ORCID ID: 0000-0003-3425-3463
Curriculum Vitae Mohamed H Shamji, PhD. CS. iFAAAAI
Current Positions
• Senior Lecturer in Immunology and Allergy at Imperial College London.
• Group leader (head), Immunomodulation and Tolerance Group, Allergy & Clinical Immunology, Imperial college London,
UK.
• Director, Immune Tolerance Network (ITN) Distributed Centre of Excellence for Allergy & Asthma at Imperial College
London.
International/National Positions & membership
• Chair, Scientific Programme Committee for the European Allergy and Clinical Immunology (EAACI) (2019-2021)
• Secretary, EAACI Immunotherapy Interest Group (2017-2019).
• Chair, EAACI Rhinallergy (RHINA) meeting (2019).
• Council member for the British Society of Allergy and Clinical Immunology (2016-2018)
• Member of the Collegium Internationale Allergologicum (CIA)
Qualifications
2010 PhD in Clinical Medicine Research/Allergy and Immunology, Imperial College London, UK
2005 Clinical Scientist fellowship training in Clinical Immunology, Chelsea & Westminster
Hospital NHS Foundation Trust in London, United Kingdom (UK)
2003 MSc Medical Immunology, St. George’s Hospital Medical School, University of London, UK
Teaching/Academic Experience
2016- NHLI- Basic and Clinical Allergy Course – Lead and Organiser
2015- Lecture, mark exam scripts and assess research projects on Molecular MSc course
2015- Lecture, mark exam scripts and assess research projects on Immunology MSc course
2011- Course leader and co-organiser, Respiratory Medicine BSc course, Allergy Module, Imperial College
London, UK
2011- Course co-organiser with Professor Stephen Durham, British Society of Allergy and Clinical Immunology Specialist Registrar
training day in Allergy. Imperial College London, UK
2013- Assess Early and Late Stage Reviews for NHLI PhD students
Selected Prizes and Fellowships
2018 PhARF Award 2018 (the most Prestigious Award in Allergy) in recognition to my contribution to allergen Immunotherapy
2018 Best postgraduate supervision Award 2018 at Imperial College London
2016 Travel grant – Alain de Weck Travel Grant, 31st Symposium of the Collegium International Allergologicum, Chalrstone, N
Carolina, USA, 2016 (March) $1250.
2015 Imperial College London President’s Award for Excellence in research at Imperial College London, UK.
2015 Outstanding abstract presentation at the European Academy, Allergology and Clinical Immunology (EAACI) congress 2015
(June), Barcelona, Spain
2012 Travel grant – Alain de Weck Travel Grant, 29th Symposium of the Collegium International Allergologicum, Jeju Island,
2012 (Oct) EURO 1,000.
2012 2 x Outstanding abstract presentations at the European Academy, Allergology and Clinical Immunology (EAACI) congress
2012 (June), Geneva, Switzerland
2011 Travel grant – World Allergy Congress in Cancun, Mexico, 2011 (Dec) $1000
2011 Outstanding World Allergy Organization (WAO) junior abstract at the World Allergy Congress, Cancun, Mexico, 2011
(Dec), best abstract award and oral presentation in the basic science category at the British Society of Allergy & Clinical
Immunology (BSACI) annual meeting (July) Nottingham, UK
2006-10 Best abstract presentation at the American Academy of Allergy, Asthma an Immunology (AAAAI) congress 2010 (Feb),
New Orleans, United States of America.
Best poster presentation at the European Academy, Allergology and Clinical Immunology (EAACI) congress 2009 (June),
Warsaw, Poland.
Best abstract award and oral presentation from Rhinitis, Sinusitis and Ocular Diseases (RSOD) interest section at the
annual American Academy of Allergy, Asthma and Immunology (AAAAI) congress 2007 (March), Philadelphia, United
States of America
2005-11 Awarded Postgraduate research (PhD) degree in allergy & clinical immunology funded by Biotechnology and Biological
Sciences Research Council (BBSRC) case studentships, a collaborative award in Science and Engineering in partnership
with Syngenta Ltd.
2000-5 Fellowship Award – 4year Clinical Scientist fellowship award funded by the Department of Health. Qualified as Clinical
Scientist in Clinical Immunology with certificate of attainment from the Association of Clinical Scientist (ACS).
* denotes equal contributions
Original Research Publications (2019)
1. Shamji, M.H.*, Thomsen, I.*, Layhadi, J.A., Kappen, J., Holtappels, G., Sahiner, U., Switzer, A., Kouser, L.,
Durham, S.R., Pabst, O., Bachert, C., Broad Immunglobulin G Repertoire in Chronic Rhinosinusitis with Nasal
Polyps regulates pro-inflammatory IgE responses. J Allergy Clin Immunol. 2019 Jun;143(6):2086-2094.e2. doi:
10.1016/j.jaci.2019.02.001. Epub 2019 Feb 11.
2. Shamji, M.H., Kappen J., Abubakar-Waziri, H., Zhang, J., Steveling, E., Watchman, S., Kouser, L., Eifan, A.,
Switzer, A., Varrichi, G., Marone, G., Couto-Francisco, N.C., Calderon, M., Durham, S.R. Nasal Allergen
Specific IgG4 antibodies with Neutralising Capacity to Block IgE-mediated Responses: A Novel biomarker of
Subcutaneous Grass Pollen Immunotherapy Evaluated in a Cross-Sectional Pilot Study. J Allergy Clin Immunol.
2019 Mar;143(3):1067-1076.
3. Sharif, H., Singh, I., Kouser, L., Mosges, R., Bonny, M., Karamani, A., Parkin, R.V., Bovy, N., Kishore, U., Robb,
A., Katotomichelakis, M., Holtappels, G., Derycke, L., Corazza, F., Von Frenckell, R., Wathelet, N., Duchateau,
J., Legon, T., Pirotton, S., Durham, S.R., Bachert, C., Shamji, M.H. Immunologic mechanisms of short-course
of Lolium Perenne Peptide Immunotherapy: A Randomized Double-Blind Placebo-Controlled Trial. J Allergy
Clin Immunol. 2019 Mar 5. pii: S0091-6749(19)30287-8. doi: 10.1016/j.jaci.2019.02.023.
4. Shamji MH, Layhadi JA, Achkova D, Kouser L, Perera-Webb A, Couto-Francisco NC, Parkin RV, Matsuoka T,
Scadding G, Ashton-Rickardt PG, Durham SR. Role of IL-35 in sublingual allergen immunotherapy. J Allergy
Clin Immunol. 2019 Mar;143(3):1131-1142.e4. doi: 10.1016/j.jaci.2018.06.041. Epub 2018 Jul 25.
5. Layhadi JA, Eguiluz-Gracia I, Shamji MH. Role of IL-35 in sublingual allergen immunotherapy. Curr Opin
Allergy Clin Immunol. 2019 Feb;19(1):12-17.
6. Skypala IJ, Cecchi L, Shamji MH, Scala E, Till S. Lipid Transfer Protein allergy in the United Kingdom:
Characterization and comparison with a matched Italian cohort. Allergy. 2019 Feb 14. doi: 10.1111/all.13747.
(In Press)
7. Rauber MM, Wu HK, Adams B, Pickert J, Bohle B, Shamji MH, Pfützner W, Möbs C. Birch pollen allergenspecific
immunotherapy with glutaraldehyde-modified allergoid induces IL-10 secretion and protective
antibody responses. Allergy. 2019 Aug;74(8):1575-1579. doi: 10.1111/all.13774. Epub 2019 Apr 11. No
abstract available.
Review Publications (2019)
8. Bousquet J, Pfaar O, Togias A, Schünemann HJ, Ansotegui I, Papadopoulos NG, Tsiligianni I, Agache I, Anto
JM, Bachert C, Bedbrook A, Bergmann KC, Bosnic-Anticevich S, Bosse I, Brozek J, Calderon M, Canonica
GW, Caraballo L, Cardona V, Casale T, Cecchi L, Chu DK, Costa E, Cruz AA, Czarlewski W, Durham SR, Du
Toit G, Dykewicz M, Ebisawa M, Fauquert JL, Fernandez-Rivas M, Fokkens WJ, Fonseca J, Fontaine JF, van
Wijk RG, Haahtela T, Halken S, Hellings PW, Ierodiakonou D, Iinuma T, Ivancevich JC, Jacobsen L, Jutel M,
Kaidashev I, Khaitov M, Kalayci O, Kleine Tebbe J, Klimek L, Kowalski ML, Kuna P, Kvedariene V, La Grutta
S, Larenas-Linemann D, Lau S, Laune D, Le L, Carlsen KL, Lourenço O, Malling HJ, Marien G, Menditto E,
Mercier G, Mullol J, Muraro A, O’Hehir R, Okamoto Y, Pajno GB, Park HS, Panzner P, Passalacqua G, Pham-
Thi N, Roberts G, Rolland C, Rosario N, Ryan D, Samolinski B, Sanchez-Borges M, Scadding G, Shamji MH,
Sheikh A, Sturm GJ, Todo Bom A, Toppila-Salmi S, Valentin-Rostan M, Valiulis A, Valovirta E, Ventura MT,
Wahn U, Walker S, Wallace D, Waserman S, Yorgancioglu A, Zuberbier T; ARIA Working Group. ARIA Care
pathways for allergen immunotherapy. Allergy. 2019 Apr 7. doi: 10.1111/all.13805.
9. Campo P, Eguiluz-Gracia I, Bogas G, Salas M, Plaza Serón C, Pérez N, Mayorga C, Torres MJ, Shamji MH,
Rondon C. Local allergic rhinitis: Implications for management. Clin Exp Allergy. 2019 Jan;49(1):6-16. doi:
10.1111/cea.13192. Epub 2018 Jul 5.
10. Eguiluz-Gracia I, Layhadi JA, Rondon C, Shamji MH. Mucosal IgE immune responses in respiratory diseases.
Curr Opin Pharmacol. 2019 Jun 17;46:100-107. doi: 10.1016/j.coph.2019.05.009. [Epub ahead of print]
11. Layhadi JA, Eguiluz-Gracia I, Shamji MH. Role of IL-35 in sublingual allergen immunotherapy. Curr
Opin Allergy Clin Immunol. 2019 Feb;19(1):12-17. doi: 10.1097/ACI.0000000000000499
12. Agache I, Annesi-Maesano I, Bonertz A, Branca F, Cant A, Fras Z, Ingenrieth F, Namazova-
Baranova L, Odemyr M, Spanevello A, Vieths S, Yorgancioglu A, Alvaro-Lozano M, Barber
Hernandez D, Chivato T, Del Giacco S, Diamant Z, Eguiluz-Gracia I, van Wijk RG, Gevaert P,
Graessel A, Hellings P, Hoffmann-Sommergruber K, Jutel M, Lau S, Lauerma A, Maria Olaguibel J,
O’Mahony L, Ozdemir C, Palomares O, Pfaar O, Sastre J, Scadding G, Schmidt-Weber C, Schmid-
Grendelmeier P, Shamji MH, Skypala I, Spinola M, Spranger O, Torres M, Vereda A, Bonini S.
Prioritizing research challenges and funding for allergy and asthma and the need for translational research-
The European Strategic Forum on Allergic Diseases. Allergy. 2019 May 9. doi: 10.1111/all.13856. [Epub ahead of
print]
Book Chapters
1. Shamji MH, Francis JN. Measurement of Allergen-Specific Inhibitory Antibody Activity. Methods Mol
Biol. 2019;2020:33-43. doi: 10.1007/978-1-4939-9591-2_3.
Original Research Publications (2018)
1. Rondón C, Eguíluz-Gracia I, Shamji MH, Layhadi JA, Salas M, Torres MJ, Campo P. IgE Test in Secretions of
Patients with Respiratory Allergy. Curr Allergy Asthma Rep. 2018 Oct 13;18(12):67.
2. Shamji, M.H., Layhadi, J.A., Achkova, D., Kouser, L., Perera-Webb, A., Couto-Francisco, N.C., Parkin, R.,
Matsuoka, T., Scadding, G., Ashton-Rickardt, P.G., Durham, S.R. Role of Interleukin-35 in sublingual allergen
immunotherapy. J Allergy Clin Immunol. 2018 Jul 25. (In press)
3. Renand, A*., Shamji, M.H*., Harris, K.M., Qin, T., Wambre, E., Scadding, G.W., Wurtzen, P.A., Till, S.J., Togias,
A., Nepom, G.T., Kwok, W.W., Durham, S.R. Synchronous immune alterations mirror clinical response during
allergen immunotherapy. J Allergy Clin Immunol. 2018 May;141(5):1750–1760.e1. (Editor’s Choice)
4. Shamji, M.H., Temblay, J.N., Cheng, W., Byrne, S.M., Macfarlane, E., Switzer, A.R., Francisco, N.D.C.,
Olexandra, F., Jacubczik, F., Durham, S.R., Ashton-Rickardt, P.G. Antiapoptotic serine protease inhibitors
contribute to survival of allergenic TH2 cells. J Allergy Clin Immunol. 2018 Aug;142(2):569-581.e5.
5. Mosges, R., Bachert, C., Panzner, P., Calderon, M.A., Haazen, L., Pirotton, S., Wathelet, N., Durham, S.R.,
Bonny, M.A., Legon, T., von Frenckell, R., Pfaar, O., Shamji, M.H. Short course of grass allergen peptides
immunotherapy over 3 weeks reduces seasonal symptoms in allergic rhinoconjunctivitis with/without asthma: A
randomized, multicenter, double-blind, placebo-controlled trial. Allergy. 2018;73(9):1842-50.
6. Mosges, R., Kasche, E.M., Raskopf, E., Singh, J., Sohlich, L., Astvatsatourov, A., Shah-Hosseini, K., Pirotton,
S., Haazen, L., Durham, S.R., Legon, T., Zadoyan, G., Shamji, M.H. A randomized, double-blind, placebocontrolled,
dose-finding trial with Lolium perenne peptide immunotherapy. Allergy. 2018 Apr;73(4):896-904.
7. Mosges, R., Koch, A.F., Raskopf, E., Singh, J., Shah-Hosseini, K., Astvatsatourov, A., Hauswald, B., Yarin, Y.,
Corazza, F., Haazen, L., Pirotton, S., Allekotte, S., Zadoyan, G., Legon, T., Durham, S.R., Shamji, M.H. Lolium
perenne peptide immunotherapy is well tolerated and elicits a protective B-cell response in seasonal allergic
rhinitis patients. Allergy. 2018 Jun;73(6):1254-1262.
8. Shamji, M.H., Ceuppens, J., Bachert, C., Hellings, P., Placier, G., Thirion, G., Bovy, N., Durham, S.R.,
Duchateau, J., Legon, T., Pirotton, S. Lolium perenne peptides for treatment of grass pollen allergy: A
randomized, double-blind, placebo-controlled clinical trial. J Allergy Clin Immunol. 2018 Jan;141(1):448-451.
9. Bahri, R., Custovic, A., Korosec, P., Tsoumani, M., Barron, M., Wu, J., Sayers, R., Weimann, A., Ruiz-Garcia,
M., Patel, N., Robb, A., Shamji, M.H., Fontanella, S., Silar, M., Mills, E.N.C., Simpson, A., Turner, P.J., Bulfone-
Paus, S. Mast cell activation test in the diagnosis of allergic disease and anaphylaxis. J Allergy Clin Immunol.
2018 Aug;142(2):485-496.e16.
10. Bulfone-Paus, S., Bahri, R., Shamji, M.H., Custovic, A., Turner, P.J. Reply. J Allergy Clin Immunol. 2018.
EAACI White Paper publication (2018)
11. Schmidt-Weber*, C.B., Shamji, M.H*. The innate Immune Response. EAACI White Paper on Research and
Innovation. 2018;B1:25-26.
Review Publications (2018)
12. Pfaar, O., Bonini, S., Cardona, V., Demoly, P., Jakob, T., Jutel, M., Kleine-Tebbe, J., Klimek, L., Klysner, S.,
Kopp, M. V, Kuna, P., Larche, M., Muraro, A., Schmidt-Weber, C.B., Shamji, M.H., Simonsen, K., Somoza, C.,
Valovirta, E., Zieglmayer, P., Zuberbier, T., Wahn, U. Perspectives in allergen immunotherapy: 2017 and
beyond. Allergy. 2018 Jan;73 Suppl 104:5-23.
13. Campo, P., Eguiluz-Gracia, I., Bogas, G., Salas, M., Plaza Seron, C., Perez, N., Mayorga, C., Torres, M.J.,
Shamji, M.H., Rondon, C., 2018. Local allergic rhinitis: Implications for management. Clin Exp Allergy. 2018.
(In press)
14. Kortekaas Krohn, I., Shikhagaie, M.M., Golebski, K., Bernink, J.H., Breynaert, C., Creyns, B., Diamant, Z.,
Fokkens, W.J., Gevaert, P., Hellings, P., Hendriks, R.W., Klimek, L., Mjosberg, J., Morita, H., Ogg, G.S.,
O’Mahony, L., Schwarze, J., Seys, S.F., Shamji, M.H., Bal, S.M. Emerging roles of innate lymphoid cells in
inflammatory diseases: Clinical implications. Allergy. 2018 Apr;73(4):837-850.
15. Rondon, C., Eguíluz-Gracia, I., Shamji, M.H., Layhadi, J.A., Salas, M., Torres, M.J., Campo, P. IgE test in
secretions of patients with respiratory allergy. Curr Allergy Asthma Rep. 2018;18(12):67.
Original Research Publications (2017)
16. Scadding, G.W*., Calderon, M.A*., Shamji, M.H*., Eifan, A.O., Penagos, M., Dumitru, F., Sever, M.L., Bahnson,
H.T., Lawson, K., Harris, K.M., Plough, A.G., Panza, J.L., Qin, T., Lim, N., Tchao, N.K., Togias, A., Durham,
S.R. Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Response to
Allergen Challenge at 3 Years Among Patients With Moderate to Severe Seasonal Allergic Rhinitis: The GRASS
Randomized Clinical Trial. JAMA. 2017 Feb 14;317(6):615-625.
17. Qaseem, A.S., Singh, I., Pathan, A.A., Layhadi, J.A., Parkin, R., Alexandra, F., Durham, S.R., Kishore, U.,
Shamji, M.H. A Recombinant Fragment of Human Surfactant Protein D Suppresses Basophil Activation and THelper
Type 2 and B-Cell Responses in Grass Pollen-induced Allergic Inflammation. Am J Respir Crit Care
Med. 2017 Dec 15;196(12):1526-1534.
18. Slovick, A., Douiri, A., Muir, R., Guerra, A., Tsioulos, K., Hay, E., Lam, E.P.S., Kelly, J., Peacock, J.L., Ying, S.,
Shamji, M.H., Cousins, D.J., Durham, S.R., Till, S.J. Intradermal grass pollen immunotherapy increases TH2
and IgE responses and worsens respiratory allergic symptoms. J Allergy Clin Immunol. 2017 Jun;139(6):1830-
1839.e13.
19. Korosec, P., Turner, P.J., Silar, M., Kopac, P., Kosnik, M., Gibbs, B.F., Shamji, M.H., Custovic, A., Rijavec, M.,
2017. Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis. J Allergy Clin Immunol. 2017
Sep;140(3):750-758.e15.
EAACI Positions Paper publication (2017)
20. Shamji, M.H., Kappen, J.H., Akdis, M., Jensen-Jarolim, E., Knol, E.F., Kleine-Tebbe, J., Bohle, B., Chaker,
A.M., Till, S.J., Valenta, R., Poulsen, L.K., Calderon, M.A., Demoly, P., Pfaar, O., Jacobsen, L., Durham, S.R.,
Schmidt-Weber, C.B. Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic
rhinoconjunctivitis and allergic asthma: an EAACI Position Paper. Allergy. 2017 Aug;72(8):1156-1173.
Review Publications (2017)
21. Kappen, J.H., Durham, S.R., Veen, H.I., Shamji, M.H. Applications and mechanisms of immunotherapy in
allergic rhinitis and asthma. Ther Adv Respir Dis. 2017 Jan;11(1):73-86.
22. Kouser, L., Kappen, J., Walton, R.P., Shamji, M.H. Update on Biomarkers to Monitor Clinical Efficacy Response
During and Post Treatment in Allergen Immunotherapy. Curr Treat Options Allergy. 2017;4(1):43-53.
23. Shamji, M.H., Durham, S.R. Mechanisms of allergen immunotherapy for inhaled allergens and predictive
biomarkers. J Allergy Clin Immunol. 2017 Dec;140(6):1485-1498.
Original Research Publications (2016)
24. Chaker, A.M., Shamji, M.H., Dumitru, F.A., Calderon, M.A., Scadding, G.W., Makatsori, M., Jones, I., He, Q.A.,
Subramanian, K.K., Arm, J.P., Durham, S.R., Schmidt-Weber, C.B. Short-term subcutaneous grass pollen
immunotherapy under the umbrella of anti-IL-4: A randomized controlled trial. J Allergy Clin Immunol. 2016
Feb;137(2):452-461.e9.
25. Gadermaier, E., James, L.K., Shamji, M.H., Blatt, K., Fauland, K., Zieglmayer, P., Garmatiuk, T., Focke-Tejkl,
M., Villalba, M., Beavil, R., Keller, W., Valent, P., Durham, S.R., Gould, H.J., Flicker, S., Valenta, R. Epitope
specificity determines cross-protection of a SIT-induced IgG4 antibody. Allergy. 2016 Jan;71(1):36-46.
26. Pednekar, L., Pathan, A.A., Paudyal, B., Tsolaki, A.G., Kaur, A., Abozaid, S.M., Kouser, L., Khan, H.A.,
Peerschke, E.I., Shamji, M.H., Stenbeck, G., Ghebrehiwet, B., Kishore, U. Analysis of the Interaction between
Globular Head Modules of Human C1q and Its Candidate Receptor gC1qR. Front Immunol. 2016 Dec 13;7:567.
27. Pondman, K.M., Tsolaki, A.G., Paudyal, B., Shamji, M.H., Switzer, A., Pathan, A.A., Abozaid, S.M., Ten Haken,
B., Stenbeck, G., Sim, R.B., Kishore, U. Complement Deposition on Nanoparticles Can Modulate Immune
Responses by Macrophage, B and T Cells. J Biomed Nanotechnol. 2016 Jan;12(1):197-216.
28. Slovick, A., Douiri, A., Muir, R., Guerra, A., Tsioulos, K., Haye, E., Lam, E.P.S., Kelly, J., Peacock, J.L., Ying,
S., Shamji, M.H., Cousins, D.J., Durham, S.R., Till, S.J. A randomised placebo-controlled trial investigating
efficacy and mechanisms of low-dose intradermal allergen immunotherapy in treatment of seasonal allergic
rhinitis. NIHR publications. Southampton (UK). 2016 Dec.
Review Publications (2016)
29. Varricchi, G., Harker, J., Borriello, F., Marone, G., Durham, S.R., Shamji, M.H. T follicular helper (Tfh) cells in
normal immune responses and in allergic disorders. Allergy. 2016 Aug;71(8):1086-94.
30. Calderon, M.A., Demoly, P., Casale, T., Akdis, C.A., Bachert, C., Bewick, M., Bilo, B.M., Bohle, B., Bonini, S.,
Bush, A., Caimmi, D.P., Canonica, G.W., Cardona, V., Chiriac, A.M., Cox, L., Custovic, A., De Blay, F., Devillier,
P., Didier, A., Di Lorenzo, G., Du Toit, G., Durham, S.R., Eng, P., Fiocchi, A., Fox, A.T., van Wijk, R.G., Gomez,
R.M., Haathela, T., Halken, S., Hellings, P.W., Jacobsen, L., Just, J., Tanno, L.K., Kleine-Tebbe, J., Klimek, L.,
Knol, E.F., Kuna, P., Larenas-Linnemann, D.E., Linneberg, A., Matricardi, M., Malling, H.J., Moesges, R., Mullol,
J., Muraro, A., Papadopoulos, N., Passalacqua, G., Pastorello, E., Pfaar, O., Price, D., Del Rio, P.R., Rueff, R.,
Samolinski, B., Scadding, G.K., Senti, G., Shamji, M.H., Sheikh, A., Sisul, J.C., Sole, D., Sturm, G.J., Tabar,
A., Van Ree, R., Ventura, M.T., Vidal, C., Varga, E.M., Worm, M., Zuberbier, T., Bousquet, J. Allergy
immunotherapy across the life cycle to promote active and healthy ageing: from research to policies: An
AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation
Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases
(GARD), a World Health Organization GARD research demonstration project. Clin Transl Allergy. 2016 Nov
23;6:41.
Original Research Publications (2015)
31. Shamji, M.H., Layhadi, J.A., Scadding, G.W., Cheung, D.K.M., Calderon, M.A., Turka, L.A., Phippard, D.,
Durham, S.R. Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response.
J Allergy Clin Immunol. 2015 Apr;135(4):913-21.e9.
32. Shamji, M.H., Bellido, V., Scadding, G.W., Layhadi, J.A., Cheung, D.K.M., Calderon, M.A., Asare, A., Gao, Z.,
Turka, L.A., Tchao, N., Togias, A., Phippard, D., Durham, S.R. Effector cell signature in peripheral blood
following nasal allergen challenge in grass pollen allergic individuals. Allergy. 2015 Feb;70(2):171-9.
33. Scadding, G.W., Eifan, A., Penagos, M., Dumitru, A., Switzer, A., McMahon, O., Phippard, D., Togias, A.,
Durham, S.R., Shamji, M.H. Local and systemic effects of cat allergen nasal provocation. Clin Exp Allergy.
2015 Mar;45(3):613-23.
34. Scadding, G.W., Eifan, A.O., Lao-Araya, M., Penagos, M., Poon, S.Y., Steveling, E., Yan, R., Switzer, A.,
Phippard, D., Togias, A., Shamji, M.H., Durham, S.R. Effect of grass pollen immunotherapy on clinical and local
immune response to nasal allergen challenge. Allergy. 2015 Jun;70(6):689-96.
35. Shamji, M.H., Durham, S.R. Reply: To PMID 25457150. J Allergy Clin Immunol. 2015 Apr;135(4):1089-90.
36. Santos, A.F., James, L.K., Bahnson, H.T., Shamji, M.H., Couto-Francisco, N.C., Islam, S., Houghton, S., Clark,
A.T., Stephens, A., Turcanu, V., Durham, S.R., Gould, H.J., Lack, G. IgG4 inhibits peanut-induced basophil and
mast cell activation in peanut-tolerant children sensitized to peanut major allergens. J Allergy Clin Immunol.
2015 May;135(5):1249-56.
37. Steveling, E.H., Lao-Araya, M., Koulias, C., Scadding, G., Eifan, A., James, L.K., Dumitru, A., Penagos, M.,
Calderon, M., Andersen, P.S., Shamji, M., Durham, S.R. Protocol for a randomised, double-blind, placebocontrolled
study of grass allergen immunotherapy tablet for seasonal allergic rhinitis: time course of nasal,
cutaneous and immunological outcomes. Clin Transl Allergy. 2015 Dec 17;5:43.
38. Dodev, T.S., Bowen, H., Shamji, M.H., Bax, H.J., Beavil, A.J., McDonnell, J.M., Durham, S.R., Sutton, B.J.,
Gould, H.J., James, L.K. Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but
different class. Allergy. 2015 Jun;70(6):720-4.
39. Pondman, K.M., Pednekar, L., Paudyal, B., Tsolaki, A.G., Kouser, L., Khan, H.A., Shamji, M.H., Ten Haken,
B., Stenbeck, G., Sim, R.B., Kishore, U. Innate immune humoral factors, C1q and factor H, with differential
pattern recognition properties, alter macrophage response to carbon nanotubes. Nanomedicine. 2015
Nov;11(8):2109-18.
Original Research Publications (2014)
40. Lao-Araya, M., Steveling, E., Scadding, G.W., Durham, S.R., Shamji, M.H. Seasonal increases in peripheral
innate lymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy. J Allergy Clin Immunol.
2014 Nov;134(5):1193-5.e4. (Editor’s Choice)
41. Wood, R.A., Togias, A., Wildfire, J., Visness, C.M., Matsui, E.C., Gruchalla, R., Hershey, G., Liu, A.H.,
O’Connor, G.T., Pongracic, J.A., Zoratti, E., Little, F., Granada, M., Kennedy, S., Durham, S.R., Shamji, M.H.,
Busse, W.W. Development of cockroach immunotherapy by the Inner-City Asthma Consortium. J Allergy Clin
Immunol. 2014 Mar;133(3):846-52.e6.
42. Vickery, B.P., Scurlock, A.M., Kulis, M., Steele, P.H., Kamilaris, J., Berglund, J.P., Burk, C., Hiegel, A., Carlisle,
S., Christie, L., Perry, T.T., Pesek, R.D., Sheikh, S., Virkud, Y., Smith, P.B., Shamji, M.H., Durham, S.R., Jones,
S.M., Burks, A.W. Sustained unresponsiveness to peanut in subjects who have completed peanut oral
immunotherapy. J Allergy Clin Immunol. 2014 Feb;133(2):468-75.
43. Turner, P.J., Mehr, S., Sayers, R., Wong, M., Shamji, M.H., Campbell, D.E., Mills, E.N. Loss of allergenic
proteins during boiling explains tolerance to boiled peanut in peanut allergy. J Allergy Clin Immunol. 2014
Sep;134(3):751-3.
44. Pillai, P., Fang, C., Chan, Y.-C., Shamji, M.H., Harper, C., Wu, S.-Y., Ohm-Laursen, L., Durham, S.R., Menzies-
Gow, A., Rajakulasingam, R.K., Ying, S., Corrigan, C.J., Gould, H.J. Allergen-specific IgE is not detectable in
the bronchial mucosa of nonatopic asthmatic patients. J Allergy Clin Immunol. 2014 Jun;133(6):1770-2.e11.
45. Jones, M., Jeal, H., Schofield, S., Harris, J.M., Shamji, M.H., Francis, J.N., Durham, S.R., Cullinan, P. Ratspecific
IgG and IgG(4) antibodies associated with inhibition of IgE-allergen complex binding in laboratory
animal workers. Occup Environ Med. 2014 Sep;71(9):619-23.
Review Publications (2014)
46. Shamji, M.H. Mechanisms of Allergen-Specific Sublingual Immunotherapy and the Use of Biological Markers
in Allergic Rhinitis. Curr Treat Options Allergy. 2014 Mar;1(1):1-13.
Original Research Publications (2013)
47. Shamji, M.H., Francis, J.N., Wurtzen, P.A., Lund, K., Durham, S.R., Till, S.J. Cell-free detection of allergen-IgE
cross-linking with immobilized phase CD23: inhibition by blocking antibody responses after immunotherapy. J
Allergy Clin Immunol. 2013 Oct;132(4):1003-5.e1-4.
48. Shamji, M.H., Ljorring, C., Wurtzen, P.A. Predictive biomarkers of clinical efficacy of allergen-specific
immunotherapy: how to proceed. Immunotherapy. 2013 Mar;5(3):203-6.
49. Marth, K., Breyer, I., Focke-Tejkl, M., Blatt, K., Shamji, M.H., Layhadi, J., Gieras, A., Swoboda, I., Zafred, D.,
Keller, W., Valent, P., Durham, S.R., Valenta, R. A nonallergenic birch pollen allergy vaccine consisting of
hepatitis PreS-fused Bet v 1 peptides focuses blocking IgG toward IgE epitopes and shifts immune responses
to a tolerogenic and Th1 phenotype. J Immunol. 2013 Apr 1;190(7):3068-78.
50. Slovick, A., Douiri, A., Kelly, J., Guerra, A., Muir, R., Tsioulos, K., Murphy, C., Shamji, M.H., Ying, S., Durham,
S.R., Till, S.J. Protocol for a double-blind randomised controlled trial of low dose intradermal grass pollen
immunotherapy versus a histamine control on symptoms and medication use in adults with seasonal allergic
rhinitis (PollenLITE). Clin Transl Allergy. 2013 Aug 21;3(1):27.
51. Varga, E.-M., Kausar, F., Aberer, W., Zach, M., Eber, E., Durham, S.R., Shamji, M.H. Tolerant beekeepers
display venom-specific functional IgG4 antibodies in the absence of specific IgE. J Allergy Clin Immunol. 2013
May;131(5):1419-21.
Review Publications (2013)
52. Durham, S.R., Scadding, G.W., Phippard, D., Wurtzen, P.A., Shamji, M.H. Biomarkers of tolerance in response
to allergen immunotherapy. Arb Paul Ehrlich Inst Bundesinstitut Impfstoffe Biomed Arzneim Langen Hess.
2013;97:75-81.
53. Matsuoka, T., Shamji, M.H., Durham, S.R. Allergen immunotherapy and tolerance. Allergol Int. 2013
Dec;62(4):403-13.
54. Qaseem, A.S., Sonar, S., Mahajan, L., Madan, T., Sorensen, G.L., Shamji, M.H., Kishore, U. Linking surfactant
protein SP-D and IL-13: implications in asthma and allergy. Mol Immunol. 2013 May;54(1):98-107.
Original Research Publications (2012)
55. Shamji, M.H., Ljørring, C., Francis, J.N., A Calderon, M., Larché, M., Kimber, I., Frew, A.J., Ipsen, H., Lund, K.,
Würtzen, P.A., Durham, S.R. Functional rather than immunoreactive levels of IgG4 correlate closely with clinical
response to grass pollen immunotherapy. Allergy. 2012 Feb;67(2):217-26.
56. Rotiroti, G., Shamji, M., Durham, S.R., Till, S.J. Repeated low-dose intradermal allergen injection suppresses
allergen-induced cutaneous late responses. J Allergy Clin Immunol. 2012 Oct;130(4):918-24.e1.
57. James, L.K., Bowen, H., Calvert, R.A., Dodev, T.S., Shamji, M.H., Beavil, A.J., McDonnell, J.M., Durham, S.R.,
Gould, H.J. Allergen specificity of IgG(4)-expressing B cells in patients with grass pollen allergy undergoing immunotherapy. J Allergy Clin Immunol. 2012 Sep;130(3):663-670.e3.
58. Herranz, F., Schmidt-Weber, C.B., Shamji, M.H., Narkus, A., Ruiz-Cabello, J., Vilar, R. Superparamagnetic iron oxide nanoparticles conjugated to a grass pollen allergen and an optical probe. Contrast Media Mol Imaging. 2012 Jul-Aug;7(4):435-9. Original Research Publications (2011)
59. James, L.K*., Shamji, M.H*., Walker, S.M., Wilson, D.R., Wachholz, P.A., Francis, J.N., Jacobson, M.R., Kimber, I., Till, S.J., Durham, S.R. Long term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies. J Allergy Clin Immunol. 2011 Feb;127(2):509-516.e1-5.
60. Dumitru, A.F., Shamji, M., Wagenmann, M., Hindersin, S., Scheckenbach, K., Greve, J., Klenzner, T., Hess, L., Nebel, S., Zimmermann, C., Zahner, C., Schmidt-Weber, C.B., Chaker, A.M. Petasol butenoate complex (Ze 339) relieves allergic rhinitis-induced nasal obstruction more effectively than desloratadine. J Allergy Clin Immunol. 2011 Jun;127(6):1515-21.e6. Review Publications (2011)
61. Shamji, M.H., Durham, S.R. Mechanisms of immunotherapy to aeroallergens. Clin Exp Allergy. 2011 Sep;41(9):1235-46.
62. Shamji, M.H., James, L.K., Durham, S.R. Serum immunologic markers for monitoring allergen-specific immunotherapy. Immunol Allergy Clin North Am. 2011 May;31(2):311-23, x.
63. Eifan, A.O., Shamji, M.H., Durham, S.R. Long-term clinical and immunological effects of allergen
immunotherapy. Curr Opin Allergy Clin Immunol. 2011 Dec;11(6):586-93. Original Research Publications (2010)
64. Pree, I*., Shamji, M.H*., Kimber, I., Valenta, R., Durham, S.R., Niederberger, V. Inhibition of CD23-dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules. Clin Exp Allergy. 2010 Sep;40(9):1346-52.
65. Scadding, G.W*., Shamji, M.H*., Jacobson, M.R., Lee, D.I., Wilson, D., Lima, M.T., Pitkin, L., Pilette, C., Nouri-Aria, K., Durham, S.R. Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells. Clin Exp Allergy. 2010 Apr;40(4):598-606. Original Research Publications (2008)
66. Steel, A., John, L., Shamji, M.H., Henderson, D.C., Gotch, F.M., Gazzard, B.G., Kelleher, P. CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy. HIV Med. 2008 Feb;9(2):118-25. Original Research Publications (2007)
67. Steel, A., Cox, A.E., Shamji, M.H., John, L., Nelson, M., Henderson, D.C., Gotch, F.M., Gazzard, B.G., Kelleher, P. HIV-1 viral replication below 50 copies/ml in patients on antiretroviral therapy is not associated with CD8+ Tcell activation. Antivir Ther. 2007;12(6):971-5. Original Research Publications (2006)
68. Shamji, M.H., Wilcock, L.K., Wachholz, P.A., Dearman, R.J., Kimber, I., Wurtzen, P.A., Larche, M., Durham, S.R., Francis, J.N. The IgE facilitated allergen binding (FAB) assay: validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses. J Immunol Methods. 2006 Dec 20;317(1-2):71-9. Book Chapters
1. Sahiner, U.M., Kappen, J.H., Yildirim, O., Shamji, M.H. (2018). Chapter 12. Clinical Markers to AIT Response. Immunotherapies for Allergic Disease. (Accepted). Edited by L. Cox. Publisher: Elsevier
2. Shamji, M.H., Till, J.S., Durham, S.R. (Feb 2014). Immunological Responses to Subcutaneous Allergen Immunotherapy. Allergens and Allergen Immunotherapy. Publisher: CRC Press, Taylor and Francis Group
3. Shamji, M.H., Francis, J.N. Measurements of Allergen-Specific Inhibitory Antibody Activity by Facilitated Antigen Binding (FAB) and Enzyme Linked Facilitated Antigen Binding (ELIFAB) Assays. Methods in Molecular Medicine: Allergy Methods and Protocols. Edited by: M.G. Jones and P. Lympany. Publisher: Humana Press Inc., Totowa, NJ 1.
Conference proceedings
1. Shamji, M.H., Scadding, G.W., Calderon, M.A., Phippard, D., Durham, S.R. Effects of Grass Pollen Immunotherapy
on Peripheral Innate Lymphoid Type 2 cells (30th Symposium of the Collegium Internationale Allergologicum
Petersberg, Germany-2014).
2. Durham, S.R., Abubakar-Waziri, A., Steveling, E., Varricci, G., Parkin, R.V., Shamji, M.H. Allergen Immunotherapy
is associated with the induction of Nasal and Serum immunereactive and inhibitory IgG4 antibodies in grass-pollen
induced seasonal allergic rhinitis. (30th Symposium of the Collegium Internationale Allergologicum Petersberg,
Germany-2014)
3. Varricchi, G., Parkin, R.V., Steveling, E., Marone, G., Durham, S.R., Shamji, M.H. Interleukin-21 induced IgEsythesis
in memory B cells: A role for T follicular helper cells in Seasonal Allergic Rhinitis. (30th Symposium of the
Collegium Internationale Allergologicum Petersberg, Germany-2014).
4. Shamji, M.H., Durham, S.R. Non-IgE blocking antibodies: Surrogate biomarkers of clinical efficacy to grass pollen
immunotherapy (28th Symposium of the Collegium Internationale Allergologicum, Ischia, Italy-2010).
5. Shamji, M.H., Layhadi, J.A., Achkova, D., Scadding, G.W., Phippard, D., Durham, S.R. IL-35+CD4+CD25+Foxp3-
regulatory T cells suppress Th2 responses and are induced following grass pollen-specific sublingual
immunotherapy (29th Symposium of the Collegium Internationale Allergologicum Jeju island, South Korea-2012).
6. Durham, S.R., Bellido, V., Scadding, G.W., Layhadi, J.A., Calderon, M., Togias, A., Tchao, N., Turka, L., Phippard,
D., Shamji, M.H. Effects of nasal allergen challenge on T effector cell signature in peripheral blood in patients with
grass pollen-induced rhinitis. (29th Symposium of the Collegium Internationale Allergologicum Jeju island, South
Korea-2012).
7. Shamji, M.H., Scadding, G.W., Calderon, M., Phippard, D., Durham, S.R. Monitoring Basophil Responsiveness
Following Allergen Immunotherapy. 29th Symposium of the Collegium Internationale Allergologicum Jeju island,
South Korea-2010).
Conferences peer – reviewed abstracts
2018
1. Kirtland M, Tsitoura D, Durham SR, Shamji MH. An in vitro assay to screen Toll-like Receptor agonists as potential
adjuvants in allergen immunotherapy. BRITISH SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual
Meeting; 2018.
2. Ntavli E, Sahiner U, Layhadi J, Robb AO, Ruiz-Garcia M, Skypala I, Mills C, Durham SR, Turner P, Shamji MH.
Group 2 Innate Lymphoid Cells (ILC2s) contribute to the pathophysiology of Peanut. BRITISH SOCIETY OF
ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2018.
3. Layhadi JA, Achkova D, Kouser L, Perera-Webb A, Couto Francisco N, Parkin R, Matsuoka T, Scadding G, Ashton-
Rickardt P, Durham SR, Shamji MH. Interleukin-35 regulates type II-mediated responses elicited by innate lymphoid
cells in allergic diseases. BRITISH SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2018.
4. Singh I, Sharif H, Kouser L, Karamani A, Kishore U, Gabriele H, Derycke L, von Frenckell R, Wathelet N, Duchateau
J, Legon T, Pirotton S, Mösges R, Durham SR, Bachert C, Shamji MH. IL-35+ T regulatory cells (iTR35) induces
IL-10-producing B regulatory cells and blocking antibodies in short course of Lolium Perenne Peptide (LPP)
Immunotherapy. BRITISH SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2018.
5. Hug O, Singh I, Robb A, Yildirim O, Durham S, Shamji MH. IL-35 induces IL-10 producing Regulatory B cells in
immunotherapy treated patients. BRITISH SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual
Meeting; 2018.
6. Tang J, Singh I, Parkin R, Wang C, Kostic A, DurhamSR , Radin A, Shamji MH. Clinical and Immunologic Effects
of a Single Dose of Anti-Fel d 1-IgG4 monoclonal antibodies in Cat Allergic Individuals: A Double Blind Randomized
Placebo-Controlled Study. BRITISH SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting;
2018.
7. Stranzl T, Lundegaard C, Ohashi-Doi K, Shamji MH, Andersen PS. A machine learning approach to evaluate IgE
and IgG4 responses as patient-specific measure of exposure to sublingual allergen immunotherapy. EUROPEAN
ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2018: John Wiley & Sons, Inc. Allergy
73, 336-337.
8. Layhadi JA, Matsuoka T, Scadding G, Ashton-Rickardt P, Durhma SR, Shamji MH. Interleukin (IL)-35 producing
T regulatory cells (iTR35) suppresses type II innate lymphoid cell (ILC2) and T helper 2 (Th2) cell function and are
induced following grass pollen immunotherapy. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL
IMMUNOLOGY Annual Meeting; 2018: John Wiley & Sons, Inc. Allergy 73, 43.
9. Moesges R, Demoly P, Lehmacher W, Durham S, Shamji M, Pirotton S, Haazen L, Calderon M. Safety of a 3-
week allergen immunotherapy course with grass pollen peptides: A randomised double-blind placebo-controlled
trial. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2018: John Wiley
& Sons, Inc. Allergy 73, 471.
10. Mosges R, Bachert C, Creticos PS, Cox L, Durham SR, Pirotton S, Bonny, MA, Legon T, Haazen L, Shamji MH.
Quality of Life during the hay fever season after short-course subcutaneous immunotherapy with Lolium perenne
peptides (LPP) in grass pollen related rhinoconjunctivitis: A RDBPCT. AMERICAN ACADEMY OF ALLERGY,
ASTHMA AND IMMUNOLOGY Annual Meeting; 2018; J Allergy and Clinical Immunology 141(2):AB291.
11. Singh I, Sharif H, Kouser L, Karamani A, Kishore U, Holtappels G, Derycke L, Von Frenckell R, Wathelet N,
Duchateau J, Legon T, Pirotton S, Mosges R, Durham SR, Bachert C, Shamji MH. Short Course of Lolium Perenne
Peptides (LPP) Immunotherapy Induces IL-35+ T Regulatory Cells (iTr35) that Promote B Regulatory Cells (Bregs)
and Blocking Antibodies. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting;
2018; J Allergy and Clinical Immunology 141(2):AB122.
12. Sharif H, Karamani A, Parkin R, Kouser L, Singh I, Robb A, Holtappels G, Derycke L, Von Frenckell R, Wathelet
N, Duchateau J, Legon T, Pirotton S, Mosges R, Durham SR, Bachert C, Shamji MH. Short Course of Lolium
Perenne Peptides (LPP) Immunotherapy Deletes Circulating IL-4+ IL-21+ T follicular helper cells and Induces
FoxP3+ T follicular regulatory cells: A Randomized Controlled Trial. AMERICAN ACADEMY OF ALLERGY,
ASTHMA AND IMMUNOLOGY Annual Meeting; 2018; J Allergy and Clinical Immunology 141(2):AB197.
13. Eifan A, Scadding G, Calderon M, Shamji M, Penagos M, Alder-Wurtzen P, Sever M, Bahnson H, Lawson , Harris
K, Qin T, Lim N, Plough A, Tchao N, Togias A, Durham S. Relationship between response to grass pollen nasal
allergen challenge and seasonal symptoms and the effect of treatment compliance. BRITISH SOCIETY OF
ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2017: WILEY-BLACKWELL 111 RIVER ST,
HOBOKEN 07030-5774, NJ USA. Clinical and Experimental Allergy 47(12): 1686-1687.
14. Kim EH, Sicherer SH, Wood RA, Bidslev-Jensen C, Hamilton RG, Shamji MH, Van Twuijver E, Opstelten D, De
Kam PJ. Safety and tolerability of subcutaneous immunotherapy (SCIT) with a modified peanut extract in peanutallergic
adults, adolescents and children. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY
Annual Meeting; 2017: John Wiley & Sons, Inc. Allergy 72: 738-739.
15. Bahri R, Robb A, Shamji MH, Custovic A, Turner PJ, Bulfone-Paus S. Mast cell activation test distinguishes between
sensitisation and clinical reactivity with improved diagnostic characteristics compared to other diagnostic techniques
including basophil activation. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual
Meeting; 2017: John Wiley & Sons, Inc. Allergy 72: 139-140.
16. Skypala IJ, Cecchi L, Shamji MH, Scala E, Till S. Lipid transfer protein allergy in UK adults-characterisation and
comparison to adults with pollen-food syndrome. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL
IMMUNOLOGY Annual Meeting; 2017: John Wiley & Sons, Inc. Allergy 72: 29.
17. Durham S, Schwabe C, Robson R, Emanuelsson C, Shamji M, Singh D, Man T, Clarke G, Zhong S, Kamal M,
Newell D, Stahl N, Yancopoulos GD, Kostic A. A randomized clinical trial of passive immunotherapy with singledose
anti-Fel d1 monoclonal antibodies REGN 1908-1909 in cat-induced rhinoconjunctivitis: exploratory efficacy
endpoints, safety. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2017:
John Wiley & Sons, Inc. Allergy 72: 64-65.
18. Turner PJ, Robb A, Gibbs BF, Shamji MH, Silar M, Custovic A, Korosec P. Peripheral basopenia during
peanutinduced allergic reactions-a protective response? EUROPEAN ACADEMY OF ALLERGY AND CLINICAL
IMMUNOLOGY Annual Meeting; 2017: John Wiley & Sons, Inc. Allergy 72: 131-131.
19. Shamji MH, Mosges R, Bonny M, Bovy N, Karamani A, Parkin R, Katotomichelakis M, Holtappels G, Derycke L,
Corazza F, Von Frenckell R, Duchateau J, Legon T, Pirotton S, Durham SR, Bachert C. Short course treatment of
subcutaneous peptide hydrolysate from lolium perenne (LPP) suppresses basophil responses and induces iggassociated
blocking antibodies: a RDPCT. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY
Annual Meeting; 2017: John Wiley & Sons, Inc. Allergy 72: 143-143.
20. Moesges R, Panzner P, Pfaar O, Thomson M, Haazen L, Bonny M, Von Frenckell R, Pirotton S, Legon T, Durham
SR, Shamji MH, Bachert C. Efficacy of a 3-week subcutaneous immunotherapy course in patients with grass polleninduced
rhinoconjunctivitis: Results of a phase-3 study. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL
IMMUNOLOGY Annual Meeting; 2017: John Wiley & Sons, Inc. Allergy 72: 374-374.
21. Scadding GW, Eifan AO, Calderon MA, Shamji MH, Penagos M, Wurtzen PA, Sever ML, Bahnson HT, Lawson K,
Harris KM, Qin T, Lim N, Plough A, Tchao NK, Togias A, Durham SR. Response to Nasal Challenge Correlates
with Seasonal Outcomes during Grass Pollen Immunotherapy with Either Subcutaneous or Sublingual
Immunotherapy. . AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2017; J
Allergy and Clinical Immunology 139(2):AB385.
22. Singh I, Qaseem A, Pathan A, Parkin R, Kishore U, Durham SR, Shamji MH. Surfactant Protein-D (SP-D): a
Potential Therapeutic Target for Seasonal Allergic Rhinitis. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND
IMMUNOLOGY Annual Meeting; 2017; J Allergy and Clinical Immunology 139(2):AB84.
23. Froese van Dijck A, Kousar L, Layhadi J, Fedina O, Calvosa S, Scadding GW, Durham SR, Shamji MH. SATB1 is
repressed in FoxP3+ Tregs following Grass Pollen Subcutaneous and Sublingual Immunotherapy and Correlates
with Clinical efficacy. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting;
2017; J Allergy and Clinical Immunology 139(2):AB192.
2016
24. Scadding G, Calderon M, Shamji M, Penagos M, Eifan A, Wurtzen PA, Sever M, Bahnson H, Lawson K, Harris K,
Qin T, Lim N, Plough A, Tchao N, Togias A, Durham SR. Grass pollen subcutaneous and sublingual immunotherapy
inhibit allergen-induced nasal and skin responses: a randomised controlled trial. BRITISH SOCIETY OF ALLERGY
AND CLINICAL IMMUNOLOGY Annual Meeting; 2016: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-
5774, NJ USA. Clinical and Experimental Allergy 46 (12), 1639-1640.
25. Singh I, Qaseem AS, Pathan AA., Durham SR, Kishore U, Shamji MH. Surfactant protein D (SP-D): a novel
therapeutic target for suppressing grass pollen-induced Th2 and B responses in seasonal allergic rhinitis. BRITISH
SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2016: WILEY-BLACKWELL 111 RIVER
ST, HOBOKEN 07030-5774, NJ USA. Clinical and Experimental Allergy 46, 1630.
26. Zadoyan G, Allekotte S, Shamji MH, Kasche EM, Singh J, Astvatsatourov A, Shah-Hosseini K, Pirotton S, Legon
T, Caplanusi A, Durham SR, Mosges R. Immunological biomarker predict clinical effects in subcutaneous peptide
allergen immunotherapy. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting;
2016: John Wiley & Sons, Inc. Allergy 71: 319-320.
27. Scadding G, Calderon M, Shamji MH, Penagos M, Eifan A, Phippard D, Harris KM, Chani E, Qin T, Tchao N, Togias
A, Sever ML, Lawson K, Wurtzen PA, Durham SR. Grass pollen subcutaneous and sublingual immunotherapy
inhibit allergen-induced nasal responses and local Th2 cytokines: a randomised controlled trial. EUROPEAN
ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2016: John Wiley & Sons, Inc. Allergy
71: 3-3.
28. Scadding G, Calderon M, Shamji MH, Penagos M, Eifan A, Phippard D, Harris KM, Tchao N, Lim N, Togias A,
Bahnson HT, Sever ML, Lawson K, Durham SR. Grass pollen subcutaneous immunotherapy results in faster and
greater suppression of allergen-induced skin responses compared to sublingual immunotherapy: a randomised
controlled trial. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2016: John
Wiley & Sons, Inc. Allergy 71: 172-172.
29. Kappen J, Schmidt-Weber C, Akdis M, Jensen-Jarolim E, Knol E, Klein-Tebbe J, Scadding G, Chaker A, Bohle B,
Valenta R, Poulsen L, Jacobsen L, Calderon M, Demoly P, Durham SR, Shamji MH. Evaluation of novel and current
biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic
asthma. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2016: John Wiley
& Sons, Inc. Allergy 71: 455-455.
30. Steveling-Klein EH, Lao-Araya M, Koulias C, Chowdhury M, Scadding G, Eifan A, Dumitru A, Penagos M, Calderon
M, Shamji M, Durham SR. A randomised placebo-controlled trial of sublingual immunotherapy tablet for seasonal
rhinitis to grass allergen: clinical outcomes, local symptoms and early time course of immunologic changes.
EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2016: John Wiley & Sons,
Inc. Allergy 71: 616-616.
31. Slovick AD, Douiri A, Muir R, Guerra A, Tsioulos K, Haye E, Lam E, Kelly J, Peacock J, Ying S, Shamji MH. A
Randomized Placebo-Controlled Trial of Intradermal Grass Pollen Immunotherapy for Seasonal Allergic Rhinitis.
AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2016; J Allergy and
Clinical Immunology 137(2): AB94.
32. Sharif HHA, Parkin R, Ito C, Scadding G, Durham SR, Shamji HM. Immune Tolerance Induction Following AIT Is
Associated with Induction of Circulating CD4+CXCR5+PD-1+FoxP3+ T Follicular Regulatory Cells. AMERICAN
ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2016; J Allergy and Clinical
Immunology 137(2): AB97.
33. Ntavli E, Turner PJ, Boyle RJ, Clark A, Robb AO, Durham SR, Shamji MH. Group 2 Innate Lymphoid Cells: New
Players in Peanut Allergy. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting;
2016; J Allergy and Clinical Immunology 137(2): AB74.
34. Steveling EH, Lao-Araya M, Koulias C, Chowdhury M, Scadding G, Eifan A, Dumitru A, Paniagua MJP, Shamji
MH, Durham SR. Randomised Placebo-Controlled Trial of Grass Pollen Allergen Tablet Immunotherapy for
Seasonal Rhinitis: Clinical and Surrogate Outcomes and Early Time Course of Immunologic Changes. AMERICAN
ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2016; J Allergy and Clinical
Immunology 137(2): AB197.
35. Mohseni YR, Turner PJ, Boyle RJ, Clark A, Robb AO, Durham SR, Shamji MH. Intracellular Expression of
Fluorochrome Labelled-Diamine Oxidase in Basophils: A Novel Diagnostic Tool for Peanut Allergy. AMERICAN
ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2016; J Allergy and Clinical
Immunology 137(2): AB137.
36. Allekotte S, Shamji MH, Zadoyan GV, Kasche EM, Shah-Hosseini K, Astvatsatourov A, Pirotton S, Caplanusi A,
Durham SR, Mosges R. Facilitated Allergen Binding (FAB) Is a Meaningful Immunological Biomarker for
Monitoring Immediate Clinical Efficacy in Short-Term Peptide Allergen Immunotherapy. AMERICAN ACADEMY
OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2016; J Allergy and Clinical Immunology 137(2):
AB403.
2015
37. 松岡伴和, 増山敬祐, Durham SR, Shamji MH. 抗原特異的 Th2 反応に対する IL-27 の免疫調節効果. 耳鼻咽喉科免
疫アレルギー. 2015;33(1):15-6.
38. Turner PJ, McMahon O, Switzer A, Clark A, Boyle RJ, Durham SR, Shamji MH. Marked Increase in Basophil
Activation during Non-Anaphylactic Allergic Reactions to Peanut in Man. AMERICAN ACADEMY OF ALLERGY,
ASTHMA AND IMMUNOLOGY Annual Meeting; 2015; J Allergy and Clinical Immunology 135(2):AB33.
39. Turner P, Mehr S, Sayers R, Wong M, Shamji M, Campbell D, Mills E, editors. Tolerance to boiled peanut in peanutallergic
children: are boiled peanuts an option for oral immunotherapy? BRITISH SOCIETY OF ALLERGY AND
CLINICAL IMMUNOLOGY Annual Meeting; 2015: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774,
NJ USA. Clinical and Experimental Allergy 45(2): 530.
40. Steveling E, Layhadi J, Scadding G, Calderon M, Durham S, Shamji M, editors. Diamine oxidase: a novel biomarker
for monitoring ex-vivo allergen-induced basophil reactivity following grass pollen immunotherapy. BRITISH
SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2015: WILEY-BLACKWELL 111 RIVER
ST, HOBOKEN 07030-5774, NJ USA. Clinical and Experimental Allergy 45(2): 539.
41. Shamji MH, Durham SR. Measuring histamine content and release at single-cell level during venom allergy
immunotherapy Reply. MOSBY-ELSEVIER 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA; 2015.
p. 1089-90.
42. Shamji MH, Ceuppens JL, Hellings PW, Durham S, Duchateau J, Parkin R, Legon T, Pirotton S, editors.
Immunogenicity Evaluation of Subcutaneous Administration of Peptide Hydrolysate from Lolium Perenne (gpASIT
plus (TM)) in Combination with Bacterial HSP70 (DnaK) in Patients with Seasonal Allergic Rhinitis: A Double Blind
Placebo Controlled Trial. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting;
2015; J Allergy and Clinical Immunology 135(2):AB159.
43. Shamji MH, Ceuppens JL, Hellings PW, Durham S, Duchateau J, Parkin R, Legon T, Pirotton S. Immunogenicity
Evaluation of Subcutaneous Administration of Peptide Hydrolysate from Lolium Perenne (gpASIT+ (TM)) in
Combination with Bacterial HSP70 (DnaK) in Patients with Seasonal Allergic Rhinitis: A Double Blind Placebo
Controlled Trial. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2015; J
Allergy and Clinical Immunology 135(2):AB159.
44. Scadding G, Eifan A, Penagos M, Dumitru A, Switzer A, McMahon O, Phippard D, Togias A, Durham S, Shamji M.
Local and systemic effects of cat allergen nasal provocation. BRITISH SOCIETY OF ALLERGY AND CLINICAL
IMMUNOLOGY Annual Meeting; 2015; Clinical and Experimental Allergy 45(2): 501.
45. Parkin R, Varricchi G, Steveling E, Marone G, Durham S, Shamji M, editors. Interleukin-21 induced IgE-synthesis
in memory B cells: a role for T follicular helper cells in seasonal allergic rhinitis. BRITISH SOCIETY OF ALLERGY
AND CLINICAL IMMUNOLOGY Annual Meeting; 2015: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-
5774, NJ USA. Clinical and Experimental Allergy 45(2): 539.
46. Lao-Araya M, Abubakar-Waziri H, Steveling E, Parkin R, Switzer A, Scadding G, Durham S, Shamji M, editors.
Grass pollen immunotherapy suppresses seasonal increases in type 2 innate lymphoid cells (ILC2s). BRITISH
SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2015: WILEY-BLACKWELL 111 RIVER
ST, HOBOKEN 07030-5774, NJ USA. Clinical and Experimental Allergy 45(2): 538-39.
47. Abubakar-Waziri H, Parkin R, Switzer A, Steveling E, Scadding G, Durham S, Shamji M, editors. Local nasal
protective IgG4 antibodies: novel biomarker for monitoring allergen immunotherapy. BRITISH SOCIETY OF
ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2015: WILEY-BLACKWELL 111 RIVER ST,
HOBOKEN 07030-5774, NJ USA. Clinical and Experimental Allergy 45(2): 539-40.
2014
48. Zhang J, Steveling E, Yan R, Eifan A, Parkin R, Scadding GW, Shamji MH, Durham SR. Local’Protective’IgG4
Antibodies In Nasal Fluid Are Elevated Following Grass Pollen Immunotherapy. AMERICAN ACADEMY OF
ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2014; J Allergy and Clinical Immunology 133(2):AB157.
49. Zadoyan G, Hauswald B, Yarin Y, Shah-Hosseini K, Shamji M, Durham S, Pirotton S, Moesges R, Legon T, editors.
Safety, clinical tolerability and immunogenicity of increasing doses of gpASIT plus (TM) administered
subcutaneously to hay fever patients-a phase IIa dose-escalation study. EUROPEAN ACADEMY OF ALLERGY
AND CLINICAL IMMUNOLOGY Annual Meeting; 2014: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-
5774, NJ USA. Allergy 69: 154.
50. Turner P, Mehr S, Sayers R, Wong M, Shamji M, Campbell D, Mills E, editors. Tolerance to boiled peanut in peanutallergic
children: potential for oral immunotherapy? EUROPEAN ACADEMY OF ALLERGY AND CLINICAL
IMMUNOLOGY Annual Meeting; 2014: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
Allergy 69: 382.
51. Shamji MH. Mechanisms of Allergen-Specific Sublingual Immunotherapy and the Use of Biological Markers in
Allergic Rhinitis. Current Treatment Options in Allergy. 2014;1(1):1-13.
52. Shamji M, Ceuppens J, Hellings P, Durham S, Duchateau J, Legon T, Pirotton S, editors. Immunogenicity
evaluation of subcutaneous administration of peptide hydrolysate from Lolium perenne (gpASIT plus TM) in
combination with bacterial HSP70 (DnaK) in patients with seasonal allergic rhinitis. EUROPEAN ACADEMY OF
ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2014: John Wiley & Sons, Inc. Allergy 69: 31.
53. Shamji MH, Layhadi J, Perera-web A, Yan R, Durham SR. IL-35-Producing T Cells (iTR35) Inhibit Th2 Effector
Function, Induce Infectious Tolerance and Are Elevated Following Grass Pollen Sublingual Immunotherapy.
AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2014. J Allergy and Clinical
Immunology 133(2):AB51
54. Scadding GW, Eifan A, Lao-Araya M, Paniagua MJP, Poon SY, Steveling E, Goldstone A, Yan R, Switzer A,
Phippard D, Shamji MH, Durham SR. Grass Pollen Immunotherapy: Impaired Allergen-Induced Nasal and
Cutaneous Responses Correlate With Overall Seasonal Symptom Scores and Are Associated With Suppressed
Local Th2 Cytokines In Nasal Fluid. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual
Meeting; 2014; J Allergy and Clinical Immunology 133(2):AB158.
55. Mehr S, Turner PJ, Campbell DE, Sayers R, Shamji MH, Mills E, Wong M, editors. TOLERANCE TO BOILED
PEANUT IN PEANUT-ALLERGIC CHILDREN. INTERNAL MEDICINE JOURNAL; 2014: WILEY-BLACKWELL 111
RIVER ST, HOBOKEN 07030-5774, NJ USA. 44: 17.
56. Matsuoka T, Yan R, Scadding GW, Durham SR, Shamji MH. Interleukin IL-27+ Dendritic Cells Modulate Ex-Vivo
Th2 Responses In a Pdl-1-Dependent Manner and Increase In-Vivo Following Grass Pollen Immunotherapy.
AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2014; J Allergy and Clinical
Immunology 133(2):AB157.
57. Gadermaier E, James LK, Shamji MH, Blatt K, Garmatiuk T, Beavil R, Flicker S, Valent P, Durham SR, Gould HJ.
A Phl p 7-specific IgG4 antibody inhibits allergic patients IgE cross-reactivity to allergens from the EF-hand family:
importance of affinity and degree of cross-reactivity. Clinical and Translational Allergy. 2014;4(2):1-2.
58. Couto-Francisco NC, Matsuoka T, Yan R, Durham SR, Shamji MH. Interleukin 35 Modulates TSLP, IL-25 and IL-
33 Primed Dendritic Cells and Inhibits Naive T Cell Differentiation and Grass Pollen-Specific T Cell Proliferation.
AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; J Allergy and Clinical
Immunology 2014; 133(2):AB149.
59. Charlesworth JE, Scadding GW, Eifan A, Yan R, Goldstone A, Calderon MA, Durham SR, Shamji MH. IL-10-
Producing B Cells Are Increased After Grass Pollen Immunotherapy Compared To Untreated Grass Pollen Allergic
Controls: A Blinded Cross-Sectional Study. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY
Annual Meeting; 2014; J Allergy and Clinical Immunology 133(2):AB53.
2013
60. Shamji M, Saleem N, Nicholson J, Schmidt-Weber C, Chaker A, Durham S, editors. Local nasal antiinflammatory
IgG4 responses are induced following grass pollen sublingual and subcutaneous immunotherapy. EUROPEAN
ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2013: WILEY-BLACKWELL 111 RIVER
ST, HOBOKEN 07030-5774, NJ USA. Allergy 68: 21-22.
61. Shamji M, Matsuoka T, Durham S, editors. IL-27 supresses allergen-driven TH2 responses and IL-27+ dendritic
cells are significantly reduced in grass pollen allergic individuals compared to non-atopic controls. EUROPEAN
ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2013: WILEY-BLACKWELL 111 RIVER
ST, HOBOKEN 07030-5774, NJ USA. Allergy 68: 23.
62. Shamji M, Layhadi J, Scadding G, Durham S, editors. A novel subset of regulatory T cells: interleukin-35 producing
T regs (iTR35) are induced after grass pollen sublingual immunotherapy. EUROPEAN ACADEMY OF ALLERGY
AND CLINICAL IMMUNOLOGY Annual Meeting; 2013: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-
5774, NJ USA. Allergy 68: 67.
63. Shamji M, Layhadi J, Perera-Web A, Scadding G, Durham SR. IL-35+ Regulatory T Cells Suppress Grass Pollen-
Driven Th2 Responses and Are Induced Following Grass Pollen-Specific Sublingual Immunotherapy. AMERICAN
ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2013; J Allergy and Clinical Immunology
131(2):AB146.
64. Scadding G, Eifan A, Penagos M, Koed GK, Wurtzen PA, Shamji M, Durham S. Grass pollen nasal challenge is
associated with increases in Th2 cytokines, Eotaxin, MDC and IL-6 in nasal fluid. BRITISH SOCIETY OF ALLERGY
AND CLINICAL IMMUNOLOGY Annual Meeting; 2013; Clinical and Experimental Allergy 3(2): P29
65. Saleem N, Chaker A, Zissler U, Schmidt-Weber CB, Durham SR, Shamji MH. Local
Nasal’Protective’Immunoglobulin G4 (IgG4) Responses in Nasal Fluid Following Grass Pollen Sublingual
Immunotherapy. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2013; J
Allergy and Clinical Immunology 131(2):AB202.
66. Qaseem A, Pathan A, Layhadi J, Chinea Y, Durham S, Kishore U, Shamji M. Recombinant human pulmonary
surfactant protein-D (rhSP-D) modulates Th2 responses and suppresses IgE-facilitated allergen binding to B cells.
European Respiratory Journal. 2013; 42 (Suppl 57):P898.
67. Pillai PC, Fang C, Chan Y-C, Shamji MH, Harper C, Ohm-Laursen L, Durham SR, Menzies-Gow A, Rajakulasingam
R, Sun Y. Detection and Quantitation of Total and Allergen-Specific IgE in the Bronchial Mucosa of Atopic and Non-
Atopic Asthmatics. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2013;
J Allergy and Clinical Immunology 131(2):AB331.
68. Matsuoka T, Stott B, Durham SR, Shamji MH. Immunomodulatory Effects of IL-27 on Allergen-induced Th2
responses. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2013; J Allergy
and Clinical Immunology 131(2):AB203.
69. Matsuoka T, Shamji MH, Durham SR. Review Series: Immunotherapy and Tolerance—Cutting Edge. Allergology
International. 2013;62: 403-13.
70. Matsuoka T, Durham S, Shamji M. Interleukin 27-primed dendritic cells suppress grass pollen-specific Th2
responses in patients with seasonal allergic rhinitis. BRITISH SOCIETY OF ALLERGY AND CLINICAL
IMMUNOLOGY Annual Meeting; 2013: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
71. Marri E, Nayak A, Qaseem A, Pednekar L, Shamji M, Mitchell D, Kishore U, editors. Modulation of DC-SIGNallergen
interaction by surfactant protein SP-D. BRITISH SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY
Annual Meeting; 2013: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
72. Cifuentes L, Ploetz S, Chaker A, Pennino D, Durham S, Shamji M, Ollert M, Ring J, Schmidt-Weber C, Darsow U,
editors. In vitro immunomonitoring of birch pollen-allergic patients during allergen-specific immunotherapy.
EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2013: WILEYBLACKWELL
111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
73. Charlesworth JE, Goldstone A, Calderon MA, Cousins D, Durham SR, Shamji MH. Grass Pollen Allergics Have
Fewer IL-10-Producing B Cells Than Non-Atopic Controls. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND
IMMUNOLOGY Annual Meeting; 2013;2(131):AB204.
74. Charlesworth J, Goldstone A, Yan R, Calderon M, Cousins D, Durham S, Shamji M, editors. Regulatory B cells are
reduced amongst grass-pollen allergic patients compared with non-allergic controls. BRITISH SOCIETY OF
ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2013: WILEY-BLACKWELL 111 RIVER ST,
HOBOKEN 07030-5774, NJ USA.
2012
75. Shamji M, Patel V, Till S, Phippard D, Turcanu V, Durham S, editors. Functional but not quantitative peanut-specific
IgE antibodies as diagnostic biomarker for peanut allergy. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL
IMMUNOLOGY Annual Meeting; 2012: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
76. Shamji M, Layhadi J, Cheung D, Khan S, Phippard D, Durham S. 97 Grass Pollen Allergen-induced Surface
Expression of CD203C, CD63 and CD107A on CRTH2+ Basophils: Novel Biomarkers for Monitoring Efficacy of
Allergen-specific Immunotherapy. The World Allergy Organization Journal. 2012;5(Suppl 2):S49-S.
77. Shamji M, Kent A, Baron-Bodo V, Rodriguez P, Robert Z, Moingeon P, Durham S, editors. Pre-coseasonal
treatment with five-grass sublingual tablets induces inhibitory antibodies that correlate with clinical efficacy.
EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2012: WILEYBLACKWELL
111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
78. Shamji M, Bellido V, Scadding G, Leyhadi J, Calderon M, Togias A, Tchao N, Plaut M, Turka L, Phippard D. Effects
of Nasal Allergen Challenge on T cell signature in Peripheral Blood in Patients with Severe Seasonal Allergic
Rhinitis. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting;
2012;129(2):AB196.
79. Shamji M, Achkova D, Layhadi J, Perera-Webb A, Scadding G, Khan S, Durham S, editors. IL-35 producing
regulatory T cells modulate grass pollen-specific Th2 responses and are induced following sublingual grass pollen
immunotherapy. BRITISH SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2012: WILEYBLACKWELL
111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
80. Shamji M, Achkova D, Chung W, Janice L, Scadding G, Phippard D, Durham S, editors. Inducible IL-35+ T regs
attenuate allergen-specific Th2 and Th17 responses in patients with seasonal allergic rhinitis. EUROPEAN
ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2012: WILEY-BLACKWELL 111 RIVER
ST, HOBOKEN 07030-5774, NJ USA.
81. Rotiroti G, Shamji M, Durham SR, Till SJ. Repeated low-dose intradermal allergen injection suppresses allergeninduced
cutaneous late responses. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual
Meeting; 2012;130(4):918-24. e1.
82. Qaseem A, Pathan A, Layhadi J, Chianea Y, Durham S, Kishore U, Shamji M, editors. Recombinant human
pulmonary surfactant protein-D (rhSP-D) suppresses IgE-facilitated allergen binding to B cells. BRITISH SOCIETY
OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2012: WILEY-BLACKWELL 111 RIVER ST,
HOBOKEN 07030-5774, NJ USA.
83. Charlesworth J, Khan S, Scadding G, Cousins D, Durham S, Shamji M, editors. IL-10-producing regulatory B cells
suppress allergen-specific T cell proliferation and are elevated ex vivo following specific immunotherapy. BRITISH
SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2012: WILEY-BLACKWELL 111 RIVER
ST, HOBOKEN 07030-5774, NJ USA.
84. Achkova D, Chung F, Layhadi J, Scadding G, Charlesworth J, Phippard D, Durham S, Shamji M. Interleukin-35
Suppresses Allergen-specific Th2 Response in Patients with Grass pollen induced Seasonal Allergic Rhinitis.
AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2012;129(2):AB208.
2011
85. Varga E, Kausar F, Sturm G, Aberer W, Zach M, Durham S, Shamji M, editors. Repeated exposure to bee venom
during the beekeeping season induces high levels of venom-specific IgG4 serum antibodies with serum inhibitory
activity for IgE-facilitated antigen binding in non-allergic beekeepers. EUROPEAN ACADEMY OF ALLERGY AND
CLINICAL IMMUNOLOGY Annual Meeting; 2011: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774,
NJ USA.
86. Shamji M, Layhadi J, Cheung D, Khan S, Durham S, editors. Allergen-induced expression of CD203c, CD63 and
CD107a on CRTH2+ basophils: Biomarkers for monitoring efficacy of grass pollen immunotherapy. BRITISH
SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2011: WILEY-BLACKWELL
COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA.
87. Shamji M, Hamilton A, Harris J, Jeal H, Cullinan P, Durham S, Jones M, editors. Is’ natural tolerance’at high allergen
exposure associated with inhibitory IgG4 antibodies? BRITISH SOCIETY OF ALLERGY AND CLINICAL
IMMUNOLOGY Annual Meeting; 2011: WILEY-BLACKWELL COMMERCE PLACE, 350 MAIN ST, MALDEN
02148, MA USA.
88. Shamji M, Chaker A, Cheung D, Poon M, Schmidt-Weber C, Durham S. Frequency Of Grass Pollen-specific Il-4,
Il-10 And Dual Il-4 And Il10 Positive Cells In Atopic And Non-atopic Individuals In And Out Of The Pollen Season
AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2011;127(2):AB128.
89. Patel R, Shamji M, Flohr C, Brown A, Pritchard D, Till S, editors. Necatoramericanus (hookworm) excretorysecretory
product modulates in vitro recall responses to grass pollen in allergic subjects. BRITISH SOCIETY OF
ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2011: WILEY-BLACKWELL COMMERCE PLACE, 350
MAIN ST, MALDEN 02148, MA USA.
90. Nicholson J, Ratnayake A, Poon M, Togias A, Durham S, Shamji M. Ige-facilitated Binding Of Cockroach Allergenige
Complexes To B Cells: An Assay To Monitor Efficacy During Immunotherapy? AMERICAN ACADEMY OF
ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2011;127(2):AB225.
91. Dumitru F, Schmidt-Weber C, Shamji M, Durham S, Hindersin S, Scheckenbach K, Wagenmann M, Klenzner T,
Greve J, Zimmermann C, editors. Petasites hybridus extract (Ze 339) as an alternative, innovative treatment of
seasonal allergic rhinitis. EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting;
2011: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
92. Dumitru AF, Shamji M, Wagenmann M, Hindersin S, Scheckenbach K, Greve J, Klenzner T, Hess L, Nebel S,
Zimmermann C. Petasol butenoate complex (Ze 339) relieves allergic rhinitis–induced nasal obstruction more
effectively than desloratadine. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual
Meeting; 2011; 127(6):1515-21. e6.
2010
93. Shamji MH. Grass pollen immunotherapy: Immunoreactive and functional antibody responses and their relationship
to clinical response: Imperial College London; 2010.
94. Shamji M, Ljørring C, Francis J, Kimber I, Frew A, Lund K, Würtzen P, Durham S. Blocking antibodies: relationship
between IgG4-associated inhibitory activity and clinical response to grass-pollen immunotherapy. AMERICAN
ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2010;125(2):AB131.
2009
95. Shamji M, Ljorring C, Francis J, Kimber I, Frew A, Lund K, Wurtzen P, Durham S, editors. Functional antibodies: a
time-dependent and dose-related response following grass pollen immunotherapy. BRITISH SOCIETY OF
ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2009: WILEY-BLACKWELL PUBLISHING, INC
COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA.
96. Shamji M, James L, Francis J, Kimber I, Till S, Durham S, editors. Long-term remission after withdrawal of
subcutaneous immunotherapy is associated with persistent elevated serum IgG4-dependent inhibitory activity that
is not detectable by measuring serum immunoreactive allergen-specific IgG4 antibody levels. EUROPEAN
ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2009: WILEY-BLACKWELL
PUBLISHING, INC COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA.
97. Scadding G, Shamji M, Jacobson M, Schmidt-Weber C, Nouri-Aria K, Durham S, editors. Foxp3 is increased in the
sublingual mucosa after grass pollen sublingual immunotherapy and is accompanied by increases in serum IgG4
and serum inhibitory activity for allergen-IgE binding to B cells. EUROPEAN ACADEMY OF ALLERGY AND
CLINICAL IMMUNOLOGY Annual Meeting; 2009: WILEY-BLACKWELL PUBLISHING, INC COMMERCE PLACE,
350 MAIN ST, MALDEN 02148, MA USA.
98. Scadding G, Shamji M, Jacobson M, Lee D, Kimber I, Schmidt-Weber C, Nouri-Aria K, Durham S, editors. Local
mucosal and systemic regulatory effects of grass pollen sublingual immunotherapy. BRITISH SOCIETY OF
ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2009: WILEY-BLACKWELL PUBLISHING, INC
COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA.
99. Ljørring C, Shamji M, Würtzen P, Lund K, Frew A, Durham S, Ipsen H. IgE-blocking Antibodies may account for a
large Proportion of the observed Treatment Effect Induced by Specific Immunotherapy (SIT). AMERICAN
ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2009; 123(2):S154.
2008
100. Shamji M, Barkans J, Francis J, Kimber I, Durham S. Confocal Imaging of Low Affinity IgE Receptor Distribution
on B cells: Effects of Grass Pollen Immunotherapy. AMERICAN ACADEMY OF ALLERGY, ASTHMA AND
IMMUNOLOGY Annual Meeting; 2008; 121(2):S141.
2007
101. Shamji MH, Barkans J, Kimber I, Francis JN, Durham SR, editors. Visualising the inhibitory effect of blocking
antibodies in grass pollen immunotherapy using confocal microscopy. BRITISH SOCIETY OF ALLERGY AND
CLINICAL IMMUNOLOGY Annual Meeting; 2007: BLACKWELL PUBLISHING 9600 GARSINGTON RD, OXFORD
OX4 2DQ, OXON, ENGLAND.
2006
102. Shamji M, Wilcock L, Larche M, Francis J, Durham S. Validation of a functional assay of IgE-facilitated CD23-
dependent allergen binding to B cells to monitor clinical efficacy of immunotherapy. AMERICAN ACADEMY OF
ALLERGY, ASTHMA AND IMMUNOLOGY Annual Meeting; 2006; 117(2):S330.
103. Steel A, Cox A, Shamji M, Henderson D, Gotch F, Gazzard B, Kelleher P, editors. CD38 expression on CD8+
T cells is a marker of residual viral replication in HIV-1 infected patients on successful anti-retroviral therapy.
BRITISH SOCIETY OF IMMUNOLOGY; 2005: BLACKWELL PUBLISHING 9600 GARSINGTON RD, OXFORD
OX4 2DQ, OXON, ENGLAND.
104. Shamji M, Wilcock L, Larche M, Durham S, Francis J, editors. Analytical validation of a novel flow cytometricbased
Facilitated Allergen Presentation (FAP) assay as a tool for monitoring allergen-specific immunotherapy.
BRITISH SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 2005: BLACKWELL
PUBLISHING 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND.
105. Shamji M. Mechanisms and Biomarkers Related to Sublingual and Subcutaneous Immunotherapy. BRITISH
SOCIETY OF ALLERGY AND CLINICAL IMMUNOLOGY Annual Meeting; 1998; 102:558-62.
106. Shamji M, Henderson D. 52P Medical Research Society.
107. Prathap Chellappan Pillai M, Fang C, Shamji MH, Ohm-Laursen L, Menzies-Gow A, Rajakulasingam R, Sun
Y. L14 Antibiotic Exposure and the Risk of Food Allergy in Young Children Bryan L. Love, PharmD, BCPS1, Joshua
Mann, MD, MPH2, James W. Hardin, PhD3, David Amrol, MD2; 1South Carolina College of Pharmacy, Columbia,
SC, 2University of South Carolina School of Medicine, Colum. J BRITISH SOCIETY OF ALLERGY AND CLINICAL
IMMUNOLOGY Annual Meeting; 2006; 131(2).
Мешкова Раиса Яковлевна, окончила Смоленский государственный медицинский институт (СГМИ) в 1973 году, а затем клиническую ординатуру по детской инфекции. После поступила и закончила аспирантуру по иммунологии. В 1984 году защитила кандидатскую диссертацию «РТПХ в условиях репаративной регенерации селезенки». С 1988 года возглавляет кафедру клинической иммунологии и аллергологии СГМИ. В 1996 году защитила докторскую диссертацию на тему «Скрининг больных с нарушениями иммунной системы и оказание специализированной лечебно-диагностической помощи» и была избрана на должность проффесора кафедры клинической иммунологии и аллергологии Смоленской государственной медицинской академии.
Председатель редакционного совета
PERSONAL INFORMATION
Prosekova Elena Viktorovna in 1983 graduated summa cum laude from the Vladivostok State Medical Institute with a degree in general medicine and started internship as a pediatrician with a subsequent primary specialization in clinical immunology and allergology.
Fedoskova T.G. is the graduate of the 2nd Moscow State Medical Institute named after N.I. Pirogov. She worked at the Scientific Advisory Department of the Institute of Immunology as a leading researcher between 1996 and 2016, and since 2016 leads the Laboratory of Molecular Allergy Mechanisms.
Kofiadi I.A. is a specialist in the field of genetics of immune response, cell physiology, molecular immunology, as well as the author of more than 60 scientific papers, 2 monographs, 2 patents for inventions and utility models.
Лусс Людмила Васильевна, 06 июня 1941 г.р.
Beltyukov Evgeny Kronidovich graduated from Sverdlovsk State Medical Institute in 1977, completed internship in therapy at the Sverdlovsk Regional Clinical Hospital No. 1 (SOKB No. 1) in 1978. He specialized in clinical allergology at the Central Order of Lenin Institute for Advanced Medical Studies in 1978, then worked as an allergist at the allergology department of the Clinical Hospital No. 1, and the head of the pulmonology department of the City Clinical Hospital No. 6 in Ekaterinburg. He passed his PhD defense on bronchial asthma in 1994. He headed the Department of Allergology and Immunology GBUZ SO SOKB №1 from 2001 to 2006. He defended his doctoral thesis “Medical and economic effectiveness of modern technologies for the diagnosis and treatment of bronchial asthma at the regional and local level” at the National Research Center “Institute of Immunology” Federal Medical Biological Agency in Moscow, Russia, in 2004.
Tamarakhon Aripova, in 1976 she graduated with honors from the medical faculty of the Tashkent State Medical Institute. In 1979, in Moscow, she successfully defended her PhD dissertation on “The effect of methylcholanthrene and carcinogenesis induced by him on the individual stages of immunogenesis”, and in 1992, she successfully defended her doctoral dissertation in Moscow on the subject: “Cellular mechanisms and correction of immunodeficiency in cell growth”. In 2007, she was awarded the academic title of professor and in 2017 received the title of academician of the Academy of Sciences of the Republic of Uzbekistan. From 2003 to the present, he heads the Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan.
Ирина Николаевна Захарова – доктор медицинских наук, профессор, заслуженный врач России, заведующая кафедрой педиатрии с курсом поликлинической педиатрии ФГБОУ ДПО Российская медицинская академия непрерывного профессионального образования Минздрава России, Почетный профессор Научного центра здоровья детей МЗ РФ.
Окончила с отличием первый лечебный факультет Ташкенского государственного медицинского института (1990) клиническую ординатуру (1993) и аспирантуру (1996) по специальностям иммунология и аллерглогия/ терапия, тренинг в Тель-Авивском медицинском университете, Израиль (1996), занималась начной работой в университете Виттен/Хердеке, Германия (2000-2003), получила признание диплома PhD в Германии в 2002 году. Виктория Гариб имеет звание профессора в области иммунологии и аллергологии с 2005 года. Она заведовала Центральной научно-исследовательской лабораторией, с 2005 года – кафедрой медицинской иммунологии с Центром молекулярной медицины. Одновременно с этим, с 2006 по 2013 годы проф. Гариб Виктория работала на должности проректора по международным связям Ташкентского института усовершенствования врачей, была экспертом и ученым секретарем медико-биологической секции ВАК. С 2014 года по настоящее время работает в департаменте патофизиологии и исследований аллергии Венского медицинского университета, Австрия. С 2018 года также является международным консультантом Министерства инновационного развития Республики Узбекистан. C 2013 года является организатором и Вице-Президентом Международной платформы университетов по молекулярной аллергологии и иммунологии INUNIMAI, Вена, Австрия. В 2018 году по ее инициативе и консультациях при министерстве инновационного развития Республики Узбекистан был создан первый в мире Международный Центр Молекулярной Аллергологии.
