Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press11210.36691/RJA112ArticlesСтатьиResearch ArticleAbout the role of bacteria in patients with bronchial asthma, chronic obstructive pulmonary disease and ACOSК вопросу о роли бактерий у больных бронхиальной астмой, хронической обструктивной болезнью легких и ACOSFedoseevG BФедосеевГ Б

член-корр. РАН, з.д.н. России, доктор медицинских наук, профессор кафедры госпитальной терапии им. акад. М.В. Черноруцкого

fedoseevsp@mail.ruTrofimovV IТрофимовВ И

доктор медицинских наук, профессор, зав. кафедрой госпитальной терапии им. акад. М.В. Черноруцкого

GolubevaV IГолубеваВ И

биолог лаборатории клинической иммунологии и молекулярной диагностики

TimchikV GТимчикВ Г

кандидат медицинских наук, врач функциональной диагностики отделения функциональной диагностики № 2 научно-клинического исследовательского центра

NegrutsaK VНегруцаК В

аспирант кафедры госпитальной терапии им. акад. М.В. Черноруцкого

RazumovskayaT SРазумовскаяТ С

ведущий инженер отделения функциональной диагностики № 2 научно-клинического исследовательского центра

AleksandrinV AАлександринВ А

кандидат медицинских наук, доцент кафедры госпитальной терапии им. акад. М.В. Черноруцкого

KryakunovK NКрякуновК Н

кандидат медицинских наук, доцент кафедры госпитальной терапии им. акад. М.В. Черноруцкого

The M.V. Chernorutsky Department of Hospital Therapy of the Pavlov First State Medical University of St. PetersburgПервый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова14122018156NO6 (2018)№6 (2018)657810032020Copyright ©; 2018, Pharmarus Print MediaCopyright ©; 2018, Фармарус Принт Медиа2018Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/112

The article deals with bacterial lung microbiota in patients with bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD), bacterial inflammation of the bronchopulmonary system which can be manifested by sensitization and allergy. Also they can be a trigger with the development of bacterial inflammation. Bacteria can colonize the lungs without severe clinical, laboratory and instrumental changes. High levels of IgG to Str. pneumoniae, Neisseria perflava, Haemophilus influenza in ACOS patients can be evidence of their etiological significance. Taking into account the etiological significance of microbiota, methods of treatment of patients with COPD and BA with the use of antibiotics, vaccines and probiotics have been developed.

В статье рассматривается бактериальная микробиота легких у больных бронхиальной астмой (БА) и хронической обструктивной болезнью легких (ХОБЛ). Бактерии формируют воспаление бронхолегочного аппарата, которое может проявляться сенсибилизацией и аллергией, быть триггером с развитием бактериального воспаления. Бактерии могут колонизировать легкие без выраженной клинической, лабораторной и инструментальной симптоматики. У больных ACOS высокие уровни IgG к Streptococcus pneumoniae, Neisseria perflava, Haemophilus influenzae свидетельствуют об их этиологической значимости. С учетом этиологической значимости микробиоты разрабатываются методы лечения больных ХОБЛ и БА с использованием антибиотиков, вакцин и пробиотиков.

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