AGE-RELATED PATHOGENTIC SPECIFICITY OF CYTOKINE PROFILE IN ATOPIC DERMATITIS PATIENTS



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Abstract

Background. In this article the results of own research of the cytokine profile in atopic dermatitis (AD) adults and children depending on age are provided. Materials and methods. 88 patients with AD (54 children aged from 1 year to 16 years old and 24 adults aged from 21 years to 56 years old) were included in the study. Cytokine profile of a number of cytokines: IL-4, IL-5, IL-22, IL-31, IL-33, and transforming growth factor TGFβ1, eotaxin, eotaxin2 was examined. Results. Significant differences in IL-22, CC chemokines (eotaxin and eotaxin-2) and TGFβ levels depending on the age and severity of atopic dermatitis were found.

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About the authors

E E Varlamov

Allergology and clinical immunology department of the Research Clinical Institute of Pediatrics named after academician Y.E. Veltishev Moscow, Russia

O G Elisyutina

Email: el-olga@yandex.ru
Institute of Immunology Moscow, Russia

T V Vinogradova

Allergology and clinical immunology department of the Research Clinical Institute of Pediatrics named after academician Y.E. Veltishev Moscow, Russia

E S Fedenko

Institute of Immunology Moscow, Russia

A N Pampura

Allergology and clinical immunology department of the Research Clinical Institute of Pediatrics named after academician Y.E. Veltishev Moscow, Russia

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