Vitamin D and chronic spontaneous urticaria: searching for algorithms of personalized therapy

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Today, we can see a great interest in vitamin D because it participates in the regulation of many metabolic processes, and its deficiency is associated with the development of various diseases. Chronic spontaneous urticaria (CSU) is the disease that affects the quality of patient’s life, and the existing strategy of patient management is not always sufficiently effective. Nowadays, there is enough information about the role of vitamin D deficiency and the severity of CSU. That is why it is important to study not only therapeutic schemes, but also a role of genetic variability that may have an impact on vitamin D levels.

Such studies will help to personalize the treatment schemes for patients with CSU. At the same time, the focus of these studies should be not only on the receptor and vitamin D binding protein, but also on P450 system, which plays a key role in the vitamin D metabolism.

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About the authors

Ilya V. Kukes

International Association of Clinical Pharmacologists and Pharmacists

Author for correspondence.
ORCID iD: 0000-0003-1449-8711

Head of the Scientific and Clinical Department, PhD

Russian Federation, Moscow

Elena Yu. Borzova

I.M. Sechenov First Moscow State Medical University (Sechenov University)


Professor at the Department of Skin and Venereal Diseases, MD, PhD, Professor

Russian Federation, Moscow

Natalya M. Nenasheva

Russian Medical Academy of Continuing Professional Education

ORCID iD: 0000-0002-3162-2510

Head of the Department of Allergology and Immunology, MD, PhD, Professor

Russian Federation, Moscow

Dmitriy A. Sychev

Russian Medical Academy of Continuing Professional Education

ORCID iD: 0000-0002-4496-3680

Head of the Department of Clinical Pharmacology, MD, PhD, Professor

Russian Federation, Moscow


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Supplementary files

Supplementary Files
1. Figure 1. (Vitamin D3 (a) and D2 (b) metabolism with the participation of various cytochrome P450 (CYP) enzymes)

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