Kolenchukova O.A., Smirnova S.V., Lapteva A.M. Immunologic reactivity and metabolic activity of blood lymphocytes associated with pathogenic form of allergic rhinosinusitis

· RAJ №4-2015

Kolenchukova O.A., Smirnova S.V., Lapteva A.M.

Scientific Research Institute of medical problems of the North, Krasnoyarsk, Russia

Key words: allergic rhinosinusitis, atopic rhinosinusitis, polypous rhinosinusitis, lymphocytes, cytokines,
enzymes

We had studied functional and metabolic activity of blood lymphocytes in allergic rhinosinusitis (ARS) –
atopic ARS and polypous rhinosinusitis (PRS). ARS is characterized by the increased level of CD25+ and
HLA- DR+ -lymphocytes in peripheral blood, IgA concentration in blood serum and sIgA in nasal secretion. At
the same time the deviation of immune response is directed towards Тh2 -lymphocytes and is accompanied by
high content of IL- 4 and IL- 6 in blood serum and nasal secretion. The activity of metabolic enzymes in blood
lymphocytes in ARS is caused by exasperation of plastic processes, intensification of lipoid catabolism and increase
of the speed of both anaerobic and aerobic oxidation. There are the following specific features of PRS: high level of
CD19+ -cells, activation of Th1- lymphocytes and high level of those cytokines, which they produce (IFN - and IL -2
in blood serum and nasal secretion). At the same time intensification of aerobic enzymes and lipoid metabolism
and decreasing of anaerobic processes and aminoacid metabolism in blood lymphocytes are in the progress.