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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1369</article-id><article-id pub-id-type="doi">10.36691/RJA1369</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">A case of atopic dermatitis with a severe resistant course in adult patient with atopic march</article-title><trans-title-group xml:lang="ru"><trans-title>Случай атопического дерматита с тяжелым резистентным к лечению течением у взрослого пациента с атопическим маршем</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6371-9176</contrib-id><name-alternatives><name xml:lang="en"><surname>Tusupbekova</surname><given-names>Galiya M.</given-names></name><name xml:lang="ru"><surname>Тусупбекова</surname><given-names>Галия Марксовна</given-names></name></name-alternatives><address><country country="KZ">Kazakhstan</country></address><bio xml:lang="en"><p>Head of the Allergy service and the Center of Allergy</p></bio><bio xml:lang="ru"><p>руководитель аллергологической службы и Центра аллергологии</p></bio><email>Galiya.tgm@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3300-684X</contrib-id><name-alternatives><name xml:lang="en"><surname>Syzdykova</surname><given-names>Aigul A.</given-names></name><name xml:lang="ru"><surname>Сыздыкова</surname><given-names>Айгуль Амангельдыевна</given-names></name></name-alternatives><address><country country="KZ">Kazakhstan</country></address><bio xml:lang="en"><p>allergologist-immunologist</p></bio><bio xml:lang="ru"><p>врач аллерголог-иммунолог</p></bio><email>aigul18_04@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4505-9319</contrib-id><name-alternatives><name xml:lang="en"><surname>Davletova</surname><given-names>Botagoz M.</given-names></name><name xml:lang="ru"><surname>Давлетова</surname><given-names>Ботагоз Маликовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>allergologist-immunologist</p></bio><bio xml:lang="ru"><p>врач аллерголог-иммунолог</p></bio><email>botashadavletova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan</institution></aff><aff><institution xml:lang="ru">РГП «Больница Медицинского центра Управления делами Президента Республики Казахстан»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-07-23" publication-format="electronic"><day>23</day><month>07</month><year>2020</year></pub-date><volume>17</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>69</fpage><lpage>73</lpage><history><date date-type="received" iso-8601-date="2020-07-03"><day>03</day><month>07</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2020-07-03"><day>03</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, Фармарус Принт Медиа</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2022-07-23"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/1369">https://rusalljournal.ru/raj/article/view/1369</self-uri><abstract xml:lang="en"><p><bold><underline>Introduction.</underline></bold> The atopic march is the natural course of development of atopy symptoms. It is characterized by a typical sequence of development of clinical symptoms of atopic disease, when some symptoms become more significant, others are recede. Timely allergological diagnostics with the identification of causal allergens allows to preventor suspend the atopic march.</p> <p>Purpose of the study was to demonstrate the stages of the atopic march formation and clinical manifestations of atopy, the importance of on timely detection of causal allergens, the capability of modern diagnostics and treatment of severe resistant forms of allergic diseases.</p> <p> </p><p> </p> </abstract><trans-abstract xml:lang="ru"><p><bold><underline>Введение.</underline></bold> Атопический марш является естественным ходом развития проявлений атопии. Он характеризуется типичной последовательностью развития клинических симптомов атопической болезни, когда одни симптомы становятся более выраженными, другие идут на убыль. Своевременное проведение аллергологической диагностики с выявлением причинно-значимых аллергенов позволяет не допустить возникновения атопического марша или приостановить его развитие.</p> <p><bold><underline>Цель</underline>.</bold> Продемонстрировать этапы формирования атопического марша и клинических проявлений атопии, важность своевременного выявления причинно-значимых аллергенов, возможности современной диагностики и лечения тяжелых резистентных форм аллергических заболеваний.</p></trans-abstract><kwd-group xml:lang="en"><kwd>atopic march</kwd><kwd>atopic dermatitis</kwd><kwd>heredity</kwd><kwd>polysensitization</kwd><kwd>molecular diagnostic</kwd><kwd>biologic therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>атопический дерматит</kwd><kwd>атопический марш</kwd><kwd>наследственность</kwd><kwd>полисенсибилизация</kwd><kwd>молекулярная диагностика</kwd><kwd>биологическая терапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Czarnowicki T, Krueger JG, Guttman-Yassky E. 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