Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press134510.36691/RAJ.2020.17.1.002ArticlesСтатьиReview ArticleDrug-induced anaphylaxis: prevalence, risk factors, triggersЛекарственная анафилаксия: распространенность, факторы риска, триггерыEsakovaNatalia VЕсаковаНаталья Владиславовна

к.м.н., научный сотрудник отдела аллергологии и клинической иммунологии

env007@rambler.ruPampuraAlexander NikolaevichПампураАлександр Николаевич

доктор медицинских наук, зав. отделом аллергологии и клинической иммунологии

Academician Yu.E. Veltishchev Research Clinical Institute of Pediatrics N.I. Pirogov Russian National Research Medical UniversityОСП «Научно-исследовательский клинический институт педиатрии имени академика Ю.Е. Вельтищева» ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России15022020171VOL 17, NO1 (2020)ТОМ 17, №1 (2020)233102042020Copyright ©; 2020, Pharmarus Print MediaCopyright ©; 2020, Фармарус Принт Медиа2020Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/1345

Currently, there is a tendency to increase the prevalence of drug-induced anaphylaxis. Medicines occupy a leading position among the causes of the development of anaphylactic reactions in the adult group of patients and second place in children, the most significant in this matter are non-steroidal anti-inflammatory drugs, antibacterial drugs and X-ray contrast agents. The risk of developing of drug anaphylaxis in most cases is not predictable, while the frequency of severe and fatal reactions is extremely high. This article presents an analysis of current data regarding the prevalence, possible risk factors, and triggers of drug anaphylaxis.

Повсеместное увеличение частоты анафилаксии в целом сопровождается тенденцией к повышению распространенности и лекарственной анафилаксии. Лекарственные препараты занимают лидирующую позицию среди причин развития анафилактических реакций у взрослой группы пациентов и второе место у детей. При этом наиболее значимыми являются нестероидные противовоспалительные средства, антибактериальные препараты и рентгеноконтрастные вещества. Риск развития лекарственной анафилаксии в большинстве случаев непредсказуем, причем частота тяжелых и летальных реакций крайне высока. В настоящей статье представлен анализ современных данных о распространенности, возможных факторах риска и триггерах лекарственной анафилаксии.

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