Modern H1- antihistamines in the treatment of allergic rhinitis: focus on bilastine

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Abstract

The second generation of H1-antihistamines is approved for the stepwise treatment of seasonal and perennial allergic rhinitis in adults and children by international and national guidelines. They reduce the severity of nasal and ocular symptoms of rhinitis and improve the quality of life of patients.

Bilastine, a piperidine derivative, is a novel H1-antihistamine. It has a potent and selective effect on H1- receptors and a rapid onset and long duration of action and substantially reduces nasal and ocular symptoms of seasonal and perennial allergic rhinitis. Bilastine has no clinically substantial hepatic metabolism and has a high safety profile: it has no sedative effect, does not affect cognitive functions, has no cardiotoxic effects, and does not interact with alcohol and benzodiazepines in normal and high doses. Tachyphylaxis does not develop despite long-term (up to 1 year) use.

Bilastine is registered for clinical use in adults and children aged >12 years. The results of clinical and experimental studies have demonstrated that bilastine has many of the features of modern H1-antihistamines recommended by international guidelines.

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About the authors

Alexander V. Emelyanov

North-Western Medical University named after I.I. Mechnikov

Author for correspondence.
Email: emelav@inbox.ru
ORCID iD: 0000-0002-8574-6869
SPIN-code: 8036-2985

MD, Dr. Sci. (Med.), Professor

Russian Federation, 41 Kirochnaya street, 191015 Saint-Petersburg

Galina R. Sergeeva

North-Western Medical University named after I.I. Mechnikov

Email: sergreevagr@mail.ru
ORCID iD: 0000-0003-1544-4336
SPIN-code: 2474-2933

Cand. Sci. (Med.), Assistant

Russian Federation, 41 Kirochnaya street, 191015 Saint-Petersburg

Evgenia V. Leshenkova

North-Western Medical University named after I.I. Mechnikov

Email: leshenkova@mail.ru
ORCID iD: 0000-0003-4616-3166
SPIN-code: 1078-6570

MD, Cand. Sci. (Med.)

Russian Federation, 41 Kirochnaya street, 191015 Saint-Petersburg

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