Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press135910.36691/RJA1359LectionsЛекцииResearch ArticleFresh look on the urticaria problem.Новый взгляд на проблему крапивницы.https://orcid.org/0000-0002-5021-9276LitovkinaAlla O.ЛитовкинаАлла Олеговна
Russian Federation

graduate student in Department of Skin Allergy and Immunopathology

аспирант отделения аллергологии и иммунопатологии кожи

dr.litovkina@gmail.comhttps://orcid.org/0000-0003-1302-4178SmolnikovEugenii V.СмольниковЕвгений Валентинович
Russian Federation

graduate student in Department of Skin Allergy and Immunopathology

аспирант отделения аллергологии и иммунопатологии кожи

qwertil2010@yandex.ruhttps://orcid.org/0000-0002-4609-2591ElisyutinaOlga G.ЕлисютинаОльга Гурьевна
Russian Federation

MD, PhD, DSc, leading researcher of the Department of Skin allergy and immunopathology

доктор медицинских наук, в.н.с.

el-olga@yandex.ruhttps://orcid.org/0000-0003-3358-50876603386923P-6912-20155012-7242FedenkoElena S.ФеденкоЕлена Сергеевна
Russian Federation

MD, PhD, DSc, professor, head of the Department of Skin allergy and immunopathology

доктор медицинских наук, профессор, зав. отделением аллергологии и иммунопатологии кожи

efedks@gmail.comNRC Institute of Immunology FMBA of RussiaФГБУ «ГНЦ Институт иммунологии» ФМБА РоссииNRCI Institute of Immunology FMBA of RussiaФГБУ «ГНЦ Институт иммунологии» ФМБА РоссииNRS Institute of Immunology FMBA of RussiaФГБУ «ГНЦ «Институт Иммунологии» ФМБА России2307202017233432305202008062020Copyright ©; 2020, Pharmarus Print MediaCopyright ©; 2020, Фармарус Принт Медиа2020Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/1359

Introduction. Nowadays urticaria is one of the most common diseases. According to the International Guidelines for the definition, classification, diagnosis and management of urticaria, 2nd-generation H1-antihistamines are recommended to be used as the first-line and second-line therapy. Omalizumab, a humanized monoclonal anti-IgE antibody, is assumed to be the third-line therapy in urticaria treatment.

Summary. In this review we discuss the latest data on pathogenetic mechanisms of urticaria, focusing on the search of the new targets for the therapy. We represent the latest clinical trials of the new biological treatment for urticaria. Safety and efficiency of 4-folds higher therapeutical dose of the 2nd generation H1-antihistamines, and criteria for personalized selection of the antihistamines are discussed.

Введение. Крапивница является одним из наиболее часто встречающихся заболеваний. Согласно международным рекомендациям, терапией первой и второй линии крапивницы являются H1-антигистаминные препараты 2-го поколения, терапией третьей линии – моноклональное антитело к IgE – омализумаб.

Основная часть. В обзоре обсуждаются патогенетические механизмы крапивницы с позиции поиска новых мишеней для разработки таргетной терапии. Приводятся данные о клинических испытаниях новых биологических препаратов для лечения крапивницы. Представлены данные о безопасности и эффективности применения антигистаминных препаратов второго поколения в четырехкратной дозировке, а также критерии, важные для индивидуального подбора препарата.

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