Polymorphism in genes encoding xenobiotic-metabolizing enzymes (GSTM1 and GSTT1) and the risk of asthma onset in Moldovan and other ethnic groups: a meta-analysis



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Abstract

Background. The aim of the study was to examine the association of the risk of asthma onset with polymorphisms in genes encoding proteins xenobiotic metabolizing enzymes (GSTT1 and GSTM1) in Moldovans and other ethnic groups using the meta-analysis method. Methods. A meta-analysis of the association of genetic polymorphism of GSTT1 and GSTM1 genes and the risk of asthma development in 180 Moldovan subjects in comparison with published data on various ethnogeographical affiliations was performed. Results. The meta-analysis results were based on sixteen studies which included a total number of 3873 patients and 4863 healthy individuals. The meta-analysis showed an increased risk of disease development in subjects who are carriers of the GSTM1 null genotype (odds ratio of the cumulative risk was 1,29; 95% CI 1,09-1,54), whereas the GSTT1 0/0 genotype was associated with a 1,32 fold increase of the cumulative risk of asthma onset (95% CI 0,99-1,75). Conclusion. The obtained results suggest that the risk of asthma development is associated with the deletion polymorphism in genes encoding proteins xenobiotic metabolizing enzymes (GSTT1 and GSTM1), but the mechanisms of the disease also depend on the gene-by-gene and gene-environment interactions.

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About the authors

L V Vasilos

Institute for Maternal and Child Healthcare, Scientific Department of Pediatrics

Chisinau, Republic of Moldova

O N Kyrstya

Institute for Maternal and Child Healthcare, Scientific Department of Pediatrics

Email: olgacirstea78@gmail.com
Chisinau, Republic of Moldova

T E Ivashchenko

Ott's Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences

Laboratory of Prenatal Diagnostics & Inherited Diseases

A N Kozhokaru

Institute for Maternal and Child Healthcare, Scientific Department of Pediatrics

Chisinau, Republic of Moldova

M V Aseyev

Ott's Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences

Laboratory of Prenatal Diagnostics & Inherited Diseases

M G Arama

Institute for Maternal and Child Healthcare, Scientific Department of Pediatrics

Chisinau, Republic of Moldova

A I Horodishtyanu-Banuh

Institute for Maternal and Child Healthcare, Scientific Department of Pediatrics

Chisinau, Republic of Moldova

D V Savoskina

Institute for Maternal and Child Healthcare, Scientific Department of Pediatrics

Chisinau, Republic of Moldova

References

  1. Weiss S.T., Raby B.A., Rogers A. Asthma genetics and genomics. Curr. Opin. Genet. Dev. 2009, v. 19, p. 279-282.
  2. Hayes J., Strange R. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology. 2000, v. 61, p. 154-166.
  3. Moher D., Liberati A., Tetzlaff J. et al. The PRISMA Group: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009, v. 6, nr. 7: e1000097.
  4. Review Manager (RevMan) [Computer program]. Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration. 2011.
  5. Fryer A.A., Bianco A., Hepple M. et al. Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma. Am. J. Resp. Crit. Care Med. 2000, v. 161, p. 1437-1442.
  6. Holla L.I., Stejskalova A., Vasku A. Polymorphisms ofthe GSTM1 and GSTT1 genes in patients with allergic diseases in the Czech population. Allergy. 2006, v. 61, p. 265-267.
  7. Ivaschenko T., Sideleva O., Baranov V. Glutathione-S-transferase μ and theta gene polymorphisms as new risk factors of atopic bronchial asthma. J. Mol. Med. 2002, v. 80, p. 39-43.
  8. Вавилин В.А., Макарова С.И., Ляхович В.В., Гавалов С.М. Ассоциация полиморфных ферментов биотрансформации ксенобиотиков с предрасположенностью к бронхиальной астме у детей с наследственной отягощенностью и без таковой. Генетика. 2002, № 4, с. 539-545.
  9. Брагина Е.Ю., Фрейдин М.Б., Тен И.А., Огородова Л.М. Полиморфизм генов биотрансформации ксенобиотиков GSTT1, GSTM1, CYP2E1 и CYP2C19 у больных атопической бронхиальной астмой. Бюллетень СО РАМН. 2005, №. 117, с. 121-125.
  10. Иванов В.П., Полоников А.В., Солодилова М.А. и соавт. Анализ ассоциации делеционных полиморфизмов генов глутатион s-трансфераз GSTM1 и GSTT1 с предрасположенностью к бронхиальной астме и особенностями ее клинических проявлений в курской популяции. Курский научно-практический вестник «Человек и его здоровье». 2005, № 3, с. 49-55.
  11. Freidin M.B., Bragina E.Y., Ogorodova L.M., Puzyrev V.P. Polymorphism of the theta1 and mu1 glutathione s-transferase genes (GSTT1, GSTM1) in patients with atopic bronchial asthma from the West Siberian region. Mol Biol (Mosk). 2002, v. 36, p. 630-634.
  12. Saadat M., Saadat I., Saboori Z., Emad A. Combination of CC16, GSTM1, and GSTT1 genetic polymorphisms is associated with asthma. J. Allergy Clin. Immunol. 2004, v. 113, p. 996-998.
  13. Tamer L., Calikoglu M., Ates N.A. et al. Glutathione-s-trans-ferase gene polymorphisms (GSTT1, GSTM1, GSTP1) as increased risk factors for asthma. Respirology. 2004, v. 9, p. 493-498.
  14. Lee Y.L., Hsiue T.R., Lee Y.C. et al. The association between glutathione S-transferase P1, M1 polymorphisms and asthma in Taiwanese schoolchildren. Chest. 2005, v. 128, p. 1156-1162.
  15. Ercan H., Birben E., Dizdar E.A. et al. Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma. J. Allergy Clin. Immunol. 2006, v. 118, p. 1097-1104.
  16. Kamada F., Mashimo Y., Inoue H. et al. The GSTP1 gene is a susceptibility gene for childhood asthma and the GSTM1 gene is a modifier of the GSTP1 gene. Int. Arch. Allergy Immunol. 2007, v. 144, p. 275-286.
  17. Lee Y.L., Lee Y.C., Guo Y.L. Associations of glutathione S-trans-ferase P1, M1, and environmental tobacco smoke with wheezing illness in school children. Allergy. 2007, v. 62, p. 641-647.
  18. Mak J.C., Ho S.P., Leung H.C. et al. Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics. Clin. Exp. Allergy. 2007, v. 37, p. 1150-1157.
  19. Hanene C., Jihene L., Jamel A. et al. Association of GST genes polymorphisms with asthma in Tunisian children. Mediat Inflamm. 2007, v. 195, p. 64.
  20. Gilliland F.D., Li Y.F., Dubeau L. et al. Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. Am. J. Respir. Crit. Care. Med. 2002, v. 166, p. 457-463.

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