Emelina Y.N., Tuzankina I.A., Zurochka A.V. Clinical efficacy of allergen-specific immunotherapy in children with combined forms of respiratory trees pollen allergy

· RAJ №3-2016

Emelina Y.N.1, 2, Tuzankina I.A.1, 2, Zurochka A.V.1, 3

1 Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences,
Ekaterinburg, Russia
2 Regional Children’s clinical Hospital No. 1, Ekaterinburg, Russia
3 South Ural State University (National Research University), Chelyabinsk, Russia

Key words: hay fever, allergic rhinoconjunctivitis, asthma, allergenspecific immunotherapy

Background. To evaluate the effectiveness of three courses of allergenspecific immunotherapy (ASIT) in children
with combined forms of respiratory pollen allergy.
Materials and methods. We observed 69 children aged 10,6±0,4 with combined forms of hay fever. All children
were randomized and divided into 3 subgroups who received allergen-specific immunotherapy (ASIT) with
Fostal, Staloral and water -salted mixed extracts of trees pollen. The comparison group consisted of 16 children
with combined forms of hay fever without ASIT. The effectiveness of treatment was assessed by dynamics of the
allergic rhino-conjunctivitis symptoms using a visual analogue scale and dynamics of the level of control over
the symptoms of bronchial asthma using standardized questionnaires – the Asthma Control Test.
Results. The first course of allergen-specific immunotherapy reduced the severity of rhinorrhea by 48%, nasal
congestion – by 45,1%, itching eyes – by 40,8%, nasal itching – by 30,6%, complete control of asthma symptoms
was achieved in 61,2%; ASIT reduced the likelihood of an uncontrolled flow of asthma in 17,6 times compared
with children who did not receive immunotherapy. After three courses of allergen-specific immunotherapy with
pollen allergens a decrease of the severity of allergic rhino-conjunctivitis symptoms and increase of the level of
asthma symptoms control in all subgroups was shown.