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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="letter" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1482</article-id><article-id pub-id-type="doi">10.36691/RJA1482</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Letters to the editor</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Письма в редакцию</subject></subj-group><subj-group subj-group-type="article-type"><subject>Correspondence</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Pediatric anaphylaxis: unresolved issues of diagnosis and patient management</article-title><trans-title-group xml:lang="ru"><trans-title>Анафилаксия в педиатрической практике: нерешённые вопросы диагностики и ведения пациентов</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5039-8473</contrib-id><contrib-id contrib-id-type="spin">9722-7961</contrib-id><name-alternatives><name xml:lang="en"><surname>Pampura</surname><given-names>Alexander N.</given-names></name><name xml:lang="ru"><surname>Пампура</surname><given-names>Александр Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д.м.н.</p></bio><email>apampura@pedklin.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8792-2670</contrib-id><contrib-id contrib-id-type="spin">6924-9726</contrib-id><name-alternatives><name xml:lang="en"><surname>Esakova</surname><given-names>Natalia V.</given-names></name><name xml:lang="ru"><surname>Есакова</surname><given-names>Наталья Владиславовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>env007@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский клинический институт педиатрии имени академика Ю.Е. Вельтищева ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова»</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2021-09-14" publication-format="electronic"><day>14</day><month>09</month><year>2021</year></pub-date><pub-date date-type="pub" iso-8601-date="2021-10-06" publication-format="electronic"><day>06</day><month>10</month><year>2021</year></pub-date><volume>18</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>131</fpage><lpage>136</lpage><history><date date-type="received" iso-8601-date="2021-09-10"><day>10</day><month>09</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-09-10"><day>10</day><month>09</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, Фармарус Принт Медиа</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2023-10-06"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/1482">https://rusalljournal.ru/raj/article/view/1482</self-uri><abstract xml:lang="en"><p>The incidence of anaphylaxis is increasing in children. Children suffering from anaphylaxis represent a complex and ambiguous group of patients. The factors that cause difficulties in diagnosing anaphylaxis in children are as follows: a wide range of triggers, unpredictability of the nature, severity of clinical symptoms of systemic reactions, and their age-dependent interpretation. The first anaphylactic reaction always stuns parents and medical staff, which leads to a subjective description of the anamnesis and a delay in making a diagnosis and prescribing the correct treatment. For these patients, problems such as the lack of available diagnostic tests for verifying the diagnosis of anaphylaxis, restriction of standard doses of epinephrine autoinjectors, lack of predictors of the occurrence, and severity of systemic allergic reactions continue to be relevant.</p> <p>The article focused on the most urgent difficulties and features of managing patients with anaphylaxis in pediatric practice and discussed possible prospects and ways to solve them.</p></abstract><trans-abstract xml:lang="ru"><p>В последние годы повсеместно прослеживается тенденция роста заболеваемости анафилаксией среди детей. Вместе с тем дети, страдающие анафилаксией, представляют сложную и неоднозначную группу пациентов. Среди факторов, осложняющих диагностику анафилаксии у детей, можно отметить достаточно широкий спектр триггеров, непредсказуемость характера, тяжесть клинических симптомов системных реакций и особенности их интерпретации в зависимости от возраста ребёнка. Первая анафилактическая реакция, практически всегда ошеломляющая как для родителей, так и медицинского персонала, зачастую приводит к крайне субъективному изложению анамнеза и, как следствие, несвоевременной постановке диагноза и неадекватной терапии. Кроме того, в данной группе пациентов продолжают оставаться актуальными такие проблемы, как отсутствие доступных диагностических тестов для верификации диагноза анафилаксии, ограничение стандартных доз аутоинъекторов эпинефрина, отсутствие предикторов возникновения и тяжести системных аллергических реакций.</p> <p>В статье представлены наиболее актуальные проблемы диагностики анафилаксии и особенности ведения педиатрических пациентов, обсуждаются возможные перспективы и пути их решения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>anaphylaxis</kwd><kwd>anaphylactic reaction</kwd><kwd>trigger</kwd><kwd>allergen</kwd><kwd>children</kwd><kwd>food allergy</kwd><kwd>infants</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>анафилаксия</kwd><kwd>анафилактическая реакция</kwd><kwd>триггер</kwd><kwd>аллерген</kwd><kwd>дети</kwd><kwd>пищевая аллергия</kwd><kwd>младенцы</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Lin RY, Anderson AS, Shah SN, Nurruzzaman F. 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