Features of immunopathogenesis of atopic dermatitis

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


 Atopic dermatitis is one of the most common allergic diseases with severe course, which affects the skin. This disease is genetically determined and has a chronic course. Atopic dermatitis is also one of the commonest diseases (between 20% and 40% of all skin disorders) and affects patients of both sexes across the globe. Such high rate of morbidity, onset in early childhood, often continuous relapsing course and a trend toward gradual increase of tolerance to traditional therapies makes the issue of detalization of pathogenesis of atopic dermatitis particularly topical. Immune cells play one of the major roles in the pathogenesis of atopic dermatitis. This article will systematically review the main available to date information on participation immune cells in the pathogenesis of atopic dermatitis.

Full Text

Restricted Access

About the authors

Olga O. Pobezhimova

Samara State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: ImmunologSamara888@yandex.ru
ORCID iD: 0000-0001-9593-4807

graduate student of department of the general and clinical microbiology, allergology and immunology

Russian Federation, 18, Gagarina str., Samara, 443099

Alexsander V. Zhestkov

Samara State Medical University, Ministry of Health of Russia

Email: avzhestkov@yandex.ru
ORCID iD: 0000-0002-3960-830X

MD, PhD, Professor, Chief of Department of Microbiology, Immunology and Allergology

Russian Federation, 18, Gagarina str., Samara, 443099

Olga S. Sidorova

Samara State Medical University, Ministry of Health of Russia

Email: rambleruse@rambler.ru
ORCID iD: 0000-0002-9183-745X

Candidate of Medical Sciences, Associate Professor of the Department of the general and clinical microbiology, allergology and immunology

Russian Federation, 18, Gagarina str., Samara, 443099

Vera V. Kulagina

Private institution educational organization of higher education “Мedical University Reaviz”

Email: vvksam@mail.ru
ORCID iD: 0000-0002-8824-0046

MD, PhD, Associate Professor of the Department of Clinical Medicine

Russian Federation, 227, Chapayevskaya str., Samara, 443001


  1. Kaznacheevа LF, Ishkova NS, Kaznacheev KS, Pimenova NV. Food allergy in children: clinic, diagnosis, treatment. Under the editorship of Novosibirsk. 2014:74.
  2. Gomberg MA, Soloviev A.M., Akovbyan V.A. Atopic dermatitis. Russian Medical Journal. 1998;6(20):30-35. doi: 10.1001/jama.280.20.1735.
  3. Children’s dermatovenerology. Under the editorship of Gorlanova IA. M.: Publishing Center Academy. 2012:352. doi: 10.1037/e578762011-001.
  4. Koltukov VK, Kazyukova TV, Hayrapetyan AS, Antipova NV. Atopic dermatitis in childhood. Medical advice. 2015;1:60-65.
  5. Visual immunology. Under the editorship of Burmester GR, Petsutto A. M.: BINOM. Knowledge Laboratory. 2009:320. doi: 10.1016/s0065-2776(08)60564-7.
  6. Federal clinical guidelines. Dermatovenerology 2015: Diseases of the skin. Sexually transmitted infections. 5th ed., Revised. and add. M.: Business Express. 2016:768.
  7. Yeo Jin Im, Dong Hee Kim. Factors associated with the resistance of schoolchildren with atopic dermatitis. J Clinical Nursing. 2012;29(1):24-27. doi: 10.1111/j.1525-2702.2011.03750.x.
  8. Klaus Wolf, Lowell A. Goldsmith, Stephen I. Katz and others. Fitzpatrick’s dermatology in clinical practice: 3 t.; trans. from English; total ed. Acad. AA Kubanova. M.: Publishing house Panfilova; Laboratory of knowledge. 2012;1:2000. doi: 10.1111/j.1524-4725.2008.34211.x.
  9. Luss LA. The role of psychosomatic disorders in atopic dermatitis. Doctor.Ru. 2010;2(53):55-58.
  10. Bulina OV, Gorlanov IA, Kalinina NM. Parameters of the cytokine immunity link in older children with atopic dermatitis. Allergology. 2004;(1):24-30. doi: 10.3109/9781420077995-7.
  11. Pogorelova EI, Pochivalov AB, Panina OA, Shulga MA, Gudkova AN, Khomutova LN. A modern view of the immunopathogenesis of atopic dermatitis. Medicine: theory and practice. 2019;4(1):157-163.
  12. Skripkin YK. Skin and sexually transmitted diseases. A textbook for doctors and students of medical universities. M.: Triad-Farm. 2005:688.
  13. Khaitov RM. Immunology. 3rd ed., Revised. and add. M.: GEOTAR-Media. 2016:496.
  14. Zagreshenko DS, Klimov VV, Denisov AA, Salikov TI, Firsov EC. Cytokines of the “skin window” in atopic dermatitis. Bulletin of Siberian medicine. 2009;8(3):10-13. doi: 10.20538/1682-0363-2009-3-32-36.
  15. Boguniewicz M, Leung DY. Recent insights into atopic dermatitis and implication for management of infectious complications. Allergy ClinImmunol. 2011;1(127):4-17. doi: 10.1016/j.jaci.2009.11.027.
  16. Beckmann MP., Cosman D, Fanslow W, Maliszewski CR, Lyman SD. The interleukin-4 receptor: structure, function and signal transduction. Chem Immun. 1992;51:107-134. doi: 10.1159/000319083.
  17. He X, Smirnova I. Defective LPS signaling in C3H/HeJ and C57Bl/10ScCr mice: mutations in Tlr4 gene. Science. 2000;282:15-19. doi: 10.1126/science.282.5396.2085.
  18. Westergaard C, Delerain M, Hesser B, Gronchoy S, Larsen. Expression of the T-helper-2 specific chemokine receptor CCR4 on CCR10-positive lymphocytes in the skin with atopic dermatitis. J British Journal of Dermatology. 2003;149(3):15-19. doi: 10.1046/j.1365-2133.2003.05505.x.
  19. Furue M, Yamamura K, Kido-Nakahara M. Emerging role of interleukin-31 and interleukin-31 receptor in atopic dermatitis. J Allergy. 2018;73(1):29-36. doi: 10.1111/all.13239.
  20. Gitter J, Shemer A, Suarez-Farinas M. Progressive action of Th2/Th22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. J Allergy Clin. Immunol. 2012;130(6):1344-1354. doi: 10.1016/j.jaci. 2012.07.012.
  21. Malik K, Heitmiller K, Czarnowicki T. An Update on the Pathophysiology of Atopic Dermatitis. Dermatol Clin. 2017;35(3):317-326. doi: 10.1016/j.det.2017.02.006.
  22. Macaubas C, de Klerk N, Holt B. Association between antenatal cytokine production and the development of atopy and asthma at age 6 years. J Lancet. 2003;362(9391):1192-1197. doi: 10.1016/s0140-6736(03)14542-4.
  23. Neaville W, Tisler C, Bhattacharya A. Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life. J Allergy Clin Immunol. 2003;112(4):740-746. doi: 10.1016/s0091-6749(03)01868-2.
  24. Prescott S, King B, Strong T, Holt P. The value of perinatal immune responses in predicting allergic disease at 6 years of age. J Allergy. 2003;58:1187-1194. doi: 10.1034/j.1398-9995.2003.00263.x.
  25. Zang Y, Collier F, Naselli G. Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic Th2-type immunity associated with development of food allergy. J Sci Transl Med. 2016;8(321):321. DOI: 10.101126/scitranslmed.aad4322.

Supplementary files

There are no supplementary files to display.

Copyright © Pharmarus Print Media, 2020

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies