MULTIPLE FACES OF BRONCHIAL ASTHMA – PHENOTYPES AND CLINICAL PATHOGENETIC VARIANTS

· RAJ №1-2012

Fedoseev G.B., Trofimov V.I., Shailieva L.O.,Eliseeva M.V., Kriakunov K.N.

M.V. Chernorutski Hospital Therapy Department; Saint-Petersburg State Pavlov Medical University

Key words: bronchial asthma, chronic obstructive pulmonary disease, phenotype, clinical pathogenetic variant

The article discusses heterogeneity of bronchial asthma from points of view of etiology, pathogenesis, clinical peculiarities and treatment approaches. The multiple faces of the disease are represented by different cellular phenotypes and clinical pathogenetic variants.

The article gives arguments for use of clinical pathogenetic variants in evaluation of the inflammation type and choice of personalized treatment. To evaluate cellular phenotypes and clinical pathogenetic variants complex investigations are to be performed in bronchial asthma patients.