Dynamic stabilometry and immunological patterns of chronic fatigue syndrome in patients with various types of multiple sclerosis

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Chronic fatigue (XY), along with motor and coordination disorders, is one of the most common syndromes in multiple sclerosis (MS). In spite of certain successes in the pathogenetic treatment of MS, the correction of the chronic fatigue syndrome (CFS) remains completely unresolved. This report presents preliminary positive experience on the use of integrated reabilitation using the biofeedback method (BFB). The effectiveness of this method for the treatment of patients with MS is shown. Recommendations are made about the possibility of using this method in patients with MS with varying severity of neurological deficit

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About the authors

A S Shagaev

Russian State Medical Universite; Institute of Cell Biophysics RAS; Russian Academy of Sciences, Hospital №1 in Pushchino

Author for correspondence.
Email: info@rusalljournal.ru

Department of Neurology and Neurosurgery

Moscow, Russia

A N Boyko

Russian State Medical Universite

Email: info@rusalljournal.ru

Department of Neurology and Neurosurgery

Moscow, Russia

B V Bakharev

Institute of Cell Biophysics RAS

Email: info@rusalljournal.ru
Moscow, Russia


  1. Алексеева Т.Г., Бойко А.Н., Гусев Е.И. Спектр нейропсихологических изменений при рассеянном склерозе. Ж.Невр.и псих., Спец.выпуск «Рассеянный склероз».2000;11:15-20.
  2. Алексеева Т.Г., Еникополова Е.В., Садальский Е.В., и др.Комплексный подход к оценке когнитивной и эмоционально-личностной сфер у больных рассенным склерозом. Ж.Невр и псих, Спец. выпуск «Рассеянный склероз».2002;1:20-26.
  3. Батышева Т. Т. Система медицинской реабилитации двигательных нарушений у неврологических больных в амбулаторных условиях: Автореф. дисс. на соискание уч.степени д.м.н.-Москва., 2005.-64с.
  4. Батышева. Т. Т. Система медицинской реабилитации двигательных нарушений у неврологических больных в амбулаторных условиях: Автореф.дисс. на соискание уч.степени д.м.н.-Москва., 2005.-5с.
  5. Бахарев Б.В. Статистическая обработка данных. Критерии проверки данных. Пакет программ «статистика», материалы по математическому обеспечению ЭВМ. Сб.трудов,-г.Пущино.,-1989.- выпуск 15,- 34 с.
  6. Гехт Б.М., Меркулова Д.М., Касаткина Л.Ф., Самойлов М.И. Клиника, диагностика и лечение демиелинизирующих полиневропатий. Невр. Журн.1996;1:12-17.
  7. Гусев Е.И., Бойко А.Н.,Завалишин И.А.Эпидемиологические исследования рассеянного склероза. Методические рекомендации.-Москва.- 2003. -№ 2003/82:4-32.
  8. Гусев Е.И.,Бойко А.Н., Завалишин. И.А.Рассеянный склероз и другие демиелинизирующие заболевания: рук. для врачей - М.: «Миклош», 2004. -8с
  9. Демина М.Л., Попова Н.Ф. Симптоматическая терапия рассеянного склероза. J. ConsiliumMedicum. 2002.,т.4; 2: 6-9
  10. Шмидт Т.Е.,Елагина И.А., Яхно Н.Н. Синдром утомляемости при различных типах течения рассеянного склероза. Невр.Журн.2012; 3:12-19.
  11. Amato M.P ,Portaccio E. Management option in multiple sclerosis-assotiated fatigue. Expert OpinPharmacother. 2012; 13:207-216: doi: 10.1517/14656566.2012.647767. [Pub Med].
  12. Berlestmann F.W., Polman C.H., van Diemann HAM., et all, A comparison between 4-aminopyridine and 3,4-di-aminopyridine in the treatment of multiple sclerosis. Ann Neurol 1992, 32:256.
  13. Bever C.T., Panitch H.S., Anderson P.A., et al. The effects of 4-aminopyridine in multiple sclerosis patients : results of randomized, placebo-controled, double-blind , consentration-controlled, crossover trial. Neurology 1994, 44: 1054-1059.
  14. Carro E,Nunez A, Busiguina S, Torres-Aleman I. Circulating insulin like growth factor I mediates effect of exercise on the brain. J, Neurosci. 2000; 20(8): 2926-2933.
  15. Carro E, Trijo JL, Busiguina S, Torres-Aleman I. Circulating insulin like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J.Neurosci. 2001; 21(15): 5678-5684.
  16. Сastellano V., Patel D.I, White L I. Cytokine responses to acute and chronic exercise in multiple sclerosis. J. ApplPhisiol. 2008; 104:1697-1702. Doi: 10.1152/ japplphysiol.00954.2007[Pab. Med]
  17. Castellano, V. Patel, DI, White, LJ. Cytokine responses and PGC1 in inflammation and chronic disease. Nature. 2008; 454 (24); 463-469.
  18. Flacheneker P, Bihler I. Cytocine mRNA ex-pression in patients with MS and fatigue.Mult.Scler. 2004; 10.165-169. doi: 10.1191/1352458504ms 991oa. [Pab. Med].
  19. Gold SM, Kruger S, Ziegler KJ, Krieger T, Schulz KH, Otte C, Heesen C. Endocrine and Immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depres-sion. J. Neurol-NeurosurgPsychiatr. 2011; 82:814-818. Doi: 10.1136/ jnnp.2010.2300.29.[Pub Med ].
  20. Golzari, Z, Shadkhis, F, Soudi, S, Kordi, MR, Hasmeri , SM. Combined exercise training redices IFN.-gamma and. IL-17 levels plasma and the suripheral blood mononuclear cells in women with multiple sclerosis. International Immunopharmacology. 2010; 10:1415-1419.
  21. Gottschalk M. Kumpfel T, Flachenecker P, Uhr M, Trenkwalder C, Holsboer F, Weber F. Fatigue and regulation of the hypothalamo-pituitary-adrenal axis in multiple sclerosis. Arch Neurol. 2005 ; 62:277-280. Doi. 10.1001/archneur.62.2.277.[Pab. Med]
  22. Hessen C, Nawrath L, Reich N, Schulz KH, Gold SM. Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour. J. NeurolNeurosurgPsychitr. 2006; 77:34-39. doi: 10.1136/jnnp. 2005.065805. [Pab Med].
  23. Hessen, C, Gold. SM, Hartmann, S, Mladek.,,,M, Reer, R, Braumann, KM, Wiedemann. K, Schulrz, KH. Endocrine and cytokine responses to standardized physical stress in multiple sclerosis. Brain. Behavior and Immunity. 2003; 17:473-481.
  24. Kurtzke J.F. Rating neurological impairment in multiple sclerosis and expanded disability status scale (EDSS), Neurology 1983; 33, 1444-52.
  25. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50:121-127
  26. Schulz KN, Gold SM, Witte et al. Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis. J. Neurol Sci. 2004; 225(1-2): 11-18)
  27. The multiple sclerosis quality of life inventory: A User s Manual. National Multiple Sclerosis., 1999; p.3.
  28. White, LJ, Castellano, V. McCoy. SC. Cytokine responses to resistansetraning in people with multiple sclerosis. Journal of Sports Scienes. 2006; 24(8): 911-914.
  29. Zwarts MJ, Bleijenberg G, van Engelen BG. « Qinical neurophysiology of fatigue», Qinical neurophysiology, vol.119.no. I.pp.2-10. 2008. View at Publisher.



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