Oral food challenges in clinical practice: a missing element of food allergy diagnosis in Russia

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Food allergy is one of the most prevalent allergic conditions, causing reduction in patient quality of life. It is linked with high levels of anxiety due to potential life-threatening reactions, and high economic burden for a healthcare system. Food allergy affects approximately 5 to 10% of children around the world. In Russian Federation the diagnosis of food allergy is primarily based on clinical history, laboratory test results, examination and elimination of suspected food. Meanwhile oral food challenge (OFC) is considered a “gold standard” of food allergy diagnosis by most of professional bodies nationally and internationally. OFC is a diagnostic procedure involving administration of a causative allergen in gradually increasing amount under a close medical supervision. The method is safe, highly specific and sensitive and is widely used around the world for more than 45 years. The main goals of OFC include food allergy diagnosis and presence of tolerance evaluation, which may result in diet expansion. OFC may also help establishing both, reaction severity and dose needed to elicit reaction, which may further assist with alleviation of patients’ anxiety. In this paper we discuss existing approaches to the diagnosis of food allergy in Russian Federation and review available recommendations on OFC outlined in international guidelines.

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About the authors

Daria M. Levina

The Speranskiy Children’s Hospital

Email: LevinaDasha95@mail.ru
ORCID iD: 0000-0001-6322-7294
SPIN-code: 8112-4185

MD, Specialist Trainee in Pediatrics

Russian Federation, Moscow

Ilya A. Korsunskiy

The Speranskiy Children’s Hospital

Email: iliakors@gmail.com

Head of Allergy and Immunology Department, MD, PhD

Russian Federation, Moscow

Daniel B. Munblit

Imperial College London

Author for correspondence.
Email: daniel.munblit08@imperial.ac.uk
ORCID iD: 0000-0001-9652-6856

Honorary Senior Lecturer. Inflammation, Repair and Development Section, National Heart & Lung Institute

United Kingdom, St. Mary`s Campus, Wright Fleming Building, Norfolk Place, Paddington, W2 1PG


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