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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">128</article-id><article-id pub-id-type="doi">10.36691/RJA128</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Cross-sectional study of allergen sensitization in pre-school children living in urban environment of the Altai region with asthma and/or rhinitis</article-title><trans-title-group xml:lang="ru"><trans-title>Одномоментное исследование спектра сенсибилизации у детей дошкольного возраста с бронхиальной астмой и аллергическим ринитом, проживающих в городских условиях Алтайского края</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shakhova</surname><given-names>N V</given-names></name><name xml:lang="ru"><surname>Шахова</surname><given-names>Наталья Викторовна</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, доцент кафедры пропедевтики детских болезней, врач аллерголог-иммунолог</p></bio><email>natalia.shakhova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kamaltynova</surname><given-names>E M</given-names></name><name xml:lang="ru"><surname>Камалтынова</surname><given-names>Елена Михайловна</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, доцент кафедры факультетской педиатрии с курсом детских болезней лечебного факультета</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lobanov</surname><given-names>Y Ph</given-names></name><name xml:lang="ru"><surname>Лобанов</surname><given-names>Юрий Федорович</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, зав. кафедрой пропедевтики детских болезней</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kashinskaya</surname><given-names>T S</given-names></name><name xml:lang="ru"><surname>Кашинская</surname><given-names>Татьяна Сергеевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры пропедевтики детских болезней</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Altai State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Алтайский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Siberian State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2018</year></pub-date><volume>15</volume><issue>5</issue><issue-title xml:lang="en">NO5 (2018)</issue-title><issue-title xml:lang="ru">№5 (2018)</issue-title><fpage>76</fpage><lpage>80</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Фармарус Принт Медиа</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2020-12-15"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/128">https://rusalljournal.ru/raj/article/view/128</self-uri><abstract xml:lang="en"><p>Sensitization spectrum in pre-school children with asthma and/or rhinitis remains unclear. Objective. Our aim was to estimate the allergen sensitization in preschool children living in urban environment of the Altai region with asthma and/or rhinitis. Materials and methods. A cross-sectional survey was performed in 182 children aged from 3 to 6 years suffering from asthma and/or rhinitis in 5 cities of Altai region. Asthma was diagnosed according to the Global Initiative for Asthma guidelines, allergic rhinitis was diagnosed according to the ARIA guidelines. ImmunoCAP and skin prick test were used to assess sensitization spectrum. Results. Among the 182 patients 144 (79,1%) had sensitization at least to one allergen. Sensitization to one allergen was detected in 38.5% of children, sensitization to 2 or more allergens - in 40,6%. Sensitization to Dermatophagoides pteronyssinus was detected in 46,7%, to birch pollen - in 37,3%, to cat epithelium - in 27,4% of patients. Sensitization to food allergens was detected only in 10,4%. Conclusion. The study revealed a high frequency of sensitization to 2 or more allergens - in 79,1% of 3-6 years old children with asthma and/or rhinitis . Most often, preschool children with asthma and/or rhinitis are sensitized to 3 inhaled allergens - to Dermatophagoides pteronyssinus (46,7%), to birch pollen (37,3%) and to cat epithelium (27,4%).</p></abstract><trans-abstract xml:lang="ru"><p>Цель. Изучить спектр сенсибилизации у детей 3-6 лет с бронхиальной астмой (БА) и аллергическим ринитом (АР), проживающих в городских условиях Алтайского края. Материалы и методы. Проведено одномоментное исследование спектра сенсибилизации у 182 детей 3-6 лет с БА и АР, проживающих в 5 крупных городах Алтайского края. Критерии диагностики БА - GINA (updated 2018), критерии диагностики АР - ARIA (2008). Аллергологическое обследование: кожное прик-тестирование с 8 стандартизованными экстрактами аллергенов Allergopharma (Германия), или определение аллерген-специфических IgE методом иммунофлуоресценции на автоматическом анализаторе Phadia ImmunoCAP 250. Результаты. Сенсибилизация выявлена у 79,1% детей с БА и АР. Сенсибилизация к одному аллергену выявлена 38,5% детей, сенсибилизация к 2 и более аллергенам - у 40,6%. Наиболее часто выявлялась сенсибилизация к клещу домашней пыли Dermatophagoides pteronyssinus - 46,7%, пыльце березы - 37,3% и эпителию кошки - 27,4%. Сенсибилизация к пищевым аллергенам выявлена лишь у 10,4%. Заключение. Исследование выявило высокую частоту сенсибилизации (79,1%) среди детей 3-6 лет с БА и АР, при этом более половины сенсибилизированы к 2 и более аллергенам. Наиболее часто дети дошкольного возраста с БА и АР сенсибилизированы к 3 ингаляционным аллергенам - к клещу домашней пыли Dermatophagoides pteronyssinus (46,7%), к пыльце березы (37,3%) и эпителию кошки (27,4%).</p></trans-abstract><kwd-group xml:lang="en"><kwd>allergic rhinitis</kwd><kwd>bronchial asthma</kwd><kwd>sensitization</kwd><kwd>children</kwd><kwd>polysensitization</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аллергический ринит</kwd><kwd>бронхиальная астма</kwd><kwd>сенсибилизация</kwd><kwd>дети</kwd><kwd>полисенсибилизация</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Pearce N, Aït-Khaled N, Beasley R. Mallol J, Keil U, Mitchell E et al. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax. 2007;62:758-766. 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