Demko I.V.1, 2, Sobko E.A.1, 2, Soloveva I.A.1, 2, Kraposhina A.Yu.1, Ishenko O.P.1, 2,
Gordeeva N.V.1, 2, Egorov S.A.1, Vturina S.S.1
1 Krasnoyarsk budgetary state medical university named after prof. V.F. Voino-Yasenetsky, ministry
of public health service of the Russian Federation
2 Krasnoyarsk State Budget Institution of Health «Krasnoyarsk Regional Hospital», Russia
Key words: bronchial asthma, cytokines, obesity, systemic inflammation
Background. To study the clinical and functional features in interrelationship between the level of proinflammatory
and antiinflammatory cytokines in young patients with bronchial asthma and alimentary obesity for
optimization of therapy.
Methods. 133 persons were examined: 93 patients with bronchial asthma were divided into 2 groups depending
on body weight index (BWI): the 1st group included patients with bronchial asthma with BWI less than 25 kg/m2,
the 2nd group included patients with bronchial asthma with BWI 30 kg/m2 and more. The group of control included
40 almost healthy persons. We studied external respiration function, cellular structure of the induced
sputum, the level of TNFa, IL-2, IL-4, IL-6, IL-15, Creactive protein in blood.
Results. The results of cytokines at patients with bronchial asthma depending on BWI out of an exacerbation of
the disease within the last 2 months. We found the signs of more significant systemic inflammation in the group
with obesity the increasing of the level of IL2, IL6, TNFa and Creactive protein in plasma was found.
Conclusion. We found that there was more sever course of bronchial asthma in young patients with obesity,
decreased external respiration functions, increased level of proinflammatory cytokines and proteins of acute
phase in peripheral blood.