденко Е.С., Хобейш М.М.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2024-06-06"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/1546">https://rusalljournal.ru/raj/article/view/1546</self-uri><abstract xml:lang="en"><p>On February 19, 2022, a working meeting of experts on the problem of atopic dermatitis was held in Moscow under the chairmanship of the Director of the State Scientific Center for Dermatovenereology and Cosmetology of the Ministry of Health of Russia, Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences A.A. Kubanov. Also in attendance was the Academician of the Russian Academy of Sciences, Chief Freelance Children’s Specialist in Preventive Medicine, Head of the Research Institute of Pediatrics and Children’s Health of the Central Clinical Hospital of the Russian Academy of Sciences of the Ministry of Science, and Higher Education of the Russian Federation, Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, L.S. Namazova-Baranova, and also the Deputy Director for Clinical Work ― Chief Physician of the Federal State Budgetary Institution “SSC” Institute of Immunology “FMBA of Russia” Doctor of Medical Sciences, Professor N.I. Ilyina.</p> <p>The meeting raised germane issues of providing medical care, reducing the burden of the disease, and improving the quality of life of patients with atopic dermatitis. New possibilities and principles of systemic therapy in patients with moderate and severe atopic dermatitis were discussed. We analyzed data on a new representative of the small molecule class — the selective Janus kinase 1 inhibitor, upadacitinib, which was registered in the Russian Federation in June 2021. This analysis aimed to determine its place in atopic dermatitis therapy algorithms and the possibility of the impact of its use as a therapy on the quality of life of patients in relation to the burden of diseases.</p> <p>The article has been published in several journals simultaneously with permission from authors and publishers. The parallel publication is available here: Capabilities of atopic dermatitis systemic therapy with selective immunosuppressors: resolution of the experts workshop of dermatology profile. <italic>Pediatric pharmacology</italic>. 2022;19(2):209–211. DOI: https://doi.org/10.15690/pf.v19i2.2424</p></abstract><trans-abstract xml:lang="ru"><p>19 февраля 2022 года в Москве состоялось Рабочее совещание экспертов по проблеме атопического дерматита под председательством директора ФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава России д.м.н., профессора, члена-корреспондента РАН А.А. Кубанова, академика РАН, главного вне штатного детского специалиста по профилактической медицине, руководителя НИИ педиатрии и охраны здоровья детей ЦКБ РАН Министерства науки и высшего образования РФ д.м.н., профессора, академика РАН Л.С. Намазовой- Барановой, заместителя директора по клинической работе, главного врача ФГБУ «ГНЦ «Институт иммунологии» ФМБА России» д.м.н., профессора Н.И. Ильиной.</p> <p>На совещании поднимались актуальные вопросы оказания медицинской помощи, уменьшения бремени заболевания и улучшения качества жизни пациентов с атопическим дерматитом. Обсуждались новые возможности и принципы системной терапии у пациентов со среднетяжёлым и тяжёлым атопическим дерматитом. Были проанализированы данные о новом представителе класса малых молекул ― селективном ингибиторе янус-киназы 1 упадацитинибе, который зарегистрирован в Российской Федерации в июне 2021 года, с целью определить его место в алгоритмах терапии атопического дерматита и возможности влияния терапии с его применением на качество жизни пациентов и бремя заболевания.</p> <p>Статья одновременно опубликована в нескольких научных журналах с согласия авторов и издателей. Параллельная публикация: Возможности системной терапии атопического дерматита селективными иммунодепрессантами: резолюция рабочего совещания экспертов по профилю «дерматология» // Педиатрическая фармакология. 2022. Т. 19, № 2. С. 209–211. DOI: https://doi.org/10.15690/pf.v19i2.2424</p></trans-abstract><kwd-group xml:lang="en"><kwd>atopic dermatitis</kwd><kwd>systemic therapy</kwd><kwd>Janus kinase inhibitors</kwd><kwd>upadacitinib</kwd><kwd>dupilumab</kwd><kwd>resolution</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>атопический дерматит</kwd><kwd>системная терапия</kwd><kwd>ингибиторы янус-киназ</kwd><kwd>упадацитиниб</kwd><kwd>дупилумаб</kwd><kwd>резолюция</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Clinical recommendations. Atopic dermatitis. 2021. (In Russ). Available from: https://cr.minzdrav.gov.ru. Accessed: 15.04.2022.</mixed-citation><mixed-citation xml:lang="ru">Клинические рекомендации. Атопический дерматит. 2021. Режим доступа: https://cr.minzdrav.gov.ru. Дата обращения: 15.04.2022.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Czarnowicki T, Krueger JG, Guttman-Yassky E. Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march. J Allergy Clin Immunol. 2017;139(6):1723–1734. doi: 10.1016/j.jaci.2017.04.004</mixed-citation><mixed-citation xml:lang="ru">Czarnowicki T., Krueger J.G., Guttman-Yassky E. Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march // J Allergy Clin Immunol. 2017. Vol. 139, N 6. Р. 1723–1734. doi: 10.1016/j.jaci.2017.04.004</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Krysanov IS, Krysanova VS, Karpov OI, Ermakova VY. The economic burden of severe atopic dermatitis in the Russian Federation. Qualitative Clin Pract. 2019;(4):4–14. (In Russ). doi: 10.1016/2588-0519-2019-4-4-14</mixed-citation><mixed-citation xml:lang="ru">Крысанов И.С., Крысанова В.С., Карпов О.И., Ермакова В.Ю. Экономическое бремя тяжелого атопического дерматита в Российской Федерации // Качественная клиническая практика. 2019. № 4. С. 4–14. doi: 10.1016/2588-0519-2019-4-4-14</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Faraz A, Vyas J, Finlay AY. Counting the burden: atopic dermatitis and health-related quality of life. Acta Derm Venereol. 2020;100(12):adv00161. doi: 10.2340/00015555-3511</mixed-citation><mixed-citation xml:lang="ru">Faraz A., Vyas J., Finlay A.Y. Counting the burden: atopic dermatitis and health-related quality of life // Acta Derm Venereol. 2020. Vol. 100, N 12. Р. adv00161. doi: 10.2340/00015555-3511</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Wohl Y, Wainstein J, Bar-Dayan Y. Atopic dermatitis in Israeli adolescents ― a large retrospective cohort study. Acta Derm Venereol. 2014;94(6):695–698. doi: 10.2340/00015555-1819</mixed-citation><mixed-citation xml:lang="ru">Wohl Y., Wainstein J., Bar-Dayan Y. Atopic dermatitis in Israeli adolescents ― a large retrospective cohort study // Acta Derm Venereol. 2014. Vol. 94, N 6. Р. 695–698. doi: 10.2340/00015555-1819</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Langenbruch A, Radtke M, Franzke N, et al. Quality of health care of atopic eczema in Germany: results of the national health care study AtopicHealth. J Eur Acad Dermatol Venereol. 2014;28(6): 719–726. doi: 10.1111/jdv.12154</mixed-citation><mixed-citation xml:lang="ru">Langenbruch A., Radtke M., Franzke N., et al. Quality of health care of atopic eczema in Germany: results of the national health care study AtopicHealth // J Eur Acad Dermatol Venereol. 2014. Vol. 28, N 6. Р. 719–726. doi: 10.1111/jdv.12154</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Kurbanov AA, Bogdanova EV. Organization and results of medical care in the profile of dermatovenerology in the Russian Federation. Results of 2018. Bulletin Dermatology Venereology. 2019;95(4):8–23. (In Russ). doi: 10.25208/0042-4609-2019-95-4-8-23</mixed-citation><mixed-citation xml:lang="ru">Кубанов А.А., Богданова Е.В. Организация и результаты оказания медицинской помощи по профилю «дерматовенерология» в Российской Федерации. Итоги 2018 года // Вестник дерматологии и венерологии. 2019. Т. 95, № 4. C. 8–23. doi: 10.25208/0042-4609-2019-95-4-8-23</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Wollenberg A, Barbarot S, Bieber T, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. JEADV. 2018;32(5):657–682. doi: 10.1111/jdv.14891</mixed-citation><mixed-citation xml:lang="ru">Wollenberg A., Barbarot S., Bieber T., et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I // JEADV. 2018. Vol. 32, N 5. Р. 657–682. doi: 10.1111/jdv.14891</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">Shrestha S, Miao R, Wang L, et al. Burden of atopic dermatitis in the United States: analysis of healthcare claims data in the commercial, medicare, and medical databases. Adv Ther. 2017; 34(8):1989–2006. doi: 10.1007/s12325-017-0582-z</mixed-citation><mixed-citation xml:lang="ru">Shrestha S., Miao R., Wang L., et al. Burden of atopic dermatitis in the United States: analysis of healthcare claims data in the commercial, medicare, and medi-cal databases // Adv Ther. 2017. Vol. 34, N 8. Р. 1989–2006. doi: 10.1007/s12325-017-0582-z</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Silverberg JI, Gelfand JM, Margolis DJ, et al. Association of atopic dermatitis with allergic, autoimmune, and cardiovascular comorbidities in US adults. Ann Allergy Asthma Immunol. 2018;121(5):604–612.e3. doi: 10.1016/j.anai.2018.07.042</mixed-citation><mixed-citation xml:lang="ru">Silverberg J.I., Gelfand J.M., Margolis D.J., et al. Association of atopic dermatitis with allergic, autoimmune, and cardiovascular comorbidities in US adults // Ann Allergy Asthma Immunol. 2018. Vol. 121, N 5. Р. 604–612.e3. doi: 10.1016/j.anai.2018.07.042</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Silverberg JI. Association between adult atopic dermatitis, cardiovascular disease, and increased heart attacks in three population-based studies. Allergy. 2015;70(10):1300–1308. doi: 10.1111/all.12685</mixed-citation><mixed-citation xml:lang="ru">Silverberg J.I. Association between adult atopic dermatitis, cardiovascular disease, and increased heart attacks in three population-based studies // Allergy. 2015. Vol. 70, N 10. Р. 1300–1308. doi: 10.1111/all.12685</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Schmitt J, Schwarz K, Baurecht H, et al. Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. J Allergy Clin Immunol. 2016;137(1):130–136. doi: 10.1016/j.jaci.2015.06.029</mixed-citation><mixed-citation xml:lang="ru">Schmitt J., Schwarz K., Baurecht H., et al. Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes // J Allergy Clin Immunol. 2016. Vol. 137, N 1. Р. 130–136. doi: 10.1016/j.jaci.2015.06.029</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Sánchez-Pérez J, Daudén-Tello E, Mora AM, Lara Surinyac N. Impact of atopic dermatitis on health-related quality of life in Spanish children and adults: the PSEDA study. Actas Dermosifiliogr. 2013;104(1):44–52. doi: 10.1016/j.ad.2012.03.008</mixed-citation><mixed-citation xml:lang="ru">Sánchez-Pérez J., Daudén-Tello E., Mora A.M., Lara Surinyac N. Impact of atopic dermatitis on health-related quality of life in Spanish children and adults: the PSEDA study // Actas Dermosifiliogr. 2013. Vol. 104, N 1. Р. 44–52. doi: 10.1016/j.ad.2012.03.008</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">Narala S, Hata TR. Adult atopic dermatitis with comorbid atopic disease is associated with increased risk of infections: a population-based cross-sectional study. Dermatol Ther (Heidelb). 2017;7(1): 111–121. doi: 10.1007/s13555-017-0172-7</mixed-citation><mixed-citation xml:lang="ru">Narala S., Hata T.R. Adult atopic dermatitis with comorbid atopic disease is associated with increased risk of infections: a population-based cross-sectional study // Dermatol Ther (Heidelb). 2017. Vol. 7, N 1. Р. 111–121. doi: 10.1007/s13555-017-0172-7</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Paller A, Jaworski JC, Simpson EL, et al. Major comorbidities of atopic dermatitis: beyond allergic disorders. Am J Clin Dermatol. 2018;19(6):821–838. doi: 10.1007/s40257-018-0383-4</mixed-citation><mixed-citation xml:lang="ru">Paller A., Jaworski J.C., Simpson E.L., et al. Major comorbidities of atopic dermatitis: beyond allergic disorders // Am J Clin Dermatol. 2018. Vol. 19, N 6. Р. 821–838. doi: 10.1007/s40257-018-0383-4</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">Acharya P, Mathur M. Association of atopic dermatitis with vitiligo: a systematic review and meta-analysis. J Cosmet Dermatol. 2020;19(8):2016–2020. doi: 10.1111/jocd.13263</mixed-citation><mixed-citation xml:lang="ru">Acharya P., Mathur M. Association of atopic dermatitis with vitiligo: a systematic review and meta-analysis // J Cosmet Dermatol. 2020. Vol. 19, N 8. Р. 2016–2020. doi: 10.1111/jocd.13263</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">Mocanu M, Vâta D, Alexa AI, et al. Atopic dermatitis ― beyond the skin. Diagnostics. 2021;11(9):1553. doi: 10.3390/diagnostics11091553</mixed-citation><mixed-citation xml:lang="ru">Mocanu M., Vâta D., Alexa A.I., et al. Atopic dermatitis ― beyond the skin // Diagnostics. 2021. Vol. 11, N 9. Р. 1553. doi: 10.3390/diagnostics11091553</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">Whiteley J, Emir B, Seitzman R, Makinson G. The burden of atopic dermatitis in US adults: results from the 2013 National Health and Wellness Survey. Curr Med Res Opin. 2016;32(10):1645–1651. doi: 10.1080/03007995.2016.1195733</mixed-citation><mixed-citation xml:lang="ru">Whiteley J., Emir B., Seitzman R., Makinson G. The burden of atopic dermatitis in US adults: results from the 2013 National Health and Wellness Survey // Curr Med Res Opin. 2016. Vol. 32, N 10. Р. 1645–1651. doi: 10.1080/03007995.2016.1195733</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">Augustin M, Radtke MA, Glaeske G, et al. Epidemiology and comorbidity in children with psoriasis and atopic eczema. Dermatology. 2015;231(1):35–40. doi: 10.1159/000381913</mixed-citation><mixed-citation xml:lang="ru">Augustin M., Radtke M.A., Glaeske G., et al. Epidemiology and comorbidity in children with psoriasis and atopic eczema // Dermatology. 2015. Vol. 231, N 1. Р. 35–40. doi: 10.1159/000381913</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">Silverberg NB. A practical overview of pediatric atopic dermatitis, part 3: comorbidities, and measurement of disease burden. Cutis. 2016;97(6):408–412.</mixed-citation><mixed-citation xml:lang="ru">Silverberg N.B. A practical overview of pediatric atopic dermatitis, part 3: comorbidities, and measurement of disease burden // Cutis. 2016. Vol. 97, N 6. Р. 408–412.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">Guttman-Yassky E, Krueger JG, Lebwohl MG. Systemic immune mechanisms in atopic dermatitis and psoriasis with implications for treatment. Exp Dermatol. 2018;27(4):409–417. doi: 10.1111/exd.13336</mixed-citation><mixed-citation xml:lang="ru">Guttman-Yassky E., Krueger J.G., Lebwohl M.G. Systemic immune mechanisms in atopic dermatitis and psoriasis with implications for treatment // Exp Dermatol. 2018. Vol. 27, N 4. Р. 409–417. doi: 10.1111/exd.13336</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">Darlenski R, Kazandjieva J, Hristakieva E, et al. Atopic dermatitis as a systemic disease. Clin Dermatol. 2014;32(3):409–413. doi: 10.1016/j.clindermatol.2013.11.007</mixed-citation><mixed-citation xml:lang="ru">Darlenski R., Kazandjieva J., Hristakieva E., et al. Atopic dermatitis as a systemic disease // Clin Dermatol. 2014. Vol. 32, N 3. P. 409–413. doi: 10.1016/j.clindermatol.2013.11.007</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">Oliveira C, Torres T. More than skin deep: the systemic nature of atopic dermatitis. Eur J Dermatol. 2019;29(3):250–258. doi: 10.1684/ejd.2019.3557</mixed-citation><mixed-citation xml:lang="ru">Oliveira C., Torres T. More than skin deep: the systemic nature of atopic dermatitis // Eur J Dermatol. 2019. Vol. 29, N 3. Р. 250–258. doi: 10.1684/ejd.2019.3557</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">Brunner P, Silverberg JI, Guttman-Yassky E, et al. Increasing comorbidities suggest that atopic dermatitis is a systemic disorder. J Invest Dermatol. 2017;137(1):18–25. doi: 10.1016/j.jid.2016.08.022</mixed-citation><mixed-citation xml:lang="ru">Brunner P., Silverberg J.I., Guttman-Yassky E., et al. Increasing comorbidities suggest that atopic dermatitis is a systemic disorder // J Invest Dermatol. 2017. Vol. 137, N 1. P. 18–25. doi: 10.1016/j.jid.2016.08.022</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">Wollenberg A, Christen-Zäch S, Taieb A, et al. ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children. J Eur Acad Dermatol Venereol. 2020;34(12):2717–2744. doi: 10.1111/jdv.16892</mixed-citation><mixed-citation xml:lang="ru">Wollenberg A., Christen-Zäch S., Taieb A., et al. ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children // J Eur Acad Dermatol Venereol. 2020. Vol. 34, N 12. Р. 2717–2744. doi: 10.1111/jdv.16892</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">Smolkin YS, Masalsky SS, Smolkina OY. Questions of the use of biological therapy in atopic dermatitis: emphasis on dupilumab. Allergology Immunology Pediatrics. 2020;61(2):27–40. (In Russ). doi: 10.24411/2500-1175-2020-10005</mixed-citation><mixed-citation xml:lang="ru">Смолкин Ю.С., Масальский С.С., Смолкина О.Ю. Вопросы применения биологической терапии при атопическом дерматите: акцент на дупилумаб // Аллергология и иммунология в педиатрии. 2020. Т. 61, № 2. С. 27–40. doi: 10.24411/2500-1175-2020-10005.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">Megna M, Napolitano M, Patruno C, et al. Systemic treatment of adult atopic dermatitis: a review. Dermatol Ther (Heidelb). 2017;7(1):1–23. doi: 10.1007/s13555-016-0170-1</mixed-citation><mixed-citation xml:lang="ru">Megna M., Napolitano M., Patruno C., et al. Systemic treatment of adult atopic dermatitis: a review // Dermatol Ther (Heidelb). 2017. Vol. 7, N 1. Р. 1–23. doi: 10.1007/s13555-016-0170-1</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">Beck LA, Thaçi D, Hamilton JD, et al. Dupilumab treatment in adults with moderate-to-severe atopic dermatitis. N Engl J Med. 2014;371(2):130–139. doi: 10.1056/NEJMoa1314768</mixed-citation><mixed-citation xml:lang="ru">Beck L.A., Thaçi D., Hamilton J.D., et al. Dupilumab treatment in adults with moderate-to-severe atopic dermatitis // N Engl J Med. 2014. Vol. 371, N 2. Р. 130–139. doi: 10.1056/NEJMoa1314768</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">Wollenberg A, Barbarot S, Bieber T, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol. 2018;32(5):657–682. doi: 10.1111/jdv.14891</mixed-citation><mixed-citation xml:lang="ru">Wollenberg A., Barbarot S., Bieber T., et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I // J Eur Acad Dermatol Venereol. 2018. Vol. 32, N 5. Р. 657–682. doi: 10.1111/jdv.14891</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">Drucker AM, Eyerich K, de Bruin-Weller MS, et al. Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement. Br J Dermatol. 2018;178(3):768–775. doi: 10.1111/bjd.15928</mixed-citation><mixed-citation xml:lang="ru">Drucker A.M., Eyerich K., de Bruin-Weller M.S., et al. Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement // Br J Dermatol. 2018. Vol. 178, N 3. Р. 768–775. doi: 10.1111/bjd.15928</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">Instructions for the medical use of the drug Mycophenolate mofetil. (In Russ). Available from: https://grls.rosminzdrav.ru/grls.aspx?s=Мофетил&amp;m=mnn. Accessed: 15.04.2022.</mixed-citation><mixed-citation xml:lang="ru">Инструкция по медицинскому применению лекарственного препарата микофенолата мофетил. Режим доступа: https://grls.rosminzdrav.ru/grls.aspx?s=Мофетил&amp;m=mnn. Дата обращения: 15.04.2022.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">Instructions for the medical use of the drug Azathioprine. (In Russ). Available from: https://grls.rosminzdrav.ru/grls.aspx?s=Азатиоприн&amp;m=mnn. Accessed: 15.04.2022.</mixed-citation><mixed-citation xml:lang="ru">Инструкция по медицинскому применению лекарственного препарата азатиоприн. Режим доступа: https://grls.rosminzdrav.ru/grls.aspx?s=Азатиоприн&amp;m=mnn. Дата обращения: 15.04.2022.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">Instructions for the medical use of the drug Methotrexate. (In Russ). Available from: https://grls.rosminzdrav.ru/grls.aspx?s=Метотрексат&amp;m=mnn. Accessed: 15.04.2022.</mixed-citation><mixed-citation xml:lang="ru">Инструкция по медицинскому применению лекарственного препарата метотрексат. Режим доступа: https://grls.rosminzdrav.ru/grls.aspx?s=Метотрексат&amp;m=mnn. Дата обращения: 15.04.2022.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">Werfel T, Heratizadeh A, Aberer W, et al. Update “Systemic treatment of atopic dermatitis” of the S2k-guideline on atopic dermatitis. J Dtsch Dermatol Ges. 2021;19(1):151–168. doi: 10.1111/ddg.14371</mixed-citation><mixed-citation xml:lang="ru">Werfel T., Heratizadeh A., Aberer W., et al. Update «Systemic treatment of atopic dermatitis» of the S2k-guideline on atopic dermatitis // J Dtsch Dermatol Ges. 2021. Vol. 19, N 1. Р. 151–168. doi: 10.1111/ddg.14371</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">Instructions for medical use of the drug Dupixentt®. (In Russ). Available from: http://grls.rosminzdrav.ru/Default.aspx. Accessed: 15.04.2022.</mixed-citation><mixed-citation xml:lang="ru">Инструкция по медицинскому применению лекарственного препарата Дупиксентт®. Режим доступа: http://grls.rosminzdrav.ru/Default.aspx. Дата обращения: 15.04.2022.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">Instructions for the medical use of the drug Olumiant®. (In Russ). Available from: http://grls.rosminzdrav.ru/Default.aspx. Accessed: 15.04.2022.</mixed-citation><mixed-citation xml:lang="ru">Инструкция по медицинскому применению лекарственного препарата Олумиант®. Режим доступа: http://grls.rosminzdrav.ru/Default.aspx. Дата обращения: 15.04.2022.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">Instructions for the medical use of the drug SHANVAK 15 mg. (In Russ). Available from: http://grls.rosminzdrav.ru/Default.aspx. Accessed: 15.04.2022.</mixed-citation><mixed-citation xml:lang="ru">Инструкция по медицинскому применению лекарственного препарата РАНВЭК 15 мг. Режим доступа: http://grls.rosminzdrav.ru/Default.aspx. Дата обращения: 15.04.2022.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">Identification of candidates for systemic therapy in clinical trials of advanced systemic methods of treatment of atopic dermatitis phase 3. (In Russ). Available from: https://www.clinicaltrials.gov/ct2/show/NCT02277743; https://www.clinicaltrials.gov/ct2/show/NCT03349060; https://www.clinicaltrials.gov/ct2/show/NCT03435081. Accessed: 15.04.2022.</mixed-citation><mixed-citation xml:lang="ru">Определение кандидатов на системную терапию в клинических исследованиях передовых системных методов лечения атопического дерматита 3-й фазы. Режим доступа: https://www.clinicaltrials.gov/ct2/show/NCT02277743; https://www.clinicaltrials.gov/ct2/show/NCT03349060; https://www.clinicaltrials.gov/ct2/show/NCT03435081. Дата обращения: 15.04.2022.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">Sidbury R, Davis DM, Cohen DE, et al. Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents. J Am Acad Dermatol. 2014;71(2):327–349. doi: 10.1016/j.jaad.2014.03.030</mixed-citation><mixed-citation xml:lang="ru">Sidbury R., Davis D.M., Cohen D.E., et al. Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents // J Am Acad Dermatol. 2014. Vol. 71, N 2. Р. 327–349. doi: 10.1016/j.jaad.2014.03.030</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">Kok WL, Yew YW, Thng TG. Comorbidities associated with severity of atopic dermatitis in young adult males: a national cohort study. Acta Derm Venereol. 2019;99(7):652–656. doi: 10.2340/00015555-3175</mixed-citation><mixed-citation xml:lang="ru">Kok W.L., Yew Y.W., Thng T.G. Comorbidities associated with severity of atopic dermatitis in young adult males: a national cohort study // Acta Derm Venereol. 2019. Vol. 99, N 7. Р. 652–656. doi: 10.2340/00015555-3175</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">Katayama I, Kohno Y, Akiyama K, et al. Japanese guideline for atopic dermatitis 2014. Allergol Int. 2014;63(3):377–398. doi: 10.2332/allergolint.14-RAI-0769</mixed-citation><mixed-citation xml:lang="ru">Katayama I., Kohno Y., Akiyama K., et al. Japanese guideline for atopic dermatitis 2014 // Allergol Int. 2014. Vol. 63, N 3. Р. 377–398. doi: 10.2332/allergolint.14-RAI-0769</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">Saeki H, Nakahara T, Tanaka A, et al. Clinical practice guidelines for the management of atopic dermatitis 2016. J Dermatol. 2016; 43(10):1117–1145. doi: 10.1111/1346-8138.13392</mixed-citation><mixed-citation xml:lang="ru">Saeki H., Nakahara T., Tanaka A., et al. Clinical practice guidelines for the management of atopic dermatitis 2016 // J Dermatol. 2016. Vol. 43, N 10. Р. 1117–1145. doi: 10.1111/1346-8138.13392</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">The AAAAI offers information on Eczema (Atopic Dermatitis) symptoms, diagnosis, treatment and management. Available from: https://www.aaaai.org/tools-for-the-public/conditions-library/allergies/eczema-(atopic-dermatitis)-overview. Accessed: 15.04.2022.</mixed-citation><mixed-citation xml:lang="ru">The AAAAI offers information on Eczema (Atopic Dermatitis) symptoms, diagnosis, treatment &amp; management. Режим доступа: https://www.aaaai.org/tools-for-the-public/conditions-library/allergies/eczema-(atopic-dermatitis)-overview. Дата обращения: 15.04.2022.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">Katoh N, Ohya Y, Ikeda M, et al. Clinical practice guidelines for the management of atopic dermatitis 2018. J Dermatol. 2019;46(12):1053–1101. doi: 10.1111/1346-8138.15090</mixed-citation><mixed-citation xml:lang="ru">Katoh N., Ohya Y., Ikeda M., et al. Clinical practice guidelines for the management of atopic dermatitis 2018 // J Dermatol. 2019. Vol. 46, N 12. Р. 1053–1101. doi: 10.1111/1346-8138.15090</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">Krader C, Pharm BS. Systemic Treatment for Pediatric AD. Dermatology Times. 2021;42(7).</mixed-citation><mixed-citation xml:lang="ru">Krader C., Pharm B.S. Systemic Treatment for Pediatric AD // Dermatology Times. 2021. Vol. 42, N 7.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">Nygaard U, Vestergaard C, Deleuran M. Systemic treatment of severe atopic dermatitis in children and adults. Current Treatment Options Allergy. 2014;1(4):1–13. doi 10.1007/s40521-014-0032-y</mixed-citation><mixed-citation xml:lang="ru">Nygaard U., Vestergaard C., Deleuran M. Systemic treatment of severe atopic dermatitis in children and adults // Current Treatment Options Allergy. 2014. Vol. 1, N 4. Р. 1–13. doi 10.1007/s40521-014-0032-y</mixed-citation></citation-alternatives></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">Instructions for the medical use of the drug Cyclosporine. (In Russ). Available from: http://grls.rosminzdrav.ru/Default.aspx. Accessed: 15.04.2022.</mixed-citation><mixed-citation xml:lang="ru">Инструкция по медицинскому применению лекарственного препарата циклоспорин. Режим доступа: http://grls.rosminzdrav.ru/Default.aspx. Дата обращения: 15.04.2022.</mixed-citation></citation-alternatives></ref><ref id="B48"><label>48.</label><citation-alternatives><mixed-citation xml:lang="en">Simpson EL, Bieber T, Guttman-Yassky E, et al.; SOLO 1 and SOLO 2 Investigators. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N Engl J Med. 2016;375(24):2335–2348. doi: 10. 1056/NEJMoa1610020</mixed-citation><mixed-citation xml:lang="ru">Simpson E.L., Bieber T., Guttman-Yassky E., et al.; SOLO 1 and SOLO 2 Investigators. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis // N Engl J Med. 2016. Vol. 375, N 24. Р. 2335–2348. doi: 10. 1056/NEJMoa1610020</mixed-citation></citation-alternatives></ref><ref id="B49"><label>49.</label><citation-alternatives><mixed-citation xml:lang="en">De Wijs LE, Bosma AL, Erler NS, et al. Effectiveness of dupilumab treatment in 95 patients with atopic dermatitis: daily practice data. Br J Dermatol. 2020;182(2):418–426. doi: 10.1111/bjd.18179</mixed-citation><mixed-citation xml:lang="ru">De Wijs L.E., Bosma A.L., Erler N.S., et al. Effectiveness of dupilumab treatment in 95 patients with atopic dermatitis: daily practice data // Br J Dermatol. 2020. Vol. 182, N 2. Р. 418–426. doi: 10.1111/bjd.18179</mixed-citation></citation-alternatives></ref><ref id="B50"><label>50.</label><citation-alternatives><mixed-citation xml:lang="en">Faiz S, Giovannelli J, Podevin C, et al. Effectiveness and safety of dupilumab for the treatment of atopic dermatitis in a real-life French multicenter adult cohort. J Am Acad Dermatol. 2019;81(1):143–151. doi: 10.1016/j.jaad.2019.02.053</mixed-citation><mixed-citation xml:lang="ru">Faiz S., Giovannelli J., Podevin C., et al. Effectiveness and safety of dupilumab for the treatment of atopic dermatitis in a real-life French multicenter adult cohort // J Am Acad Dermatol. 2019. Vol. 81, N 1. Р. 143–151. doi: 10.1016/j.jaad.2019.02.053</mixed-citation></citation-alternatives></ref><ref id="B51"><label>51.</label><citation-alternatives><mixed-citation xml:lang="en">McKenzie PL, Rangu S, Treat JR, Castelo-Soccio L. Experience using dupilumab for pediatric atopic dermatitis at a tertiary care center: Inadequate response and adverse events. Pediatr Dermatol. 2021;38(5):1178–1184. doi: 10.1111/pde.14799</mixed-citation><mixed-citation xml:lang="ru">McKenzie P.L., Rangu S., Treat J.R., Castelo-Soccio L. Experience using dupilumab for pediatric atopic dermatitis at a tertiary care center: Inadequate response and adverse events // Pediatr Dermatol. 2021. Vol. 38, N 5. P. 1178–1184. doi: 10.1111/pde.14799</mixed-citation></citation-alternatives></ref><ref id="B52"><label>52.</label><citation-alternatives><mixed-citation xml:lang="en">Narla S, Silverberg JI, Simpson EL. Management of inadequate response and adverse effects to dupilumab in atopic dermatitis. J Am acad Dermatol. 2022;86(3):628–636. doi: 10.1016/j.jaad.2021.06.017</mixed-citation><mixed-citation xml:lang="ru">Narla S., Silverberg J.I., Simpson E.L. Management of inadequate response and adverse effects to dupilumab in atopic dermatitis // J Am acad Dermatol. 2022. Vol. 86, N 3. Р. 628–636. doi: 10.1016/j.jaad.2021.06.017</mixed-citation></citation-alternatives></ref><ref id="B53"><label>53.</label><citation-alternatives><mixed-citation xml:lang="en">Howe W. Treatment of atopic dermatitis (eczema) ― UpToDate. Last updated: Mar 11, 2022. Available from: https://www.uptodate.com/contents/treatment-of-atopic-dermatitis-eczema/print?sectionName=Frequency%20of%20bathing&amp;search=ambulatory-&amp;topicRef=8349&amp;anchor=H3882190426&amp;source=see_link. Accessed: 15.04.2022.</mixed-citation><mixed-citation xml:lang="ru">Howe W. Treatment of atopic dermatitis (eczema) ― UpToDate. Last updated: Mar 11, 2022. Режим доступа: https://www.uptodate.com/contents/treatment-of-atopic-dermatitis-eczema/print?sectionName=Frequency%20of%20bathing&amp;search=ambulatory-&amp;topicRef=8349&amp;anchor=H3882190426&amp;source=see_link. Дата обращения: 15.04.2022.</mixed-citation></citation-alternatives></ref><ref id="B54"><label>54.</label><citation-alternatives><mixed-citation xml:lang="en">Cartron AM, Nguyen TH, Roh YS, et al. Janus kinase inhibitors for atopic dermatitis: a promising treatment modality. Clin Exp Dermatol. 2021;46(5):820–824. doi: 10.1111/ced.14567</mixed-citation><mixed-citation xml:lang="ru">Cartron A.M., Nguyen T.H., Roh Y.S., et al. Janus kinase inhibitors for atopic dermatitis: a promising treatment modality. Clin Exp Dermatol. 2021. Vol. 46, N 5. Р. 820–824. doi: 10.1111/ced.14567</mixed-citation></citation-alternatives></ref><ref id="B55"><label>55.</label><citation-alternatives><mixed-citation xml:lang="en">Traidl S, Freimooser S, Werfel T. Janus kinase inhibitors for the therapy of atopic dermatitis. Allergologie Select. 2021;5:293–304. doi: 10.5414/ALX02272E</mixed-citation><mixed-citation xml:lang="ru">Traidl S., Freimooser S., Werfel T. Janus kinase inhibitors for the therapy of atopic dermatitis // Allergologie Select. 2021. Vol. 5. Р. 293–304. doi: 10.5414/ALX02272E</mixed-citation></citation-alternatives></ref><ref id="B56"><label>56.</label><citation-alternatives><mixed-citation xml:lang="en">Silverberg JI, Thyssen JP, Fahrbach K, et al. Comparative efficacy and safety of systemic therapies used in moderate-to-severe atopic dermatitis: a systematic literature review and network meta-analysis. J Eur Acad Dermatol Venereol. 2021;35(9):1797–1810. doi: 10.1111/jdv.17351</mixed-citation><mixed-citation xml:lang="ru">Silverberg J.I., Thyssen J.P., Fahrbach K., et al. Comparative efficacy and safety of systemic therapies used in moderate-to-severe atopic dermatitis: a systematic literature review and network meta-analysis // J Eur Acad Dermatol Venereol. 2021. Vol. 35, N 9. Р. 1797–1810. doi: 10.1111/jdv.17351</mixed-citation></citation-alternatives></ref><ref id="B57"><label>57.</label><citation-alternatives><mixed-citation xml:lang="en">Pereyra-Rodriguez JJ, Alcantara-Luna S, Domínguez-Cruz J, et al. Short-term effectiveness and safety of biologics and small molecule drugs for moderate to severe atopic dermatitis: a systematic review and network meta-analysis. Life (Basel). 2021;11(9):927. doi: 10.3390/life11090927</mixed-citation><mixed-citation xml:lang="ru">Pereyra-Rodriguez J.J., Alcantara-Luna S., Domínguez-Cruz J., et al. Short-term effectiveness and safety of biologics and small molecule drugs for moderate to severe atopic dermatitis: a systematic review and network meta-analysis // Life (Basel). 2021. Vol. 11, N 9. Р. 927. doi: 10.3390/life11090927</mixed-citation></citation-alternatives></ref><ref id="B58"><label>58.</label><citation-alternatives><mixed-citation xml:lang="en">Silverberg JI, Hong HC, Thyssen JP, et al. Comparative efficacy of targeted systemic therapies for moderate to severe atopic dermatitis without topical corticosteroids: systematic review and network meta-analysis. Dermatol Ther (Heidelb). 2022;12(5):1181–1196. doi: 10.1007/s13555-022-00721-1</mixed-citation><mixed-citation xml:lang="ru">Silverberg J.I., Hong H.C., Thyssen, J.P., et al. Comparative efficacy of targeted systemic therapies for moderate to severe atopic dermatitis without topical corticosteroids: systematic review and network meta-analysis // Dermatol Ther (Heidelb). 2022. Vol. 12, N 5. Р. 1181–1196. doi: 10.1007/s13555-022-00721-1</mixed-citation></citation-alternatives></ref><ref id="B59"><label>59.</label><citation-alternatives><mixed-citation xml:lang="en">Parmentier JM, Voss J, Graff C, et al. In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494). BMC Rheumatol. 2018;(2):23. doi: 10.1186/s41927-018-0031-x</mixed-citation><mixed-citation xml:lang="ru">Parmentier J.M., Voss J., Graff C., et al. In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494) // BMC Rheumatol. 2018. N 2. Р. 23. doi: 10.1186/s41927-018-0031-x</mixed-citation></citation-alternatives></ref><ref id="B60"><label>60.</label><citation-alternatives><mixed-citation xml:lang="en">Traves PG, Murray B, Campigotto F, et al. JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib. Ann Rheum Dis. 2021;80(7):865–875. doi: 10.1136/annrheumdis-2020-219012</mixed-citation><mixed-citation xml:lang="ru">Traves P.G., Murray B., Campigotto F., et al. JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib // Ann Rheum Dis. 2021. Vol. 80, N 7. Р. 865–875. doi: 10.1136/annrheumdis-2020-219012</mixed-citation></citation-alternatives></ref><ref id="B61"><label>61.</label><citation-alternatives><mixed-citation xml:lang="en">McInnes IB, Byers NL, Higgs RE, et al. Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations. Arthritis Res Ther. 2019;21(1):183. doi: 10.1186/s13075-019-1964-1</mixed-citation><mixed-citation xml:lang="ru">McInnes I.B., Byers N.L., Higgs R.E., et al. Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations // Arthritis Res Ther. 2019. Vol. 21, N 1. Р. 183. doi: 10.1186/s13075-019-1964-1</mixed-citation></citation-alternatives></ref><ref id="B62"><label>62.</label><citation-alternatives><mixed-citation xml:lang="en">Guttman-Yassky E, Teixeira HD, Simpson EL, et al. Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials. Lancet. 2021;397(10290):2151–2168. doi: 10.1016/S0140-6736(21)00588-2</mixed-citation><mixed-citation xml:lang="ru">Guttman-Yassky E., Teixeira H.D., Simpson E.L., et al. Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials // Lancet. 2021. Vol. 397, N 10290. Р. 2151–2168. doi: 10.1016/S0140-6736(21)00588-2</mixed-citation></citation-alternatives></ref><ref id="B63"><label>63.</label><citation-alternatives><mixed-citation xml:lang="en">Reich K, Teixeira HD, de Bruin-Weller M, et al. Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2021;397(10290):2169–2181. doi: 10.1016/S0140-6736(21)00589-4</mixed-citation><mixed-citation xml:lang="ru">Reich K., Teixeira H.D., de Bruin-Weller M., et al. Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from a randomised, double-blind, placebo-controlled, phase 3 trial // Lancet. 2021. Vol. 397, N 10290. Р. 2169–2181. doi: 10.1016/S0140-6736(21)00589-4</mixed-citation></citation-alternatives></ref><ref id="B64"><label>64.</label><citation-alternatives><mixed-citation xml:lang="en">Paller AS, Mendes-Bastos P, Eichenfield LF, et al. Efficacy and safety of upadacitinib in adults and adolescents with moderate-to-severe atopic dermatitis: A subgroup analysis of the Measure Up 1, Measure Up 2 and AD Up phase III clinical trials. Br J Dermatol. 2021;185(3):e128–e129.</mixed-citation><mixed-citation xml:lang="ru">Paller A.S., Mendes-Bastos P., Eichenfield L.F., et al. Efficacy and safety of upadacitinib in adults and adolescents with moderate-to-severe atopic dermatitis: a subgroup analysis of the Measure Up 1, Measure Up 2 and AD Up phase III clinical trials // Br J Dermatol. 2021. Vol. 185, N 3. Р. e128–e129.</mixed-citation></citation-alternatives></ref><ref id="B65"><label>65.</label><citation-alternatives><mixed-citation xml:lang="en">Guttman-Yassky E, Teixeira HD, Simpson EL, et al. Safety and efficacy of upadacitinib monotherapy in adolescents and adults with moderate-to-severe atopic dermatitis: results from 2 pivotal, phase 3, randomized, double-blinded, monotherapy, placebo-controlled studies (Measure Up 1 and Measure Up 2). European Academy Dermatology Venerology Congress; 2020. D3T03.4B.</mixed-citation><mixed-citation xml:lang="ru">Guttman-Yassky E., Teixeira H.D., Simpson E.L., et al. Safety and efficacy of upadacitinib monotherapy in adolescents and adults with moderate-to-severe atopic dermatitis: results from 2 pivotal, phase 3, randomized, double-blinded, monotherapy, placebo-controlled studies (Measure Up 1 and Measure Up 2) // Eur Academy Dermatol Venerol Congress. 2020. D3T03.4B.</mixed-citation></citation-alternatives></ref><ref id="B66"><label>66.</label><citation-alternatives><mixed-citation xml:lang="en">Guttman-Yassky E, Teixeira HD, Simpson EL, et al. Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials. Lancet. 2021;397(10290):2151–2168. doi: 10.1016/S0140-6736(21)00588-2</mixed-citation><mixed-citation xml:lang="ru">Guttman-Yassky E., Teixeira H.D., Simpson E.L., et al. Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials // Lancet. 2021. Vol. 397, N 10290. Р. 2151–2168. doi: 10.1016/S0140-6736(21)00588-2</mixed-citation></citation-alternatives></ref><ref id="B67"><label>67.</label><citation-alternatives><mixed-citation xml:lang="en">Ardern-Jones MR, Beck L, Calimlim B, et al. Rapid symptom and sleep improvement with upadacitinib with or without topical corticosteroids (TCS) in moderate-to-severe atopic dermatitis: results from 3 phase 3 studies (Measure Up 1, Measure Up 2, and AD Up) ISAD 2021 (PE-21), Abstract from 11th George Rajka International Symposium on Atopic Dermatitis April 19–20, Korea. Seoul; 2021. P. 34.</mixed-citation><mixed-citation xml:lang="ru">Ardern-Jones M.R., Beck L., Calimlim B., et al. Rapid symptom and sleep improvement with upadacitinib with or without topical corticosteroids (TCS) in moderate-to-severe atopic dermatitis: results from 3 phase 3 studies (Measure Up 1, Measure Up 2, and AD Up) ISAD 2021 (PE-21), Abstract from 11th George Rajka International Symposium on Atopic Dermatitis April 19–20, Korea. Seoul, 2021. Р. 34.</mixed-citation></citation-alternatives></ref><ref id="B68"><label>68.</label><citation-alternatives><mixed-citation xml:lang="en">Eyerich K, Lynde CW, Calimlim B, et al. Rapid quality-of-life improvement with upadacitinib with or without topical corticosteroids (TCS) in moderate-tosevere atopic dermatitis: results from 3 phase 3 studies (Measure Up 1, Measure Up 2, and AD Up) ISAD 2021 (PE-20), Abstract from 11th George Rajka International Symposium on Atopic Dermatitis April 19–20, Korea. Seoul; 2021. P. 34–35.</mixed-citation><mixed-citation xml:lang="ru">Eyerich K., Lynde C.W., Calimlim B., et al. Rapid quality-of-life improvement with upadacitinib with or without topical corticosteroids (TCS) in moderate-tosevere atopic dermatitis: results from 3 phase 3 studies (Measure Up 1, Measure Up 2, and AD Up) ISAD 2021 (PE-20), Abstract from 11th George Rajka International Symposium on Atopic Dermatitis April 19–20, Korea. Seoul, 2021. P. 34–35.</mixed-citation></citation-alternatives></ref><ref id="B69"><label>69.</label><citation-alternatives><mixed-citation xml:lang="en">Reich K, de Bruin-Weller MS, Deleuran M, et al. Eczema activity and severity index (EASI) and validated investigator global assessment of atopic dermatitis (VIGA-AD) response are associated with improvements in other outcome measures: an analysis of 3 phase 3 trials of upadacitinib in patients with moderate-to-severe atopic dermatitis, ISAD 2021 (PE-19) Abstract from 11th George Rajka International Symposium on Atopic Dermatitis April 19–20, Korea. Seoul; 2021. P. 34.</mixed-citation><mixed-citation xml:lang="ru">Reich K., de Bruin-Weller M.S., Deleuran M., et al. Eczema activity and severity index (EASI) and validated investigator global assessment of atopic dermatitis (VIGA-AD) response are associated with improvements in other outcome measures: an analysis of 3 phase 3 trials of upadacitinib in patients with moderate-to-severe atopic dermatitis, ISAD 2021 (PE-19) Abstract from 11th George Rajka International Symposium on Atopic Dermatitis April 19–20, Korea. Seoul, 2021. P. 34.</mixed-citation></citation-alternatives></ref><ref id="B70"><label>70.</label><citation-alternatives><mixed-citation xml:lang="en">Blauvelt A, Teixeira HD, Simpson EL, et al. Efficacy and safety of upadacitinib vs dupilumab in adults with moderate-to-severe atopic dermatitis: a randomized clinical trial. JAMA Dermatol. 2021; 157(9):1047–1055. doi: 10.1001/jamadermatol.2021.3023</mixed-citation><mixed-citation xml:lang="ru">Blauvelt A., Teixeira H.D., Simpson E.L., et al. Efficacy and safety of upadacitinib vs dupilumab in adults with moderate-to-severe atopic dermatitis: a randomized clinical trial // JAMA Dermatol. 2021. Vol. 157, N 9. Р. 1047–1055. doi: 10.1001/jamadermatol.2021.3023</mixed-citation></citation-alternatives></ref><ref id="B71"><label>71.</label><citation-alternatives><mixed-citation xml:lang="en">Simpson EL, Papp KA, Blauvelt A, et al. Efficacy and safety of upadacitinib in patients with moderate to severe atopic dermatitis: analysis of follow-up data from the Measure Up 1 and Measure Up 2 randomized clinical trials. JAMA Dermatol. 2022;158(4):404–413. doi: 10.1001/jamadermatol.2022.0029</mixed-citation><mixed-citation xml:lang="ru">Simpson E.L., Papp K.A., Blauvelt A., et al. Efficacy and safety of upadacitinib in patients with moderate to severe atopic dermatitis: analysis of follow-up data from the Measure Up 1 and Measure Up 2 randomized clinical trials // JAMA Dermatol. 2022. Vol. 158, N 4. Р. 404–413. doi: 10.1001/jamadermatol.2022.0029</mixed-citation></citation-alternatives></ref><ref id="B72"><label>72.</label><citation-alternatives><mixed-citation xml:lang="en">Silverberg JI, de Bruin-Weller M, Bieber T, et al. Upadacitinib plus topical corticosteroids in atopic dermatitis: week 52 AD Up study results. J Allergy Clin Immunol. 2022;149(3):977–987.e14. doi: 10.1016/j.jaci.2021.07.036</mixed-citation><mixed-citation xml:lang="ru">Silverberg J.I., de Bruin-Weller M., Bieber T., et al. Upadacitinib plus topical corticosteroids in atopic dermatitis: week 52 AD Up study results // J Allergy Clin Immunol. 2022. Vol. 149, N 3. Р. 977–987.e14. doi: 10.1016/j.jaci.2021.07.036</mixed-citation></citation-alternatives></ref></ref-list></back></article>
