Development and implementation in outpatient practice of an electronic computer program “Diagnostics of bronchial asthma in children”

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BACKGROUND: Currently, the criteria for the differential diagnosis of bronchial asthma and several respiratory diseases in children, accompanied by bronchial obstruction syndrome, remain insufficiently effective. Moreover, timely administration of anti-inflammatory therapy is important.

AIM: To develop and introduce a computer program for the timely diagnosis of asthma in children and appointment of basic therapy into outpatient practice.

MATERIALS AND METHODS: A comparative comprehensive analysis of risk factors for disease development in 155 children with bronchial asthma and 155 clinically healthy children who suffered episodes of bronchial obstruction at an early age was conducted, and a computer program that allows timely diagnosis of asthma was developed. The program was tested during the observation of 68 children with episodes of bronchial obstruction.

RESULTS: Sixty-two most significant signs (disease predictors) were established, which formed the basis of the computer program “Diagnostics of bronchial asthma in children.” The application of the program in clinical conditions showed a high consistency of the result with the conclusion of an allergist-immunologist. The sensitivity and specificity of the method were 88.2% and 94.1%, respectively (p <0.05). The program was introduced into outpatient practice.

CONCLUSION: The data obtained determine the possibility of using the proposed computer program as a tool for the timely diagnosis of bronchial asthma in children.

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About the authors

Rezeda M. Faizullina

Bashkir State Medical University

ORCID iD: 0000-0002-9001-1437
SPIN-code: 6706-3639

MD, Dr. Sci. (Med.), Professor

Russian Federation, Ufa

Natalia V. Samigullina

Bashkir State Medical University; Clinical Hospital of Emergency Medical Care of the city of Ufa

Author for correspondence.
ORCID iD: 0000-0003-3415-0595
SPIN-code: 7643-3619

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, Ufa; Ufa


  1. National Program. Bronchial asthma in children. Treatment strategy and prevention. Ed. by N.A. Geppe, N.G. Kolosov, E.G. Kondyurin, et al. 6th ed. revised and updated. Moscow: MedKom-Pro; 2022. (In Russ).
  2. Balabolkin II, Smirnov IE. Allergic bronchial asthma in children: features of the development and modern therapy. Russian pediatric journal. 2018;21(1):38–45. (In Russ). doi: 10.18821/1560-9561-2018-21-1-38-45
  3. Kalliola S, Malmberg LP, Malmstrom K, et al. Airway hyperresponsiveness in young children with respiratory simptoms: A five-year follow-up. Ann Allergy Asthma Immunol. 2019;122(5): 492–497. doi: 10.1016/j.anai.2019.02.025
  4. Denisova AR, Geppe NA, Kolosova NG, et al. Modern approaches to optimizing the treatment of bronchial asthma in children. Problems of modern pediatry. 2021;16(4):158–165. (In Russ). doi: 10.20953/1817-7646-2021-4-158-164
  5. Ovsyannikov DY, Furman EG, Eliseeva TI. Bronchial asthma in children. Moscow: RUDN University; 2019. 211 р. (In Russ).
  6. Geppe NA, Kolosova NG. The importance of modern guidelines in improving the monitoring and treatment of bronchial asthma in children (review). Vestnik Smolenskoj gosudarstvennoj medicinskoj akademii. 2017;16(3):165–168. (In Russ).
  7. GINA. Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma; 2021. Available from: Accessed: 10.02.2022.
  8. Ovsyannikov DY, Bolibok AM, Haled M, et al. Heterogeneity of bronchoobstructive syndrome and bronchial asthma in children: Diagnostic difficulties. Difficult patient. 2017;15(1-2):43–52. (In Russ).
  9. Ovsyannikov DY. Challenges and errors in the diagnosis and treatment of asthma in children. Medicinskij sovet. 2017;(1):100–106 (In Russ). doi: 10.21518/2079-701X-2017-1-100-106
  10. Yang CL, Simons E, Foty RG, et al. Misdiagnosis of asthma in schoolchildren. Pediatr Pulmonol. 2017;52(3):293–302. doi: 10.1002/ppul.23541
  11. Ovsyannikov DY, Furman EG, Eliseeva TI. Bronchial asthma in children. Moscow: RUDN University; 2019. 211 р. (In Russ).
  12. Ivanova NA. Recurrent bronchial obstruction and asthma in children during the first five years of life. Russian bulletin of perinatology and pediatrics. 2016;61(5):64–69. (In Russ). doi: 10.21508/1027-4065-2016-61-5-64-69
  13. Jong CC, Pedersen ES, Goutaki M, et al. Do clinical investigations predict long-term wheeze? A follow-up of pediatric respiratory outpatients. Pediatr Pulmonol. 2019;54(8):1156–1161. doi: 10.1002/ppul.24347
  14. Papadopoulos NG, Arakawa H, Carlsen KH, el al. International consensus on (ICON) pediatric asthma. Eur J Allergy Clin Immunol. 2012;67(8):976–997. doi: 10.1111/j.1398-9995.2012.02865.x
  15. Martinez FD. The state of asthma research: considerable advances but still a long way to go. An J Respir Crit Care Med. 2019; 199(4):397–399. doi: 10.1164/rccm.201901-0013ED
  16. Davidenko EV. Prediction of the development of bronchial asthma in children who have had acute obstructive bronchitis at an early age. Belgorod state university scientific bulletin. Medicine. Pharmacy. 2014;(4):89–91. (In Russ).
  17. Bush A. Pathophysiological mechanisms of asthma. Front Pediatr. 2019;(7):68. doi: 10.3389/fped.2019.00068
  18. Geppe NA, Ivanova NA, Kamaev AV, et al. Bronchial obstruction on the background of acute respiratory infection in preschool children; diagnosis, differential diagnosis, therapy and prevention. Moscow: MedKom-Pro; 2019. 80 р. (In Russ).
  19. Hesselmar B, Saalman R, Wennergren G, et al. An index to predict asthma in wheezing young children produced promising initial results. Acta Paediatr. 2017;106(9):1532–1533. doi: 10.1111/apa.13916
  20. Wi CI, Park MA, Juhn YJ. Development and initial testing of Asthma predictive index for a retrospective study: an exploratory study. J Asthma. 2015;52(2):183–190. doi: 10.3109/02770903.2014.952438
  21. DeVries A, Vercelli D. Early predictors of asthma and allergy in children: the role of epigenetics. Curr Opin Allergy Clin Immunol. 2015;15(5):435–439. doi: 10.1097/ACI.0000000000000201
  22. Rybakova OG, Fedorov IA. Diagnosis of bronchial asthma in young children. Doktor Ru. 2019;(9):43–45. (In Russ). doi: 10.31550/1727-2378-2019-164-9-43-45
  23. Zajceva SV, Zastrozhina AK, Zajceva OV, Snitko SY. Phenotypes of bronchial asthma in children: from diagnosis to treatment. Prakticheskaya pul’monologiya. 2018;(3):76–87. (In Russ).
  24. Geppe NA, Kondyurina EG, Revyakina VA, et al. Therapy of bronchial asthma in children: age-related aspects. Pediatriya. Consilium Medicum. 2021;(2):113–122. (In Russ). doi: 10.26442/26586630.2021.2.200928
  25. Gubler EV. Computational methods of analysis and recognition of pathological processes. Leningrad: Meditsina; 1978. 294 р. (In Russ).
  26. Dashutina EV, Bloshchickij VP. Development and implementation of an algorithm for assessing the informative value of signs in the diagnosis of diseases. (In Russ). Available from: Accessed: 10.02.2022.
  27. Rebrova OY. Statistical analysis of medical data. Moscow: MediaSfera; 2006. 312 р. (In Russ).
  28. Grigor’ev SG, Lobzin YV, Skripchenko NV. The role and place of logistic regression and ROC analysis in solving medical diagnostic problems. Zhurnal infektologii. 2016;8(4):36–45. (In Russ). doi: 10.22625/2072-6732-2016-8-4-36-45
  29. Order of the Ministry of Health of the Russian Federation of June 2, 2015 N 290n “Ob utverzhdenii tipovykh otraslevykh norm vremeni na vypolnenie rabot, svyazannykh s poseshcheniem odnim patsientom vracha-pediatra uchastkovogo, vracha-terapevta uchastkovogo, vracha obshchei praktiki (semeinogo vracha), vracha-nevrologa, vracha-otorinolaringologa, vracha-oftal’mologa i vracha-akushera-ginekologa”. Available from: Accessed: 10.02.2022.
  30. Order of the Ministry of Health of the Russian Federation of 10.05.2017 No. 203n «Ob utverzhdenii kriteriev ocenki kachestva medicinskoj pomoshchi». Available from: Accessed: 10.02.2022.

Supplementary files

Supplementary Files
1. Fig. 1. The main sections and the result of the program.

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2. Fig. 2. Certificate of state registration of the program «Diagnostics of bronchial asthma in children».

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3. Fig. 3. Comparison of the verification of the diagnosis of asthma according to the examination of a pediatrician, an allergist-immunologist and the result of the computer program «Diagnostics of bronchial asthma in children» in children of early and preschool age with relapses of obstructive syndrome, %. χ2=0,025; р <0,05.

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4. Fig. 4. ROC-curve of the studied method.

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5. Fig. 5. Guidelines for the diagnosis of bronchial asthma in children.

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