Fresh look on the urticaria problem.

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Introduction. Nowadays urticaria is one of the most common diseases. According to the International Guidelines for the definition, classification, diagnosis and management of urticaria, 2nd-generation H1-antihistamines are recommended to be used as the first-line and second-line therapy. Omalizumab, a humanized monoclonal anti-IgE antibody, is assumed to be the third-line therapy in urticaria treatment.

Summary. In this review we discuss the latest data on pathogenetic mechanisms of urticaria, focusing on the search of the new targets for the therapy. We represent the latest clinical trials of the new biological treatment for urticaria. Safety and efficiency of 4-folds higher therapeutical dose of the 2nd generation H1-antihistamines, and criteria for personalized selection of the antihistamines are discussed.

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Alla O. Litovkina

NRC Institute of Immunology FMBA of Russia

Author for correspondence.
ORCID iD: 0000-0002-5021-9276

graduate student in Department of Skin Allergy and Immunopathology

Russian Federation, 115522, 24 Kashirskoe shosse, Moscow

Eugenii V. Smolnikov

NRC Institute of Immunology FMBA of Russia

ORCID iD: 0000-0003-1302-4178

graduate student in Department of Skin Allergy and Immunopathology

Russian Federation, 24, Kashirskoye shosse, Moscow, 115522

Olga G. Elisyutina

NRCI Institute of Immunology FMBA of Russia

ORCID iD: 0000-0002-4609-2591

MD, PhD, DSc, leading researcher of the Department of Skin allergy and immunopathology

Russian Federation, 24, Kashirskoye shosse, Moscow, 115522

Elena S. Fedenko

NRS Institute of Immunology FMBA of Russia

ORCID iD: 0000-0003-3358-5087
SPIN-code: 5012-7242
Scopus Author ID: 6603386923
ResearcherId: P-6912-2015

MD, PhD, DSc, professor, head of the Department of Skin allergy and immunopathology

Russian Federation, 24, Kashirskoye shosse, Moscow, 115522


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