Drug allergy to cetirizine: fixed drug eruption.



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Abstract

Drug hypersensitivity reactions are one of the most complex and difficult-to-diagnose problems in the modern practice of an allergist-immunologist. Fixed drug eruption occurs in 14-22% cases of delayed-type drug allergy skin lesions. The most common triggers of fixed drug eruption are fluconazole, barbiturates, NSAIDs (more often coxibs), metamizole sodium, and antibacterial sulfonamides. Antihistamines are not typical representatives of drugs that cause drug allergies, including fixed drug erythema. However, it is important to remember that antihistamines can also be a cause of drug allergy.

The article presents a clinical case of a patient who experienced repeated fixed drug eruption reactions. Basic information about this type of drug allergy is described in detail. During the diagnostic process, patch tests and a provocation oral test with drugs had been performed, which is the gold standard for this type of diagnosis. Based on the test results, the diagnosis of fixed drug eruption to cetirizine was confirmed.

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About the authors

Elena Malkova

ФГБУ "ГНЦ Институт иммунологии" ФМБА России

Author for correspondence.
Email: Yelenafedotova98@yandex.ru
ORCID iD: 0009-0001-9457-1642

MD

Russian Federation

Tatiana S. Romanova

National Research Center — Institute of Immunology Federal Medical-Biological Agency of Russia

Email: ts_romanova@mail.ru
ORCID iD: 0000-0003-3350-3811
SPIN-code: 8027-8625

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Tatyana V. Latysheva

National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia

Email: tv.latysheva@nrcii.ru
ORCID iD: 0000-0003-1508-0640
SPIN-code: 8929-7644

MD, Dr. Sci. (Medicine), Professor

Russian Federation, Moscow

Elena A. Latysheva

National Research Center — Institute of Immunology Federal Medical-Biological Agency of Russia

Email: ealat@mail.ru
ORCID iD: 0000-0002-1606-205X
SPIN-code: 2063-7973

Dr. Sci. (Medicine)

Russian Federation, Moscow

Tatiana N. Myasnikova

National Research Center — Institute of Immunology Federal Medical-Biological Agency of Russia

Email: t_miasnikova@mail.ru
ORCID iD: 0000-0001-8491-195X
SPIN-code: 4684-3112

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

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