Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press151110.36691/RJA1511ReviewsНаучные обзорыReview ArticleThe effect of exposome factors on the functions of filaggrin functions in atopic dermatitisВлияние некоторых экспосомных факторов на функции филаггрина при атопическом дерматитеhttps://orcid.org/0000-0001-5999-70852399-5783MacharadzeDali Sh.МачарадзеДали Шотаевна
Russian Federation

MD, Dr. Sci (Med.)

д.м.н.

dalim_a@mail.ruPeoples’ Friendship University of RussiaРоссийский университет дружбы народов24052022060620221922342440501202225042022Copyright ©; 2022, Pharmarus Print MediaCopyright ©; 2022, Фармарус Принт Медиа2022Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/1511

Atopic dermatitis is a heterogeneous inflammatory skin disease, which is affected by many internal (genetic) and external factors. The interaction between genetic and environmental factors is a complex dynamic process. These factors affect each other and can be interrelated.

This article discusses data on filaggrin and some exposome factors affecting it.

The term “exposome” refers to the impact of external factors on the biological environment of the body. The impact range is varied and includes chemicals, psychosocial and physical factors, as well as associated biological reactions that occur throughout human life.

The article examines the link between filaggrin mutations and genetic predisposition, as well as how the defects of the skin barrier, immunological imbalance, and a variety of stimuli have a potential impact. The mechanisms of action of various factors on filaggrin in atopic dermatitis are also considered. Furthermore, environmental factors can influence the expression of various genes and, as a result, create epigenetic changes in patients with atopic dermatitis.

The study of epigenetic changes is critical for understanding the molecular bases of this skin disease and optimizing treatment strategies.

Атопический дерматит ― гетерогенное воспалительное заболевание кожи, на которое влияет множество внутренних (генетических) и внешних факторов. Взаимодействие между генетическими и факторами окружающей среды является сложным динамичным процессом. Эти факторы влияют друг на друга и могут быть взаимосвязанными.

В обзоре рассматриваются данные о филаггрине и некоторых экспосомных факторах, влияющих на него.

Термин «экспосом» включает в себя понятие о влиянии внешних факторов на биологическую среду организма, диапазон которых достаточно разнообразен ― от воздействия химических веществ, психосоциальных и физических факторов до связанных с ними биологических реакций на протяжении всей жизни человека.

В статье обсуждается связь генетической предрасположенности и мутаций филаггрина, на которые потенциальное влияние оказывают дефекты кожного барьера, иммунный дисбаланс и разнообразные триггеры.

Рассматриваются также механизмы действия различных экспосомных факторов на филаггрин при атопическом дерматите. Кроме того, факторы окружающей среды могут влиять на экспрессию различных генов и, соответственно, быть причиной эпигенетических изменений у больных атопическим дерматитом.

Изучение эпигенетических изменений имеет важное значение для уточнения молекулярных основ этого кожного заболевания и улучшения методов его терапии.

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