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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">122</article-id><article-id pub-id-type="doi">10.36691/RJA122</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Exercise induced bronchoconstriction in elite athletes</article-title><trans-title-group xml:lang="ru"><trans-title>Бронхиальная обструкция в спорте высших достижений</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tsarev</surname><given-names>S V</given-names></name><name xml:lang="ru"><surname>Царев</surname><given-names>Сергей Владимирович</given-names></name></name-alternatives><email>sw-tsarev@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ilina</surname><given-names>N I</given-names></name><name xml:lang="ru"><surname>Ильина</surname><given-names>Наталья Ивановна</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, зам. директора по клинической работе, главный врач</p></bio><email>instummun@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khaitov</surname><given-names>M R</given-names></name><name xml:lang="ru"><surname>Хаитов</surname><given-names>Муса Рахимович</given-names></name></name-alternatives><bio xml:lang="ru"><p>директор, доктор медицинских наук, профессор, член-корреспондент РАН</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">NRC Institute of Immunology FMBA of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «ГНЦ Институт иммунологии» ФМБА России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2018</year></pub-date><volume>15</volume><issue>5</issue><issue-title xml:lang="en">NO5 (2018)</issue-title><issue-title xml:lang="ru">№5 (2018)</issue-title><fpage>17</fpage><lpage>28</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Фармарус Принт Медиа</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2020-12-15"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/122">https://rusalljournal.ru/raj/article/view/122</self-uri><abstract xml:lang="en"><p>The problem of exerciseinduced airway hyper responsiveness and bronchial obstruction is discussed in the review. Epidemiological data on the prevalence of bronchial obstruction in elite athletes of various sports are presented. Modern concepts of etiological and trigger factors caused by exercise induced bronchospasm are considered. Pathogenetic aspects of the formation of bronchial obstruction in athletes are presented.</p></abstract><trans-abstract xml:lang="ru"><p>В статье обсуждается проблема гиперреактивности дыхательных путей и бронхиальной обструкции, вызываемой физической нагрузкой у спортсменов высших достижений. Представлены эпидемиологические данные по распространению бронхиальной обструкции у элитных атлетов различных видов спорта. Рассмотрены современные представления об этиологических и триггерных факторах вызываемого физической нагрузкой бронхоспазма. Подробно представлены патогенетические аспекты формирования бронхиальной обструкции у спортсменов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>airway hyper responsiveness</kwd><kwd>bronchoconstriction</kwd><kwd>sport effort</kwd><kwd>elite athletes</kwd><kwd>allergy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гиперреактивность дыхательных путей</kwd><kwd>бронхиальная обструкция</kwd><kwd>спортивные нагрузки</kwd><kwd>элитные спортсмены</kwd><kwd>аллергия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Global Initiative for Asthma (GINA). http://ginasthma.org/.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Bonini M., Palange P. Exercise-induced bronchoconstriction: new evidence in pathogenesis, diagnosis and treatment. Asthma Res Pract. 2015;1:2. DOI: 10.1186/s40733-015-0004-4.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Boulet LP, O’Byrne PM. Asthma and exercise induced bronchoconstriction in athletes. N. Engl J. Med. 2015;372:641-648. DOI: 10.1056/NEJMra1407552.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Parsons JP, Hallstrand TS, Mastronarde JG, Kaminsky DA, Rundell KW, Hull JH et al. An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction. Am J. Respir Crit Care Med. 2013;187:1016-1027. DOI: 10.1164/rccm.201303-0437ST</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Lund TK, Pedersen L., Anderson SD, Sverrild A., Backer V. Are asthma - like symptoms in elite athletes associated with classical features of asthma? Br J. Sports Med. 2009;43:1131-1135. DOI: 10.1136/bjsm.2008.054924.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Helenius I., Haahtela T. Allergy and asthma in elite summer sports athletes. J. Allergy Clin Immunol. 2000;106(3):444-450. DOI: 10.1067/mai.2000.107749.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Nystad W., Harris J., Borgen JS. Asthma and wheezing among Norwegian elite athletes. Med Sci Sports Exerc. 2000; 32(2):266-270.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Knöpfli BH, Luke-Zeitoun M., von Duvillard SP, Burki A., Bachlechner C., Keller H. High incidence of exercise-induced bronchoconstriction in triathletes of the Swiss national team. Br J. Sports Med. 2007;41:486-491. DOI: 10.1136/ bjsm.2006.030569.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Price OJ, Ansley L., Menzies-Gow A., Cullinan P., Hull JH. Airway dysfunction in elite athletes - an occupational lung disease? Allergy. 2013;68:1343-1352. DOI: 10.1111/all.12265.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Couto M., Stang J., Horta L., Stensrud T., Severo M., Mowinckel P. et al. Two distinct phenotypes of asthma in elite athletes identified by latent class analysis. J. Asthma. 2015;52:897-904. DOI: 10.3109/02770903.2015.1067321.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Van der Eycken S., Schelpea A., Marijssea G., Dilissena E., Troostersb T., Vanbelle V. et al. Feasibility to apply eucapnic voluntary hyperventilation in young elite athletes. Respir Med. 2016;111:91-93. DOI: 10.1016/j.rmed.2015.12.012.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Fitch K. An overview of asthma and airway hyper-responsiveness in Olympic athletes. Br J. Sports Med. 2012;46:413-416. DOI: 10.1136/bjsports-2011-090814.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Pohjantähti H., Laitinen J., Parkkari J. Exercise-induced bronchospasm among healthy elite cross country skiers and non-athletic students. Scand J. Med Sci Sports. 2005;15:324-328. DOI: 10.1111/j.1600-0838.2004.00423.x.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Mannix ET, Roberts M., Fagin DP, Reid B., Farber MO. The prevalence of airways hyperresponsiveness in members of an exercise training facility. J. Asthma. 2003;40:349-355. DOI: 10.1081/jas-120018634.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Stensrud T., Mykland KV, Gabrielsen K., Carlsen KH. Bronchial hyperresponsiveness in skiers: field test versus methacholine provocation? Med Sci Sports Exerc. 2007;39:1681-1686. DOI: 10.1249/mss.0b013e31813738ac.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Bjermer L., Anderson SD. Bronchial hyperresponsiveness in athletes: mechanisms for development. Eur Respir Mon. 2005:33:19-34. DOI: 10.1183/1025448x.erm3305.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Wechsler ME, Lehman E., Lazarus SC, Lemanske RF Jr, Boushey HA, Deykin A. et al. National Heart, Lung and Blood Institute’s Asthma Clinical Research Network. beta-adrenergic receptor polymorphisms and response to salmeterol. American Journal Respir Crit Care Medicine. 2006;173:519-526. DOI: 10.1164/rccm.200509-1519OC.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Denham S., Koppelman GH, Blakey J., Wjst M., Ferreira MA, Hall IP Meta-analysis of genome-wide linkage studies of asthma and related traits. Respir Research. 2008;9:1-38. DOI: 10.1186/1465-9921-9-38.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Фрейдин МБ, Огородова ЛМ, Пузырев В.П. Вклад полиморфизма генов интерлейкинов в изменчивость количественных факторов риска атопической бронхиальной астмы. Медицинская генетика. 2003;(3):130-135</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Mitsuyasu H, Izuhara K, Mao XQ, Gao PS, Arinobu Y, Enomoto T. Ile50Val variants or IL4Ra upregulates IgE synthesis and associates with atopic asthma. Nat genet. 1998;19:119-120. DOI: 10.1038/472.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Хаитов МР, Акимов В.С. Генетическая предрасположенность к развитию бронхиальной астмы и аллергии. Подходы к идентификации новых генов, ассоциированных с развитием бронхиальной астмы и атопии. Российский Аллергологический Журнал. 2004;(3):67-74</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Bougault V., Loubaki L., Joubert P., Turmel J., Couture C., Laviolette M. Airway remodeling and inflammation in competitive swimmers training in indoor chlorinated swimming pools. J. Allergy Clin Immunol. 2012;129:351-358. DOI: 10.1016/j. jaci.2011.11.010.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Helenius IJ, Tikkanen HO, Haahtela T. Occurrence of exercise induced bronchospasm in elite runners: dependence on atopy and exposure to cold air and pollen. Br J. Sports Med. 1998;32:125-129. DOI: 10.1136/bjsm.32.2.125.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Couto M., Kurowski M., Moreira A., Bullens DMA, Carlsen KH, Delgado L., Kowalski ML, Seys SF. Mechanisms of exercise-induced bronchoconstriction in athletes: Current perspectives and future challenges. Allergy. 2018;73:8-16. DOI: 10.1111/all.13224.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Bougault V., Turmel J., St-Laurent J., Bertrand M., Boulet LP. Asthma, airway inflammation and epithelial damage in swimmers and cold-air athletes. Eur Respir J. 2009;33:740-746. DOI: 10.1183/09031936.00117708.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Seys SF, Hox V., Van Gerven L., Dilissen E., Marijsse G., Peeters E. Damage-associated molecular pattern and innate cytokine release in the airways of competitive swimmers. Allergy. 2015;70:187-194. DOI: 10.1111/all.12540.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Larsson J., Anderson SD, Dahlén SE, Dahlén B. Refractoriness to exercise challenge: a review of the mechanisms old and new. Immunol Allergy Clin North Am. 2013;33:329-345. DOI: 10.1016/j.iac.2013.02.004.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Hallstrand TS, Moody MW, Aitken ML, Henderson WRJ. Airway immunopathology of asthma with exercise-induced bronchoconstriction. J Allergy Clin Immunol. 2005;116:586 593. DOI: 10.1016/j.jaci.2005.04.035</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Helenius I1, Rytilä P., Sarna S., Lumme A., Helenius M., Remes V. Effect of continuing or finishing high-level sports on airway inflammation, bronchial hyperresponsiveness, and asthma: a 5-year prospective follow-up study of 42 highly trained swimmers. J. Allergy Clin Immunol. 2002;109:962-968. DOI: 10.1067/mai.2002.124769a.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Couto M., Andrade P., Pereira M., Araujo J., Moreira P., Delgado L. Effect of competitive swimming on airway inflammation: a 3-yr longitudinal study. Pediatr Allergy Immunol. 2014;25:193-195. DOI: 10.1111/pai.12172.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Bougault V., Turmel J., Boulet LP. Airway hyperresponsiveness in elite swimmers: is it a transient phenomenon? J. Allergy Clin Immunol. 2011;127:892-898. DOI: 10.1016/j. jaci.2010.11.003.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Moreira A., Delgado L., Palmares C., Lopes C., Jacinto T., Rytilä P. Competitive swimmers with allergic asthma show a mixed type of airway inflammation. Eur Respir J. 2008;31:1139-1141. DOI: 10.1183/09031936.00175207.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Pedersen L., Lund TK, Barnes PJ, Kharitonov SA, Backer V. Airway responsiveness and inflammation in adolescent elite swimmers. J. Allergy Clin Immunol. 2008;122:322-327. DOI: 10.1016/j.jaci.2008.04.041.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Bonsignore MR, Morici G., Vignola AM, Riccobono L., Bonanno A., Profita M. Increased airway inflammatory cells in endurance athletes: what do they mean? Clin Exp Allergy. 2003;33:14-21. DOI: 10.1046/j.1365-2222.2003.01557.x.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Sue-Chu M., Karjalainen EM, Altraja A., Laitinen A., Laitinen LA, Naess AB. Lymphoid aggregates in endobronchial biopsies from young elite cross-country skiers. Am J. Respir Crit Care Med. 1998;158:597-601. DOI: 10.1164/ajrc-cm.158.2.9711012.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Green RH, Brightling CE, Woltmann G., Parker D., Wardlaw AJ, Pavord ID. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax. 2002;57:875-879.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Sue-Chu M., Karjalainen EM, Laitinen A., Larsson L., Laitinen LA, Bjermer L. Placebo-controlled study of inhaled budesonide on indices of airway inflammation in bronchoalveolar lavage fluid and bronchial biopsies in cross-country skiers. Respiration. 2000;64:417-425. DOI: 10.1159/000029541.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Mountjoy M, Fitch K, Boulet LP, Bougault V, van Mechelen W, Verhagen E. Prevalence and characteristics of asthma in the aquatic disciplines. J Allergy Clin Immunol. 2015;136:588 594. DOI: 10.1016/j.jaci.2015.01.041</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Del Giacco SR, Firinu D., Bjermer L., Carlsen KH. Exercise and asthma: an overview. Eur Clin Respir J. 2015;3:279-284. DOI: 10.3402/ecrj.v2.27984.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Anderson SD, Kippelen P. Exercise-induced bronchoconstriction: pathogenesis. Curr Allergy Asthma Rep. 2005;5:116-122. DOI: 10.1016/j.iac.2013.02.002.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Anderson SD, Kippelen P. Airway injury as a mechanism for exercise-induced bronchoconstriction in elite athletes. J. Allergy Clin Immunol. 2008;122:225-235. DOI: 10.1016/j. jaci.2008.05.001.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Bolger C., Tufvesson E., Sue-Chu M., Devereux G., Ayres JG, Bjermer L. Hyperpnea-induced bronchoconstriction and urinary CC16 levels in athletes. Med Sci Sports Exerc. 2011;43:1207-1213. DOI: 10.1249/MSS.0b013e31820750d8.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>McFadden ERJ, Ingram RHJ. Exercise-induced asthma: observations on the initiating stimulus. N. Engl J. Med. 1979;301:763-769.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Barnes PJ. Cholinergic control of airway smooth muscle. Am Rev Respir Dis. 1987;136:42-45. DOI: 10.1164/ajrc-cm/136.4_Pt_2.S42.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Kaltsatou A., Kouidi E., Fotiou D., Deligiannis P. The use of pupillometry in the assessment of cardiac autonomic function in elite different type trained athletes. Eur J. Appl Physiol Occup Physiol. 2011;111:2079-2087. DOI: 10.1007/s00421-011-1836-0.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Park C., Stafford C., Lockette W. Exercise-induced asthma may be associated with diminished sweat secretion rates in humans. Chest. 2008;134:552-558. DOI: 10.1378/chest.08-0366.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Couto M., Silva D., Santos P., Queirôs S., Delgado L., Moreira A. Exploratory study comparing dysautonomia between asthmatic and non-asthmatic elite swimmers. Rev Port Pneumol. 2015;21:22-29. DOI: 10.1016/j.rppnen.2014.05.004.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Stang J., Stensrud T., Mowinckel P., Carlsen KH. Parasympathetic activity and bronchial hyperresponsiveness in athletes. Med Sci Sports Exerc. 2016;48:2100-2107. DOI: 10.1249/ MSS.0000000000001008.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Lind H., Brudin L., Lindholm L., Edvinsson L. Different levels of sensory neuropeptides (calcitonin gene-related peptide and substance P) during and after exercise in man. Clin Physiol. 1996;16:73-82.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Wessler I., Kirkpatrick CJ. Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br J. Pharmacol. 2008;154:1558-1571. DOI: 10.1038/bjp.2008.185.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Lötvall J., Akdis CA, Bacharier LB, Bjermer L., Casale TB, Custovic A. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J. Allergy Clin Immunol. 2011;127:355-360. DOI: 10.1016/j. jaci.2010.11.037.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Weiler JM, Anderson SD, Randolph C., Bonini S., Craig TJ, Pearlman DS et al. Pathogenesis, prevalence, diagnosis, and management of exercise-induced bronchoconstriction: a practice parameter. Ann Allergy Asthma Immunol. 2010; 105(6):1-47.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Kemp JP. Exercise-induced bronchoconstriction: the effects of montelukast, a leukotriene receptor antagonist. Ther Clin Risk Manag. 2009;5:923-934.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Царев СВ, Хаитов М.Р. Роль респираторных вирусов при бронхиальной астме. Русский медицинский журнал. 2009;(2):136-139</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Leff JA, Busse WW Pearlman DS, Bronsky EA, Kemp JP. Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced bronchoconstriction. N. Engl J. Med. 1998;339:147-152.</mixed-citation></ref></ref-list></back></article>
