Russian Journal of AllergyRussian Journal of Allergy1810-88302686-682XFarmarus Print Media120610.36691/RJA1206Research ArticleAssociative relationship between atopy, HLA complex genes and other genesAstafyevaN Gastang@mail.ruShamgunovaB A-KobzevD YuSchool of Social and Health Sciences-MichailovaI Ae-Saratov State Medical University, Russia, Department of Clinical Immunology and AllergologyAstrakhan State Medical UniversityLeeds Trinity University1506201916352502042020Copyright © 2019, Pharmarus Print Media2019This review presents current data on the associative relationships of genes of the major histocompatibility complex (HLA) and other genes with atopy. Despite the long history of studying the role of HLA class genes in atopy and the introduction of modern technologies and methods, many unresolved issues remain, including the difficulties caused by the heterogeneity of the human population, the complex structure and disequilibrium of linkage between different HLA genes. 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